Chemical motifs that redox cycle and their associated toxicity (Q58293268)

1

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Russell Naven

2

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Arjun Narayanan

3

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Yvonne Will

4

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Lyn H. Jones

Structural alert/reactive metabolite concept as applied in medicinal chemistry to mitigate the risk of idiosyncratic drug toxicity: a perspective based on the critical examination of trends in the top 200 drugs marketed in the United States

5

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publication date

2013

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published in

MedChemComm

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volume

4

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issue

8

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page(s)

1175

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cites work

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Production of hydrogen peroxide and redox cycling can explain how sanguinarine and chelerythrine induce rapid apoptosis

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Profiling the NIH Small Molecule Repository for compounds that generate H2O2 by redox cycling in reducing environments

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Redox cycling compounds generate H2O2 in HTS buffers containing strong reducing reagents--real hits or promiscuous artifacts?

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A simple colorimetric method for the measurement of hydrogen peroxide produced by cells in culture

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Phototoxicity and photogenotoxicity of nine pyridone derivatives

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Photoinduced redox cycle of riboflavin at a water/oil interface

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Reduction and uptake of methylene blue by human erythrocytes

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Aminothienopyridazines and methylene blue affect Tau fibrillization via cysteine oxidation

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The bacterial redox signaller pyocyanin as an antiplasmodial agent: comparisons with its thioanalog methylene blue

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Cell death from antibiotics without the involvement of reactive oxygen species

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