Dynamics of Intact Immunoglobulin G Explored by Drift-Tube Ion-Mobility Mass Spectrometry and Molecular Modeling (Q58166059)

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20 March 2020

title

Dynamics of intact immunoglobulin G explored by drift-tube ion-mobility mass spectrometry and molecular modeling (English)

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7

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author name string

Massimiliano Porrini

2

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20 March 2020

Kamila J Pacholarz

1

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20 March 2020

Rachel A Garlish

3

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Rebecca J Burnley

4

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Richard J Taylor

5

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Alistair J Henry

6

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language of work or name

English

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publication date

10 June 2014

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Angewandte Chemie International Edition

20 March 2020

number of pages

5

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based on heuristic

inferred from page(s)

published in

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volume

53

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issue

30

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page(s)

7765-7769

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Strategies and challenges for the next generation of therapeutic antibodies

20 March 2020

cites work

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Characterization of therapeutic antibodies and related products.

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The impact of mass spectrometry on the study of intact antibodies: from post-translational modifications to structural analysis.

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Resolving disulfide structural isoforms of IgG2 monoclonal antibodies by ion mobility mass spectrometry

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Complementary MS methods assist conformational characterization of antibodies with altered S-S bonding networks

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The role of ion mobility spectrometry-mass spectrometry in the analysis of protein reference standards.

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Time resolved native ion-mobility mass spectrometry to monitor dynamics of IgG4 Fab arm exchange and "bispecific" monoclonal antibody formation

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Development of an ion mobility quadrupole time of flight mass spectrometer

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The structural requirements for complement activation by IgG: does it hinge on the hinge?

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Structural and functional characterization of disulfide isoforms of the human IgG2 subclass

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Human IgG4 binds to IgG4 and conformationally altered IgG1 via Fc-Fc interactions.

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Species-Specific Determinants in the IgG CH3 Domain Enable Fab-Arm Exchange by Affecting the Noncovalent CH3-CH3 Interaction Strength

21 January 2018

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Freezing immunoglobulins to see them move

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Crystal structure of a neutralizing human IGG against HIV-1: a template for vaccine design

21 January 2018

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Crystallographic structure of an intact IgG1 monoclonal antibody

21 January 2018

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Refined structure of an intact IgG2a monoclonal antibody

21 January 2018

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Solvent content of protein crystals

21 January 2018

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Matthews coefficient probabilities: Improved estimates for unit cell contents of proteins, DNA, and protein-nucleic acid complex crystals

21 January 2018

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Correlation between segmental flexibility and effector function of antibodies

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/ANIE.201402863

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20 March 2020

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