Purinogenic lymphocytotoxicity: Clues to a wider chemotherapeutic potential for the adenosine deaminase inhibitors (Q58025114)

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15 October 2019

title

Purinogenic lymphocytotoxicity: clues to a wider chemotherapeutic potential for the adenosine deaminase inhibitors (English)

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15 October 2019

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15 October 2019

author name string

R M Fox

series ordinal

2

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15 October 2019

publication date

1 January 1983

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Cancer Chemotherapy and Pharmacology

15 October 2019

published in

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15 October 2019

volume

10

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15 October 2019

issue

2

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15 October 2019

page(s)

73-78

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https://scigraph.springernature.com/pub.10.1007/bf00446213

15 October 2019

exact match

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cites work

Purinogenic Immunodeficiency Diseases: Clinical Features and Molecular Mechanisms

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Crossref

https://api.crossref.org/works/10.1007%2FBF00446213

Possible metabolic basis for the different immunodeficient states associated with genetic deficiencies of adenosine deaminase and purine nucleoside phosphorylase

21 January 2018

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12 December 2020

Purine nucleoside phosphorylase deficiency: a molecular model for selective loss of T cell function

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12 December 2020

In vitro and in vivo effect of deoxycoformycin in human T cell leukemia

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12 December 2020

Phase I study of 2'-deoxycoformycin in acute lymphoblastic leukemia

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Mechanism of deoxyadenosine-induced catabolism of adenine ribonucleotides in adenosine deaminase-inhibited human T lymphoblastoid cells

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12 December 2020

Effects of mutational loss of adenosine kinase and deoxycytidine kinase on deoxyATP accumulation and deoxyadenosine toxicity in cultured CEM human T-lymphoblastoid cells

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12 December 2020

Treatment of acute lymphoblastic leukemia with 2'-deoxycoformycin: clinical and biochemical consequences of adenosine deaminase inhibition

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12 December 2020

Selective toxicity of purine deoxynucleosides for human lymphocyte growth and function

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12 December 2020

Identification and quantitation of adenine deoxynucleotides in erythrocytes of a patient with adenosine deaminase deficiency and severe combined immunodeficiency

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12 December 2020

Lymphospecific toxicity in adenosine deaminase deficiency and purine nucleoside phosphorylase deficiency: Possible role of nucleoside kinase(s)

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12 December 2020

An in vivo and in vitro evaluation of 1-beta-D-ribofuranosyl-1,2,4-triazole-3-carboxamidine: an inhibitor of human lymphoblast purine nucleoside phosphorylase

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12 December 2020

Adenosine deaminase inhibition for immunosuppression

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12 December 2020

Specific immunosuppressive effects of constant infusion of 2'-deoxycoformycin

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12 December 2020

Differences in deoxyadenosine metabolism in human and mouse lymphocytes

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12 December 2020

The effect of nucleosides and deoxycoformycin on adenosine and deoxyadenosine inhibition of human lymphocyte activation

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12 December 2020

Apparent suicide inactivation of human lymphoblast S-adenosylhomocysteine hydrolase by 2'-deoxyadenosine and adenine arabinoside. A basis for direct toxic effects of analogs of adenosine

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12 December 2020

ATP depletion as a consequence of adenosine deaminase inhibition in man.

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12 December 2020

Deoxyadenosine triphosphate as a potentially toxic metabolite in adenosine deaminase deficiency

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12 December 2020

Therapeutic selectivity of and predication of response to 2'-deoxycoformycin in acute leukaemia

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The biochemical and clinical consequences of 2'-deoxycoformycin in refractory lymphoproliferative malignancy.

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12 December 2020

In vivo inactivation of erythrocyte S-adenosylhomocysteine hydrolase by 2'-deoxyadenosine in adenosine deaminase-deficient patients

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12 December 2020

Effect of 2'-deoxycoformycin on erythroid, granulocytic, and T-lymphocyte colony growth

1 reference

12 December 2020

Deoxyguanosine Triphosphate as a Possible Toxic Metabolite in the Immunodeficiency Associated with Purine Nucleoside Phosphorylase Deficiency

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12 December 2020

Thymus cell migration. Quantitative aspects of cellular traffic from the thymus to the periphery in mice

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12 December 2020

Effects of 2'-deoxycoformycin on the metabolism of purines and the survival of malignant cells in a patient with T-cell leukemia

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12 December 2020

S-adenosylhomocysteine hydrolase inhibition in deoxyadenosine-treated human T-lymphoblasts and resting peripheral blood lymphocytes

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12 December 2020

Biochemical basis for the enhanced toxicity of deoxyribonucleosides toward malignant human T cell lines

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12 December 2020

Inhibition of adenosine deaminase activity results in cytotoxicity to T lymphoblasts in vivo

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12 December 2020

Purine deoxynucleoside toxicity in nondividing human lymphoid cells

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12 December 2020

Nucleoside-phosphorylase deficiency in a child with severely defective T-cell immunity and normal B-cell immunity

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12 December 2020

Ecto-adenosine triphosphatase deficiency in cultured human T and null leukemic lymphocytes. A biochemical basis for thymidine sensitivity

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12 December 2020

Inhibition for Immunosuppression

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12 December 2020

A role for purine metabolism in the immune response: Adenosine-deaminase activity and deoxyadenosine catabolism

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12 December 2020

Deoxycoformycin-induced response in chronic lymphocytic leukaemia: deoxyadenosine toxicity in non-replicating lymphocytes

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12 December 2020

Adenosine-deaminase deficiency in two patients with severely impaired cellular immunity

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12 December 2020

G1-phase arrest of cultured human leukemic T-cells induced by deoxyadenosine.

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12 December 2020

The clinical pharmacology of the adenosine deaminase inhibitor 2'-deoxycoformycin

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12 December 2020

Remission induction with adenosine-deaminase inhibitor 2'-deoxycoformycin in Thy-lymphoblastic leukaemia

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12 December 2020

Differential sensitivity of human leukemic T cell lines and B cell lines to growth inhibition by deoxyadenosine

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12 December 2020

The potential importance of soluble deoxynucleotidase activity in mediating deoxyadenosine toxicity in human lymphoblasts

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12 December 2020

Inhibition of purine nucleoside phosphorylase by 8-aminoguanosine: selective toxicity for T lymphoblasts

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12 December 2020

Nucleotide-metabolizing enzymes and lymphocyte differentiation

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12 December 2020

Purinogenic immunodeficiency diseases: selective toxicity of deoxyribonucleosides for T cells

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12 December 2020

Identifiers

DOI

10.1007/BF00446213

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:6600985%20AND%20SRC:MED&resulttype=core&format=json

15 October 2019

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