Requirement for a Negative Charge at Threonine 60 of the FcRγ for Complete Activation of Syk (Q57997612)

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11 December 2019

title

Requirement for a negative charge at threonine 60 of the FcRgamma for complete activation of Syk (English)

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11 December 2019

4

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author name string

P G Swann

1

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11 December 2019

S Odom

2

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11 December 2019

Y J Zhou

3

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11 December 2019

P M Blumberg

5

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11 December 2019

P Draber

6

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11 December 2019

J Rivera

7

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11 December 2019

language of work or name

English

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publication date

1 August 1999

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Journal of Biological Chemistry

11 December 2019

published in

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volume

274

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11 December 2019

issue

33

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page(s)

23068-23077

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Abolition of anaphylaxis by targeted disruption of the high affinity immunoglobulin E receptor alpha chain gene

11 December 2019

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Nasal mast cells in perennial allergic rhinitics exhibit increased expression of the Fc epsilonRI, CD40L, IL-4, and IL-13, and can induce IgE synthesis in B cells

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The receptor with high affinity for immunoglobulin E.

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Different roles for the Fc epsilon RI gamma chain as a function of the receptor context

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The gamma chain of the high-affinity receptor for IgE is a major functional subunit of the T-cell antigen receptor complex in gamma delta T lymphocytes

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FcR gamma chain deletion results in pleiotrophic effector cell defects

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Uncoupling of immune complex formation and kidney damage in autoimmune glomerulonephritis.

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Phosphorylation and dephosphorylation of the high-affinity receptor for immunoglobulin E immediately after receptor engagement and disengagement

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Tyrosine phosphorylation coupled to IgE receptor-mediated signal transduction and histamine release

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Transfection of Syk protein tyrosine kinase reconstitutes high affinity IgE receptor-mediated degranulation in a Syk-negative variant of rat basophilic leukemia RBL-2H3 cells

21 January 2018

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ER-27319, an acridone-related compound, inhibits release of antigen-induced allergic mediators from mast cells by selective inhibition of fcepsilon receptor I-mediated activation of Syk

21 January 2018

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Thy-1-mediated activation of rat basophilic leukemia cells does not require co-expression of the high-affinity IgE receptor

21 January 2018

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Direct interaction of Syk and Lyn protein tyrosine kinases in rat basophilic leukemia cells activated via type I Fc epsilon receptors.

21 January 2018

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IgE-induced histamine release from rat basophilic leukemia cell lines: isolation of releasing and nonreleasing clones

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Characterization of Fc gamma receptors on rat mucosal mast cells using a mutant Fc epsilon RI-deficient rat basophilic leukemia line.

21 January 2018

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Subcloning the RBL-2H3 mucosal mast cell line reduces Ca2+ response heterogeneity at the single-cell level

21 January 2018

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A cloning and epsilon-epitope-tagging insert for the expression of polymerase chain reaction-generated cDNA fragments in Escherichia coli and mammalian cells

21 January 2018

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Polyethylene glycol-mediated infection of non-permissive mammalian cells with semliki forest virus: application to signal transduction studies

21 January 2018

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The interaction of IgE with rat basophilic leukemia cells. I. Evidence for specific binding of IgE

21 January 2018

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New fluorescent dyes for lymphocyte migration studies. Analysis by flow cytometry and fluorescence microscopy

21 January 2018

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A fluorometric assay for the quantitation of cell adherence to endothelial cells

21 January 2018

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Association of a p95 Vav-containing Signaling Complex with the FcϵRI γ Chain in the RBL-2H3 Mast Cell Line

21 January 2018

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Regulation of the adapter molecule Grb2 by the Fc epsilon R1 in the mast cell line RBL2H3.

21 January 2018

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Conserved cytoplasmic tyrosine residues of the gamma subunit are required for a phagocytic signal mediated by Fc gamma RIIIA.

21 January 2018

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Adhesion molecules as regulators of mast-cell and basophil function

21 January 2018

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syk protein tyrosine kinase regulates Fc receptor gamma-chain-mediated transport to lysosomes

21 January 2018

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Evidence for involvement of two isoforms of Syk protein-tyrosine kinase in signal transduction through the high affinity IgE receptor on rat basophilic leukemia cells

21 January 2018

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Tyrosine phosphorylation of protein kinase C-delta in response to the activation of the high-affinity receptor for immunoglobulin E modifies its substrate recognition

21 January 2018

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Tyrosine phosphorylation-dependent and -independent associations of protein kinase C-delta with Src family kinases in the RBL-2H3 mast cell line: regulation of Src family kinase activity by protein kinase C-delta

21 January 2018

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Fc epsilon RI-mediated tyrosine phosphorylation and activation of the 72-kDa protein-tyrosine kinase, PTK72, in RBL-2H3 rat tumor mast cells

21 January 2018

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The Fc receptor gamma-chain and the tyrosine kinase Syk are essential for activation of mouse platelets by collagen

21 January 2018

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Glycoprotein VI is the collagen receptor in platelets which underlies tyrosine phosphorylation of the Fc receptor gamma-chain

21 January 2018

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Transphosphorylation as the mechanism by which the high-affinity receptor for IgE is phosphorylated upon aggregation

21 January 2018

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Interaction of phosphorylated FcepsilonRIgamma immunoglobulin receptor tyrosine activation motif-based peptides with dual and single SH2 domains of p72syk. Assessment of binding parameters and real time binding kinetics

21 January 2018

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Conformational changes induced in the protein tyrosine kinase p72syk by tyrosine phosphorylation or by binding of phosphorylated immunoreceptor tyrosine-based activation motif peptides

21 January 2018

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Solution structure of the C-terminal SH2 domain of the human tyrosine kinase Syk complexed with a phosphotyrosine pentapeptide

21 January 2018

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Structural basis for Syk tyrosine kinase ubiquity in signal transduction pathways revealed by the crystal structure of its regulatory SH2 domains bound to a dually phosphorylated ITAM peptide

21 January 2018

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Analysis of the interaction of ZAP-70 and syk protein-tyrosine kinases with the T-cell antigen receptor by plasmon resonance

21 January 2018

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An unusual mechanism for ligand antagonism.

21 January 2018

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Compartmentalized activation of the high affinity immunoglobulin E receptor within membrane domains

21 January 2018

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Serum IgE level drives basophil and mast cell IgE receptor display

21 January 2018

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Studies with a monoclonal antibody to the beta subunit of the receptor with high affinity for immunoglobulin E

21 January 2018

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Culture of bone marrow-derived mast cells: a model for studying oxidative metabolism of arachidonic acid and synthesis of other molecules derived from membrane phospholipids

21 January 2018

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Biochemical evidence that the phosphorylated tyrosines, serines, and threonines on the aggregated high affinity receptor for IgE are in the immunoreceptor tyrosine-based activation motifs

21 January 2018

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Tandem SH2 domains confer high specificity in tyrosine kinase signaling

21 January 2018

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Allergy-Associated FcRβ Is a Molecular Amplifier of IgE- and IgG-Mediated In Vivo Responses

21 January 2018

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21 January 2018

Identifiers

DOI

10.1074/JBC.274.33.23068

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10438475%20AND%20SRC:MED&resulttype=core&format=json

11 December 2019

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