Studies of Glutathione Transferase P1-1 Bound to a Platinum(IV)-Based Anticancer Compound Reveal the Molecular Basis of Its Activation (Q57838180)

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5 February 2020

title

Studies of glutathione transferase P1-1 bound to a platinum(IV)-based anticancer compound reveal the molecular basis of its activation (English)

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David B Ascher

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Hugh H. Harris

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Anastasia De Luca

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Wee Han Ang

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Paul Dyson

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Ursula Rothlisberger

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Pablo Peláez-Campomanes

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Pablo Campomanes

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Michael W Parker

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Lorien J Parker

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Jose Mario Bello Pineda

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Mario Lo Bello

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author name string

Louis C Italiano

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Nancy C Hancock

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Jade B Aitken

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language of work or name

English

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publication date

16 June 2011

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Chemistry—A European Journal

5 February 2020

published in

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volume

17

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5 February 2020

page(s)

7806-7816

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issue

28

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Testicular germ-cell cancer.

5 February 2020

cites work

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The resurgence of platinum-based cancer chemotherapy

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Biochemical modulation of Cisplatin mechanisms of action: enhancement of antitumor activity and circumvention of drug resistance

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Direct cellular responses to platinum-induced DNA damage

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Glutathione S-transferase polymorphisms: cancer incidence and therapy

21 January 2018

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Reversal of multiple drug resistance in cholangiocarcinoma by the glutathione S-transferase-pi-specific inhibitor O1-hexadecyl-gamma-glutamyl-S-benzylcysteinyl-D-phenylglycine ethylester.

21 January 2018

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Structure, function and evolution of glutathione transferases: implications for classification of non-mammalian members of an ancient enzyme superfamily

21 January 2018

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21 January 2018

Glutathione transferases

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Structure and function of glutathione S-transferases.

21 January 2018

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Glutathione transferases and cancer

21 January 2018

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Inhibition of rat and human glutathione S-transferase isoenzymes by ethacrynic acid and its glutathione conjugate.

21 January 2018

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Rational design of platinum(IV) compounds to overcome glutathione-S-transferase mediated drug resistance.

21 January 2018

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The three-dimensional structure of the human Pi class glutathione transferase P1-1 in complex with the inhibitor ethacrynic acid and its glutathione conjugate

21 January 2018

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Efficient exploration of reactive potential energy surfaces using Car-Parrinello molecular dynamics.

21 January 2018

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Escaping free-energy minima

21 January 2018

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Flexible docking in solution using metadynamics

21 January 2018

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Exploring complex protein-ligand recognition mechanisms with coarse metadynamics

21 January 2018

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The glutathione conjugate of ethacrynic acid can bind to human pi class glutathione transferase P1-1 in two different modes

21 January 2018

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The anti-cancer drug chlorambucil as a substrate for the human polymorphic enzyme glutathione transferase P1-1: kinetic properties and crystallographic characterisation of allelic variants

21 January 2018

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The CCP4 suite: programs for protein crystallography

21 January 2018

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The structures of human glutathione transferase P1-1 in complex with glutathione and various inhibitors at high resolution

21 January 2018

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PROCHECK: a program to check the stereochemical quality of protein structures

21 January 2018

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A point-charge force field for molecular mechanics simulations of proteins based on condensed-phase quantum mechanical calculations

21 January 2018

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Numerical integration of the cartesian equations of motion of a system with constraints: molecular dynamics of n-alkanes

21 January 2018

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An Efficient Real Space Multigrid QM/MM Electrostatic Coupling.

21 January 2018

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Generalized Gradient Approximation Made Simple

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/CHEM.201100586

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21681839%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

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