Helicase-Driven Activation of NFκB-COX2 Pathway Mediates the Immunosuppressive Component of dsRNA-Driven Inflammation in the Human Tumor Microenvironment (Q57753449)

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English	Helicase-Driven Activation of NFκB-COX2 Pathway Mediates the Immunosuppressive Component of dsRNA-Driven Inflammation in the Human Tumor Microenvironment	article

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scholarly article

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Helicase-Driven Activation of NFκB-COX2 Pathway Mediates the Immunosuppressive Component of dsRNA-Driven Inflammation in the Human Tumor Microenvironment (English)

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Francesmary Modugno

7

object named as

Francesmary Modugno

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Marie-Nicole Theodoraki

object named as

Marie-Nicole Theodoraki

1

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David L Bartlett

11

object named as

David L. Bartlett

David L Bartlett

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Saumendra N Sarkar

3

object named as

Saumendra N Sarkar

Saumendra N. Sarkar

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Ravikumar Muthuswamy

5

object named as

Ravikumar Muthuswamy

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Robert P Edwards

12

object named as

Robert P Edwards

Robert P. Edwards

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author name string

Saigopalakrishna Yerneni

2

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Brian Orr

4

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Jamie Voyten

6

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Weijian Jiang

8

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Melissa Grimm

9

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Per H Basse

10

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Pawel Kalinski

13

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Per H. Basse

10

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language of work or name

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publication date

1 August 2018

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31 May 2018

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Cancer Research

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78

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15

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4292-4302

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Tumor necrosis factor (TNF-alpha) and lymphotoxin (TNF-beta)

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https://pubmed.ncbi.nlm.nih.gov/29853604

12 December 2020

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IkappaB-NF-kappaB structures: at the interface of inflammation control

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https://pubmed.ncbi.nlm.nih.gov/29853604

12 December 2020

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Regulation of RANTES chemokine gene expression requires cooperativity between NF-kappa B and IFN-regulatory factor transcription factors

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https://pubmed.ncbi.nlm.nih.gov/29853604

12 December 2020

based on heuristic

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Distinct and essential roles of transcription factors IRF-3 and IRF-7 in response to viruses for IFN-alpha/beta gene induction

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https://pubmed.ncbi.nlm.nih.gov/29853604

12 December 2020

based on heuristic

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IFNs activate toll-like receptor gene expression in viral infections

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https://pubmed.ncbi.nlm.nih.gov/29853604

12 December 2020

based on heuristic

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A novel bulk-culture method for generating mature dendritic cells from mouse bone marrow cells.

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https://pubmed.ncbi.nlm.nih.gov/29853604

12 December 2020

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Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway

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https://pubmed.ncbi.nlm.nih.gov/29853604

12 December 2020

based on heuristic

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Upregulation of costimulatory molecules induced by lipopolysaccharide and double-stranded RNA occurs by Trif-dependent and Trif-independent pathways.

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https://pubmed.ncbi.nlm.nih.gov/29853604

12 December 2020

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IKKbeta links inflammation and tumorigenesis in a mouse model of colitis-associated cancer

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https://pubmed.ncbi.nlm.nih.gov/29853604

12 December 2020

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Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival

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https://pubmed.ncbi.nlm.nih.gov/29853604

12 December 2020

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TLR-independent induction of dendritic cell maturation and adaptive immunity by negative-strand RNA viruses.

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https://pubmed.ncbi.nlm.nih.gov/29853604

12 December 2020

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Toll-like receptor 3 promotes cross-priming to virus-infected cells.

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https://pubmed.ncbi.nlm.nih.gov/29853604

12 December 2020

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IFN-alpha enhances TLR3-mediated antiviral cytokine expression in human endothelial and epithelial cells by up-regulating TLR3 expression

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https://pubmed.ncbi.nlm.nih.gov/29853604

12 December 2020

based on heuristic

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Selective infiltration of CCR5(+)CXCR3(+) T lymphocytes in human colorectal carcinoma.

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https://pubmed.ncbi.nlm.nih.gov/29853604

12 December 2020

based on heuristic

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NF-kappaB: linking inflammation and immunity to cancer development and progression

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https://pubmed.ncbi.nlm.nih.gov/29853604

12 December 2020

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Regulation of the type I IFN induction: a current view

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https://pubmed.ncbi.nlm.nih.gov/29853604

12 December 2020

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Specificity in Toll-like receptor signalling through distinct effector functions of TRAF3 and TRAF6

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https://pubmed.ncbi.nlm.nih.gov/29853604

12 December 2020

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Intraepithelial CD8+ tumor-infiltrating lymphocytes and a high CD8+/regulatory T cell ratio are associated with favorable prognosis in ovarian cancer

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https://pubmed.ncbi.nlm.nih.gov/29853604

12 December 2020

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Effector memory T cells, early metastasis, and survival in colorectal cancer

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https://pubmed.ncbi.nlm.nih.gov/29853604

12 December 2020

based on heuristic

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Roles of caspase-8 and caspase-10 in innate immune responses to double-stranded RNA

1 reference

https://pubmed.ncbi.nlm.nih.gov/29853604

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Essential role of mda-5 in type I IFN responses to polyriboinosinic:polyribocytidylic acid and encephalomyocarditis picornavirus

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https://pubmed.ncbi.nlm.nih.gov/29853604

12 December 2020

based on heuristic

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Regulation of antiviral responses by a direct and specific interaction between TRAF3 and Cardif

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https://pubmed.ncbi.nlm.nih.gov/29853604

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

1 reference

https://pubmed.ncbi.nlm.nih.gov/29853604

12 December 2020

based on heuristic

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Nuclear factor-kappaB in development, prevention, and therapy of cancer

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https://pubmed.ncbi.nlm.nih.gov/29853604

12 December 2020

based on heuristic

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TLR3 is essential for the induction of protective immunity against Punta Toro Virus infection by the double-stranded RNA (dsRNA), poly(I:C12U), but not Poly(I:C): differential recognition of synthetic dsRNA molecules

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https://pubmed.ncbi.nlm.nih.gov/29853604

12 December 2020

based on heuristic

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The NEMO adaptor bridges the nuclear factor-kappaB and interferon regulatory factor signaling pathways

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https://pubmed.ncbi.nlm.nih.gov/29853604

12 December 2020

based on heuristic

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Key differences in TLR3/poly I:C signaling and cytokine induction by human primary cells: a phenomenon absent from murine cell systems

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https://pubmed.ncbi.nlm.nih.gov/29853604

12 December 2020

based on heuristic

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Signaling to NF-kappaB by Toll-like receptors

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https://pubmed.ncbi.nlm.nih.gov/29853604

12 December 2020

based on heuristic

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The microbial mimic poly IC induces durable and protective CD4+ T cell immunity together with a dendritic cell targeted vaccine

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https://pubmed.ncbi.nlm.nih.gov/29853604

12 December 2020

based on heuristic

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Virus Infection Induces NF-kappaB-dependent interchromosomal associations mediating monoallelic IFN-beta gene expression

1 reference

https://pubmed.ncbi.nlm.nih.gov/29853604

12 December 2020

based on heuristic

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Independent regulation of chemokine responsiveness and cytolytic function versus CD8+ T cell expansion by dendritic cells

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https://pubmed.ncbi.nlm.nih.gov/29853604

12 December 2020

based on heuristic

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Positive feedback between PGE2 and COX2 redirects the differentiation of human dendritic cells toward stable myeloid-derived suppressor cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29853604

12 December 2020

based on heuristic

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Defining emerging roles for NF-κB in antivirus responses: revisiting the interferon-β enhanceosome paradigm

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https://pubmed.ncbi.nlm.nih.gov/29853604

12 December 2020

based on heuristic

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PGE(2)-induced CXCL12 production and CXCR4 expression controls the accumulation of human MDSCs in ovarian cancer environment

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https://pubmed.ncbi.nlm.nih.gov/29853604

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of immune responses by prostaglandin E2

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https://pubmed.ncbi.nlm.nih.gov/29853604

12 December 2020

based on heuristic

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T-regulatory cells: key players in tumor immune escape and angiogenesis

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https://pubmed.ncbi.nlm.nih.gov/29853604

12 December 2020

based on heuristic

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NF-κB hyperactivation in tumor tissues allows tumor-selective reprogramming of the chemokine microenvironment to enhance the recruitment of cytolytic T effector cells

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https://pubmed.ncbi.nlm.nih.gov/29853604

12 December 2020

based on heuristic

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Safety, activity, and immune correlates of anti-PD-1 antibody in cancer

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https://pubmed.ncbi.nlm.nih.gov/29853604

12 December 2020

based on heuristic

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Molecular pathways: toll-like receptors in the tumor microenvironment--poor prognosis or new therapeutic opportunity.

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https://pubmed.ncbi.nlm.nih.gov/29853604

12 December 2020

based on heuristic

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Discordant biological and toxicological species responses to TLR3 activation

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https://pubmed.ncbi.nlm.nih.gov/29853604

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Targeted prostaglandin E2 inhibition enhances antiviral immunity through induction of type I interferon and apoptosis in macrophages.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29853604

12 December 2020

based on heuristic

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Antiviral activity of human OASL protein is mediated by enhancing signaling of the RIG-I RNA sensor

1 reference

https://pubmed.ncbi.nlm.nih.gov/29853604

12 December 2020

based on heuristic

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Predictive correlates of response to the anti-PD-L1 antibody MPDL3280A in cancer patients

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https://pubmed.ncbi.nlm.nih.gov/29853604

12 December 2020

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Combination of IFNα and poly-I:C reprograms bladder cancer microenvironment for enhanced CTL attraction

1 reference

https://pubmed.ncbi.nlm.nih.gov/29853604

12 December 2020

based on heuristic

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Cyclooxygenase-Dependent Tumor Growth through Evasion of Immunity.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29853604

12 December 2020

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Synergistic COX2 Induction by IFNγ and TNFα Self-Limits Type-1 Immunity in the Human Tumor Microenvironment

1 reference

https://pubmed.ncbi.nlm.nih.gov/29853604

12 December 2020

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Trial Watch: Immunostimulation with Toll-like receptor agonists in cancer therapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/29853604

12 December 2020

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Functional reprogramming of human prostate cancer to promote local attraction of effector CD8(+) T cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29853604

12 December 2020

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Recommendations for myeloid-derived suppressor cell nomenclature and characterization standards

1 reference

https://pubmed.ncbi.nlm.nih.gov/29853604

12 December 2020

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Promoting the accumulation of tumor-specific T cells in tumor tissues by dendritic cell vaccines and chemokine-modulating agents.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29853604

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1158/0008-5472.CAN-17-3985

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