A phase II study of the potent PARP inhibitor, Rucaparib (PF-01367338, AG014699), with temozolomide in patients with metastatic melanoma demonstrating evidence of chemopotentiation (Q57569610)

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English	A phase II study of the potent PARP inhibitor, Rucaparib (PF-01367338, AG014699), with temozolomide in patients with metastatic melanoma demonstrating evidence of chemopotentiation	article

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scholarly article

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24 February 2020

A phase II study of the potent PARP inhibitor, Rucaparib (PF-01367338, AG014699), with temozolomide in patients with metastatic melanoma demonstrating evidence of chemopotentiation (English)

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24 February 2020

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metastatic melanoma

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based on heuristic

inferred from title

2

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author name string

Ruth Plummer

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24 February 2020

Neil Steven

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Lucy Scott

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Evan Mulligan

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Diane Wang

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Raz Dewji

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Antonello Abbattista

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Jorge Gallo

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Hilary Calvert

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Mark R Middleton

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Richard H Wilson

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publication date

20 February 2013

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24 February 2020

Cancer Chemotherapy and Pharmacology

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71

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1191-1199

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5

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24 February 2020

https://scigraph.springernature.com/pub.10.1007/s00280-013-2113-1

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Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and recurrent ovarian cancer: a proof-of-concept trial

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Bcl-2 antisense (oblimersen sodium) plus dacarbazine in patients with advanced melanoma: the Oblimersen Melanoma Study Group

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DNA repair/pro-apoptotic dual-role proteins in five major DNA repair pathways: fail-safe protection against carcinogenesis

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Poly(ADP-ribose) polymerase: a molecular nick-sensor

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Palliative therapy of disseminated malignant melanoma: a systematic review of 41 randomised clinical trials.

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Inhibition of Mutated, Activated BRAF in Metastatic Melanoma

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Phase II trial of the O6-alkylguanine DNA alkyltransferase inhibitor O6-benzylguanine and 1,3-bis(2-chloroethyl)-1-nitrosourea in advanced melanoma.

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Olaparib in patients with recurrent high-grade serous or poorly differentiated ovarian carcinoma or triple-negative breast cancer: a phase 2, multicentre, open-label, non-randomised study

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MGMT gene silencing and benefit from temozolomide in glioblastoma

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Improved Survival with Ipilimumab in Patients with Metastatic Melanoma

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Single-agent DTIC versus combination chemotherapy with or without immunotherapy in metastatic melanoma: a meta-analysis of 3273 patients from 20 randomized trials

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Patterns of expression of DNA repair genes and relapse from melanoma

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Phase II trial of tremelimumab (CP-675,206) in patients with advanced refractory or relapsed melanoma

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Meta-analysis of phase II cooperative group trials in metastatic stage IV melanoma to determine progression-free and overall survival benchmarks for future phase II trials

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Systemic therapy for metastatic malignant melanoma--from deeply disappointing to bright future?

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Mechanisms of carcinogenicity/chemotherapy by O6-methylguanine

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Randomized phase III study of temozolomide versus dacarbazine in the treatment of patients with advanced metastatic malignant melanoma

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Temozolomide: a review of its discovery, chemical properties, pre-clinical development and clinical trials

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https://api.crossref.org/works/10.1007%2FS00280-013-2113-1

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Extended schedule, escalated dose temozolomide versus dacarbazine in stage IV melanoma: final results of a randomised phase III study (EORTC 18032).

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Temozolomide pharmacodynamics in patients with metastatic melanoma: dna damage and activity of repair enzymes O6-alkylguanine alkyltransferase and poly(ADP-ribose) polymerase-1.

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Phase I study of the poly(ADP-ribose) polymerase inhibitor, AG014699, in combination with temozolomide in patients with advanced solid tumors.

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Survival plots of time-to-event outcomes in clinical trials: good practice and pitfalls

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Phase I trial of temozolomide plus O6-benzylguanine for patients with recurrent or progressive malignant glioma

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Phase II trial of carmustine plus O(6)-benzylguanine for patients with nitrosourea-resistant recurrent or progressive malignant glioma

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Randomized Trial of the Combination of Lomeguatrib and Temozolomide Compared With Temozolomide Alone in Chemotherapy Naive Patients With Metastatic Cutaneous Melanoma

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21 January 2018

Lomeguatrib, a potent inhibitor of O6-alkylguanine-DNA-alkyltransferase: phase I safety, pharmacodynamic, and pharmacokinetic trial and evaluation in combination with temozolomide in patients with advanced solid tumors

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Changing paradigms--an update on the multidisciplinary management of malignant glioma

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New guidelines to evaluate the response to treatment in solid tumors. European Organization for Research and Treatment of Cancer, National Cancer Institute of the United States, National Cancer Institute of Canada

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21 January 2018

Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and advanced breast cancer: a proof-of-concept trial

1 reference

https://api.crossref.org/works/10.1007%2FS00280-013-2113-1

21 January 2018

Multicenter phase II trial of temozolomide in patients with anaplastic astrocytoma or anaplastic oligoastrocytoma at first relapse. Temodal Brain Tumor Group

1 reference

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10.1007/S00280-013-2113-1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23423489%20AND%20SRC:MED&resulttype=core&format=json

24 February 2020

1 reference

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24 February 2020

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