Combination therapy to checkmate Glioblastoma: clinical challenges and advances (Q57456667)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30327965%20AND%20SRC:MED&resulttype=core&format=json

29 April 2020

title

Combination therapy to checkmate Glioblastoma: clinical challenges and advances (English)

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29 April 2020

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2

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29 April 2020

Sonali Bhattacharjee

series ordinal

3

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29 April 2020

author name string

Debarati Ghosh

series ordinal

1

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29 April 2020

language of work or name

English

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publication date

16 October 2018

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Clinical and translational medicine

29 April 2020

published in

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29 April 2020

volume

7

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29 April 2020

issue

1

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29 April 2020

page(s)

33

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29 April 2020

1 reference

12 December 2020

Transforming growth factor-beta-mediated autocrine growth regulation of gliomas as detected with phosphorothioate antisense oligonucleotides.

1 reference

12 December 2020

Mutagenic damage to mammalian cells by therapeutic alkylating agents

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12 December 2020

Primary and secondary glioblastomas: from concept to clinical diagnosis

1 reference

12 December 2020

Pten signaling in gliomas

1 reference

12 December 2020

Combination versus sequential single-agent therapy in metastatic breast cancer.

1 reference

12 December 2020

Genetic markers in glioblastoma: prognostic significance and future therapeutic implications

1 reference

12 December 2020

The problem of synergism and antagonism of combined drugs

1 reference

12 December 2020

Prognostic value of epidermal growth factor receptor in patients with glioblastoma multiforme

1 reference

12 December 2020

Silencing effect of CpG island hypermethylation and histone modifications on O6-methylguanine-DNA methyltransferase (MGMT) gene expression in human cancer

1 reference

12 December 2020

Genetic pathways to glioblastoma: a population-based study

1 reference

12 December 2020

Identification of human brain tumour initiating cells

1 reference

12 December 2020

Epidemiology and etiology of gliomas

1 reference

12 December 2020

MGMT gene silencing and benefit from temozolomide in glioblastoma

1 reference

12 December 2020

The natural history of EGFR and EGFRvIII in glioblastoma patients

1 reference

12 December 2020

Molecular subclasses of high-grade glioma predict prognosis, delineate a pattern of disease progression, and resemble stages in neurogenesis

1 reference

12 December 2020

Temozolomide: a milestone in the pharmacotherapy of brain tumors

1 reference

12 December 2020

Defining the actual sensitivity and specificity of the neurosphere assay in stem cell biology

1 reference

12 December 2020

Glioma stem cells promote radioresistance by preferential activation of the DNA damage response

1 reference

12 December 2020

Analysis of gene expression and chemoresistance of CD133+ cancer stem cells in glioblastoma

1 reference

12 December 2020

A perivascular niche for brain tumor stem cells

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12 December 2020

Systemic CTLA-4 blockade ameliorates glioma-induced changes to the CD4+ T cell compartment without affecting regulatory T-cell function

1 reference

12 December 2020

Genetic pathways to primary and secondary glioblastoma

1 reference

12 December 2020

The 2007 WHO classification of tumours of the central nervous system

1 reference

12 December 2020

Coactivation of receptor tyrosine kinases affects the response of tumor cells to targeted therapies

1 reference

12 December 2020

Brain tumor therapy by combined vaccination and antisense oligonucleotide delivery with nanoparticles

1 reference

12 December 2020

Gli activity correlates with tumor grade in platelet-derived growth factor-induced gliomas

1 reference

12 December 2020

Correlation of O6-methylguanine methyltransferase (MGMT) promoter methylation with clinical outcomes in glioblastoma and clinical strategies to modulate MGMT activity

1 reference

12 December 2020

An integrated genomic analysis of human glioblastoma multiforme

1 reference

12 December 2020

Inhibition of PI3K-AKT-mTOR signaling sensitizes melanoma cells to cisplatin and temozolomide

1 reference

12 December 2020

IDH1 mutations are early events in the development of astrocytomas and oligodendrogliomas

1 reference

12 December 2020

Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial

1 reference

12 December 2020

Potential therapeutic targets for chordoma: PI3K/AKT/TSC1/TSC2/mTOR pathway

1 reference

12 December 2020

The safety of temozolomide in the treatment of malignancies

1 reference

12 December 2020

Hypoxia-inducible factors regulate tumorigenic capacity of glioma stem cells

1 reference

12 December 2020

Genetic alterations and signaling pathways in the evolution of gliomas

1 reference

12 December 2020

Brain cancer propagating cells: biology, genetics and targeted therapies

1 reference

12 December 2020

NOTCH pathway blockade depletes CD133-positive glioblastoma cells and inhibits growth of tumor neurospheres and xenografts

1 reference

12 December 2020

Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1

1 reference

12 December 2020

Targeting the RB-pathway in cancer therapy

1 reference

12 December 2020

Identification of a CpG island methylator phenotype that defines a distinct subgroup of glioma

1 reference

12 December 2020

Photothermolysis of glioblastoma stem-like cells targeted by carbon nanotubes conjugated with CD133 monoclonal antibody

1 reference

12 December 2020

Glioma cancer stem cells induce immunosuppressive macrophages/microglia

1 reference

12 December 2020

Tumor heterogeneity is an active process maintained by a mutant EGFR-induced cytokine circuit in glioblastoma

1 reference

12 December 2020

Glioblastoma with granular cell astrocytoma features: a case report and literature review

1 reference

12 December 2020

Glioblastoma stem-like cells give rise to tumour endothelium.

1 reference

12 December 2020

Acidic stress promotes a glioma stem cell phenotype.

1 reference

12 December 2020

Phase II study of bevacizumab plus temozolomide during and after radiation therapy for patients with newly diagnosed glioblastoma multiforme

1 reference

12 December 2020

Inhibition of PI3K/mTOR pathways in glioblastoma and implications for combination therapy with temozolomide

1 reference

12 December 2020

Nonreceptor tyrosine kinase BMX maintains self-renewal and tumorigenic potential of glioblastoma stem cells by activating STAT3.

1 reference

12 December 2020

Myeloid-derived suppressor cell accumulation and function in patients with newly diagnosed glioblastoma

1 reference

12 December 2020

Developmental and pathological angiogenesis

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12 December 2020

Glioma stem cell maintenance: the role of the microenvironment

1 reference

12 December 2020

Improved survival time trends for glioblastoma using the SEER 17 population-based registries

1 reference

12 December 2020

Glioblastoma with PNET-like components has a higher frequency of isocitrate dehydrogenase 1 (IDH1) mutation and likely a better prognosis than primary glioblastoma.

1 reference

12 December 2020

The blockade of immune checkpoints in cancer immunotherapy

1 reference

12 December 2020

Malignant glioma: lessons from genomics, mouse models, and stem cells

1 reference

12 December 2020

A BMP7 variant inhibits the tumorigenic potential of glioblastoma stem-like cells.

1 reference

12 December 2020

A restricted cell population propagates glioblastoma growth after chemotherapy

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12 December 2020

Frequent ATRX, CIC, FUBP1 and IDH1 mutations refine the classification of malignant gliomas

1 reference

12 December 2020

The definition of primary and secondary glioblastoma

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12 December 2020

CD133 is essential for glioblastoma stem cell maintenance.

1 reference

12 December 2020

IGF1 receptor signaling regulates adaptive radioprotection in glioma stem cells

1 reference

12 December 2020

Intratumor heterogeneity in human glioblastoma reflects cancer evolutionary dynamics.

1 reference

12 December 2020

Development of a new UPLC-MSMS method for the determination of temozolomide in mice: application to plasma pharmacokinetics and brain distribution study.

1 reference

12 December 2020

Anti-PD-1 blockade and stereotactic radiation produce long-term survival in mice with intracranial gliomas

1 reference

12 December 2020

IDH1 and IDH2 mutations in gliomas

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12 December 2020

Epithelioid GBMs show a high percentage of BRAF V600E mutation.

1 reference

12 December 2020

The expression status of CD133 is associated with the pattern and timing of primary glioblastoma recurrence.

1 reference

12 December 2020

ATRX loss refines the classification of anaplastic gliomas and identifies a subgroup of IDH mutant astrocytic tumors with better prognosis

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12 December 2020

Mesenchymal differentiation mediated by NF-κB promotes radiation resistance in glioblastoma.

1 reference

12 December 2020

MHF1-2/CENP-S-X performs distinct roles in centromere metabolism and genetic recombination

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12 December 2020

Using the molecular classification of glioblastoma to inform personalized treatment

1 reference

12 December 2020

The somatic genomic landscape of glioblastoma

1 reference

12 December 2020

CBTRUS statistical report: Primary brain and central nervous system tumors diagnosed in the United States in 2006-2010.

1 reference

12 December 2020

High-throughput combinatorial screening identifies drugs that cooperate with ibrutinib to kill activated B-cell-like diffuse large B-cell lymphoma cells

1 reference

12 December 2020

MGMT testing--the challenges for biomarker-based glioma treatment

1 reference

12 December 2020

Reproducibility of results in preclinical studies: a perspective from the bone field

1 reference

12 December 2020

Single-cell RNA-seq highlights intratumoral heterogeneity in primary glioblastoma

1 reference

12 December 2020

TLR9 is critical for glioma stem cell maintenance and targeting

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12 December 2020

RIST: a potent new combination therapy for glioblastoma

1 reference

12 December 2020

A tumor-targeting p53 nanodelivery system limits chemoresistance to temozolomide prolonging survival in a mouse model of glioblastoma multiforme

1 reference

12 December 2020

Dicer promotes transcription termination at sites of replication stress to maintain genome stability

1 reference

12 December 2020

Myeloid derived suppressor cell infiltration of murine and human gliomas is associated with reduction of tumor infiltrating lymphocytes

1 reference

12 December 2020

Periostin secreted by glioblastoma stem cells recruits M2 tumour-associated macrophages and promotes malignant growth

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12 December 2020

Whole-genome and multisector exome sequencing of primary and post-treatment glioblastoma reveals patterns of tumor evolution

1 reference

12 December 2020

Sulforaphane enhances temozolomide-induced apoptosis because of down-regulation of miR-21 via Wnt/β-catenin signaling in glioblastoma

1 reference

12 December 2020

Cancer stem cells in glioblastoma

1 reference

12 December 2020

Primary and secondary gliosarcomas: clinical, molecular and survival characteristics

1 reference

12 December 2020

Efflux transporters at the blood-brain barrier limit delivery and efficacy of cyclin-dependent kinase 4/6 inhibitor palbociclib (PD-0332991) in an orthotopic brain tumor model

1 reference

12 December 2020

The mitotic kinesin KIF11 is a driver of invasion, proliferation, and self-renewal in glioblastoma.

1 reference

12 December 2020

High-throughput matrix screening identifies synergistic and antagonistic antimalarial drug combinations

1 reference

12 December 2020

Immunotherapy for neuro-oncology: the critical rationale for combinatorial therapy

1 reference

12 December 2020

Synergistic Effect of Immunoliposomal Gemcitabine and Bevacizumab in Glioblastoma Stem Cell-Targeted Therapy.

1 reference

12 December 2020

Emerging targets for glioblastoma stem cell therapy

1 reference

12 December 2020

Sulforaphane reverses chemo-resistance to temozolomide in glioblastoma cells by NF-κB-dependent pathway downregulating MGMT expression

1 reference

12 December 2020

Insulator dysfunction and oncogene activation in IDH mutant gliomas

1 reference

12 December 2020

Nimotuzumab enhances temozolomide-induced growth suppression of glioma cells expressing mutant EGFR in vivo

1 reference

12 December 2020

Metabolic/Proteomic Signature Defines Two Glioblastoma Subtypes With Different Clinical Outcome.

1 reference

12 December 2020

Searching for Drug Synergy in Complex Dose-Response Landscapes Using an Interaction Potency Model

1 reference

12 December 2020

Trial Watch: Glioblastoma vaccine therapy disappointment in Phase III trial

1 reference

12 December 2020

Improving the Predictive Value of Preclinical Studies in Support of Radiotherapy Clinical Trials

1 reference

12 December 2020

The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary

1 reference

12 December 2020

Combination therapy in a xenograft model of glioblastoma: enhancement of the antitumor activity of temozolomide by an MDM2 antagonist

1 reference

12 December 2020

ATRX mutations and glioblastoma: Impaired DNA damage repair, alternative lengthening of telomeres, and genetic instability.

1 reference

12 December 2020

Functional Subclone Profiling for Prediction of Treatment-Induced Intratumor Population Shifts and Discovery of Rational Drug Combinations in Human Glioblastoma

1 reference

12 December 2020

Basket Trials in Oncology: A Trade-Off Between Complexity and Efficiency

1 reference

12 December 2020

Choices have consequences: the nexus between DNA repair pathways and genomic instability in cancer

1 reference

12 December 2020

Advances in Experimental Targeted Therapy and Immunotherapy for Patients with Glioblastoma Multiforme.

1 reference

12 December 2020

Immunosuppressive Myeloid Cells' Blockade in the Glioma Microenvironment Enhances the Efficacy of Immune-Stimulatory Gene Therapy

1 reference

12 December 2020

Intratumoral heterogeneity: pathways to treatment resistance and relapse in human glioblastoma

1 reference

12 December 2020

Combination therapy in combating cancer

1 reference

12 December 2020

Combination therapy with micellarized cyclopamine and temozolomide attenuate glioblastoma growth through Gli1 down-regulation

1 reference

12 December 2020

Current status and future therapeutic perspectives of glioblastoma multiforme (GBM) therapy: A review

1 reference

12 December 2020

Combination of palbociclib and radiotherapy for glioblastoma

1 reference

12 December 2020

Tumor Evolution of Glioma-Intrinsic Gene Expression Subtypes Associates with Immunological Changes in the Microenvironment.

1 reference

12 December 2020

A Review of Anti-Angiogenic Targets for Monoclonal Antibody Cancer Therapy

1 reference

12 December 2020

Poly-(ADP-ribose)-polymerase inhibitors as radiosensitizers: a systematic review of pre-clinical and clinical human studies.

1 reference

12 December 2020

DNA damage response and cancer therapeutics through the lens of the Fanconi Anemia DNA repair pathway

1 reference

12 December 2020

The Role of ATRX in Glioma Biology

1 reference

12 December 2020

Glioma CpG Island Methylator Phenotype (G-CIMP): Biological and Clinical Implications

1 reference

12 December 2020

Tumor response of temozolomide in combination with morphine in a xenograft model of human glioblastoma

1 reference

12 December 2020

Synthetic lethality in DNA repair network: A novel avenue in targeted cancer therapy and combination therapeutics

1 reference

12 December 2020

Inhibition of translesion DNA synthesis as a novel therapeutic strategy to treat brain cancer

1 reference

12 December 2020

Glioblastoma under Siege: An Overview of Current Therapeutic Strategies.

1 reference

12 December 2020

Radiosensitization Effect of Talazoparib, a Parp Inhibitor, on Glioblastoma Stem Cells Exposed to Low and High Linear Energy Transfer Radiation.

1 reference

12 December 2020

Therapeutic Potential of Thymoquinone in Glioblastoma Treatment: Targeting Major Gliomagenesis Signaling Pathways.

1 reference

12 December 2020

Enhanced efficacy of combined temozolomide and bromodomain inhibitor therapy for gliomas using targeted nanoparticles.

1 reference

12 December 2020

MicroRNA-599 suppresses glioma progression by targeting RAB27B.

1 reference

12 December 2020

Brain Targeting by Liposome-Biomolecular Corona Boosts Anticancer Efficacy of Temozolomide in Glioblastoma Cells

1 reference

12 December 2020

Current status and potential challenges of mesenchymal stem cell-based therapy for malignant gliomas

1 reference

12 December 2020

Rare Genetic Diseases with Defects in DNA Repair: Opportunities and Challenges in Orphan Drug Development for Targeted Cancer Therapy

1 reference

12 December 2020

10.1186/S40169-018-0211-8

Identifiers

DOI

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30327965%20AND%20SRC:MED&resulttype=core&format=json

29 April 2020

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30327965%20AND%20SRC:MED&resulttype=core&format=json

29 April 2020

PubMed publication ID

30327965

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