Defective Signaling to Fyn by a T Cell Antigen Receptor Lacking the α-Chain Connecting Peptide Motif (Q57371947)

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Annick Peter

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Emanuele Orsini

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Ed Palmer

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Cosima T. Baldari

Journal of Biological Chemistry

5

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language of work or name

English

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publication date

31 October 2000

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published in

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volume

276

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issue

5

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page(s)

3574-3580

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cites work

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T cell antigen receptor signal transduction

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Molecular and genetic insights into T cell antigen receptor structure and function

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Positive selection through a motif in the alphabeta T cell receptor

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Differential regulation of T cell antigen responsiveness by isoforms of the src-related tyrosine protein kinase p59fyn

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Reconstitution of T cell receptor zeta-mediated calcium mobilization in nonlymphoid cells.

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Ecological Controls on the Evolutionary Recovery of Post-Paleozoic Crinoids

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Interactions between the tyrosine kinases p56lck, p59fyn and p50csk in CD4 signaling in T cells

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Phosphorylation of Tyr319 in ZAP-70 is required for T-cell antigen receptor-dependent phospholipase C-gamma1 and Ras activation

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Phospholipase C-gamma1 interacts with conserved phosphotyrosyl residues in the linker region of Syk and is a substrate for Syk

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Requirement for Tec kinases Rlk and Itk in T cell receptor signaling and immunity

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Association of the fyn protein-tyrosine kinase with the T-cell antigen receptor

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Cloning of a novel T-cell protein FYB that binds FYN and SH2-domain-containing leukocyte protein 76 and modulates interleukin 2 production

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Molecular cloning of SKAP55, a novel protein that associates with the protein tyrosine kinase p59fyn in human T-lymphocytes

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Tyrosine phosphorylation of Pyk2 is selectively regulated by Fyn during TCR signaling

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Protein-tyrosine kinase Pyk2 is involved in interleukin-2 production by Jurkat T cells via its tyrosine 402

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Engagement of the TcR/CD3 complex stimulates p59fyn(T) activity: detection of associated proteins at 72 and 120-130 kD.

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Ligation of the T-cell Antigen Receptor (TCR) Induces Association of hSos1, ZAP-70, Phospolipase C- 1, and Other Phosphoproteins with Grb2 and the -Chain of the TCR

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A motif in the alphabeta T-cell receptor controls positive selection by modulating ERK activity

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CD3 delta deficiency arrests development of the alpha beta but not the gamma delta T cell lineage

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Crippling of CD3-ζ ITAMs Does Not Impair T Cell Receptor Signaling

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Generation of antigen-specific cytotoxic T lymphocytes and regulation of cytokine production takes place in the absence of CD3zeta.

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Regulation of T cell receptor signaling by a src family protein-tyrosine kinase (p59fyn).

21 January 2018

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Defective T cell receptor signaling in mice lacking the thymic isoform of p59fyn

21 January 2018

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Unique catalytic properties dictate the enhanced function of p59fynT, the hemopoietic cell-specific isoform of the Fyn tyrosine protein kinase, in T cells

21 January 2018

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Structure of the complex between human T-cell receptor, viral peptide and HLA-A2

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Lck-independent triggering of T-cell antigen receptor signal transduction by staphylococcal enterotoxins

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Ras regulation and function in lymphocytes.

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Functional rafts in cell membranes

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Lck regulates the tyrosine phosphorylation of the T cell receptor subunits and ZAP-70 in murine thymocytes

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Profound block in thymocyte development in mice lacking p56lck

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M008588200

alpha beta T cell development is abolished in mice lacking both Lck and Fyn protein tyrosine kinases

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M008588200

Different cytoplasmic structure of the CD3ζ family dimer modulates the activation signal and function of T cells

21 January 2018

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Calcium dependent activation of the NF-AT transcription factor by p59fyn

21 January 2018

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Characterization of p59fyn-mediated signal transduction on T cell activation

21 January 2018

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Altered functional responsiveness of thymocyte subsets from CD3delta-deficient mice to TCR-CD3 engagement

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M008588200

pp59fyn mutant mice display differential signaling in thymocytes and peripheral T cells

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M008588200

T cell activation by clustered tyrosine kinases

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M008588200

Fyn can partially substitute for Lck in T lymphocyte development

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M008588200