PI3Kγ inhibition reduces blood pressure by a vasorelaxant Akt/L-type calcium channel mechanism (Q57005928)

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15 January 2020

title

PI3Kγ inhibition reduces blood pressure by a vasorelaxant Akt/L-type calcium channel mechanism (English)

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15 January 2020

1

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15 January 2020

Carmine Vecchione

2

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15 January 2020

Giada Mascio

3

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Giuseppe Cifelli

5

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Katiuscia Martinello

6

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Antonio Damato

10

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Angelo Maffei

13

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Elisa Ciraolo

14

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Sergio Fucile

15

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Giacomo Frati

16

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Emilio Hirsch

18

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Giuseppe Lembo

19

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15 January 2020

author name string

Giovanni Esposito

4

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Alessandro Landolfi

7

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Giulio Selvetella

8

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Paolo Grieco

9

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Elio Franco

11

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Hannelore Haase

12

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Orazio Mazzoni

17

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publication date

27 October 2011

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15 January 2020

published in

Cardiovascular Research

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volume

93

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page(s)

200-209

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issue

1

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The emerging mechanisms of isoform-specific PI3K signalling

15 January 2020

cites work

1 reference

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Phosphoinositide 3-kinase gamma/delta inhibition limits infarct size after myocardial ischemia/reperfusion injury

21 January 2018

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Involvement of phosphoinositide 3-kinase gamma in angiogenesis and healing of experimental myocardial infarction in mice

21 January 2018

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Genetic and pharmacological targeting of phosphoinositide 3-kinase-gamma reduces atherosclerosis and favors plaque stability by modulating inflammatory processes

21 January 2018

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Distinct effects of leukocyte and cardiac phosphoinositide 3-kinase γ activity in pressure overload-induced cardiac failure

21 January 2018

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Protection from angiotensin II-mediated vasculotoxic and hypertensive response in mice lacking PI3Kgamma

21 January 2018

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Negative feedback regulation of Rac in leukocytes from mice expressing a constitutively active phosphatidylinositol 3-kinase gamma

21 January 2018

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Emilin1 links TGF-beta maturation to blood pressure homeostasis

21 January 2018

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Phosphoinositide 3-kinase isoforms selectively couple receptors to vascular L-type Ca(2+) channels

21 January 2018

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Ahnak is critical for cardiac Ca(V)1.2 calcium channel function and its beta-adrenergic regulation

21 January 2018

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Structural Determinants of Phosphoinositide 3-Kinase Inhibition by Wortmannin, LY294002, Quercetin, Myricetin, and Staurosporine

21 January 2018

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Therapeutic potential of pharmacologically targeting arteriolar myogenic tone.

21 January 2018

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Pressure-induced vascular oxidative stress is mediated through activation of integrin-linked kinase 1/betaPIX/Rac-1 pathway.

21 January 2018

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Regulation of vascular L-type Ca2+ channels by phosphatidylinositol 3,4,5-trisphosphate

21 January 2018

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PI3K promotes voltage-dependent calcium channel trafficking to the plasma membrane

21 January 2018

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Akt regulates L-type Ca2+ channel activity by modulating Cavalpha1 protein stability.

21 January 2018

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Phosphoinositide 3-kinase gamma mediates angiotensin II-induced stimulation of L-type calcium channels in vascular myocytes

21 January 2018

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Canonical TRP channels and mechanotransduction: from physiology to disease states.

21 January 2018

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Regulation of myocardial contractility and cell size by distinct PI3K-PTEN signaling pathways

21 January 2018

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Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure

21 January 2018

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Mechanisms of target organ damage caused by hypertension: therapeutic potential

21 January 2018

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Nonsteroidal antiinflammatory drugs, acetaminophen, and the risk of cardiovascular events

21 January 2018

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Cardiovascular risk associated with celecoxib

21 January 2018

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21 January 2018

Identifiers

DOI

10.1093/CVR/CVR288

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15 January 2020

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