The stability of mRNA encoding IL-4 is increased in pulmonary tuberculosis, while stability of mRNA encoding the antagonistic splice variant, IL-4δ2, is not (Q56404248)

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scholarly article by Keertan Dheda et al published May 2007 in Tuberculosis

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English	The stability of mRNA encoding IL-4 is increased in pulmonary tuberculosis, while stability of mRNA encoding the antagonistic splice variant, IL-4δ2, is not	scholarly article by Keertan Dheda et al published May 2007 in Tuberculosis

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scholarly article

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The stability of mRNA encoding IL-4 is increased in pulmonary tuberculosis, while stability of mRNA encoding the antagonistic splice variant, IL-4δ2, is not (English)

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based on heuristic

inferred from title

pulmonary tuberculosis

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based on heuristic

inferred from title

object named as

Graham A.W. Rook

7

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Alimuddin Zumla

object named as

Alimuddin Zumla

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1

object named as

Keertan Dheda

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author name string

Jung-Su Chang

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Jim F. Huggett

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Louise U. Kim

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Margaret A. Johnson

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publication date

May 2007

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87

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3

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237-241

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In vivo and in vitro studies of a novel cytokine, interleukin 4delta2, in pulmonary tuberculosis

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Increased production of interleukin 4 by CD4+ and CD8+ T cells from patients with tuberculosis is related to the presence of pulmonary cavities

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Healthy individuals that control a latent infection with Mycobacterium tuberculosis express high levels of Th1 cytokines and the IL-4 antagonist IL-4delta2.

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Structural and functional properties of IL-4delta2, an alternative splice variant of human IL-4.

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1 reference

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Altered IL-4 mRNA stability correlates with Th1 and Th2 bias and susceptibility to hypersensitivity pneumonitis in two inbred strains of mice.

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Suppression of the clinical and cytokine response to endotoxin by RWJ-67657, a p38 mitogen-activated protein-kinase inhibitor, in healthy human volunteers.

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10.1016/J.TUBE.2006.11.001

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