Tissue-type plasminogen activator as a therapeutic target in stroke (Q56336828)

Expert Opinion on Therapeutic Targets

Europe PubMed Central

title

Tissue-type plasminogen activator as a therapeutic target in stroke (English)

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1 reference

Iordanis Gravanis

1

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Stella E Tsirka

series ordinal

2

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language of work or name

English

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publication date

February 2008

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published in

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volume

12

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issue

2

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page(s)

159-70

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cites work

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Emergent use of anticoagulation for treatment of patients with ischemic stroke

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NXY-059 for acute ischemic stroke

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Tissue-type plasminogen activator is involved in the process of neuronal death induced by oxygen-glucose deprivation in culture

21 January 2018

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Tissue plasminogen activator protects hippocampal neurons from oxygen-glucose deprivation injury

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Modulation of zinc toxicity by tissue plasminogen activator.

21 January 2018

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Excitotoxin-induced neuronal degeneration and seizure are mediated by tissue plasminogen activator.

21 January 2018

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Neuronal cell death and tPA.

21 January 2018

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The proteolytic activity of tissue-plasminogen activator enhances NMDA receptor-mediated signaling.

21 January 2018

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Tissue plasminogen activator (tPA) increases neuronal damage after focal cerebral ischemia in wild-type and tPA-deficient mice

21 January 2018

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Recombinant tissue plasminogen activator reduces infarct size after reversible thread occlusion of middle cerebral artery in mice

21 January 2018

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Tissue plasminogen activator does not increase neuronal damage in rat models of global and focal ischemia.

21 January 2018

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Effects of recombinant tissue plasminogen activator after intraluminal thread occlusion in mice: role of hemodynamic alterations

21 January 2018

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Tissue plasminogen activator-induced ischemic injury is reversed by NMDA antagonist MK-801 in vivo

21 January 2018

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Essential role of endogenous tissue plasminogen activator through matrix metalloproteinase 9 induction and expression on heparin-produced cerebral hemorrhage after cerebral ischemia in mice

21 January 2018

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Neutralizing the neurotoxic effects of exogenous and endogenous tPA.

21 January 2018

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Magnetic resonance imaging indexes of therapeutic efficacy of recombinant tissue plasminogen activator treatment of rat at 1 and 4 hours after embolic stroke

21 January 2018

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Tissue-type plasminogen activator has paradoxical roles in focal cerebral ischemic injury by thrombotic middle cerebral artery occlusion with mild or severe photochemical damage in mice.

21 January 2018

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In vitro and in vivo effects of tPA and PAI-1 on blood vessel tone

21 January 2018

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LRP and alphavbeta3 mediate tPA activation of smooth muscle cells

21 January 2018

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Reduced cortical injury and edema in tissue plasminogen activator knockout mice after brain trauma.

21 January 2018

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The long-term effect of recombinant tissue-plasminogen-activator (rt-PA) on edema formation in a large-animal model of intracerebral hemorrhage

21 January 2018

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The role of endogenous versus exogenous tPA on edema formation in murine ICH.

21 January 2018

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Tissue-type plasminogen activator induces opening of the blood-brain barrier via the LDL receptor-related protein.

21 January 2018

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Extracellular proteolysis in brain injury and inflammation: role for plasminogen activators and matrix metalloproteinases

21 January 2018

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Lipoprotein receptor-mediated induction of matrix metalloproteinase by tissue plasminogen activator.

21 January 2018

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Involvement of matrix metalloproteinase in thrombolysis-associated hemorrhagic transformation after embolic focal ischemia in rats

21 January 2018

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Metalloproteinase inhibition reduces thrombolytic (tissue plasminogen activator)-induced hemorrhage after thromboembolic stroke.

21 January 2018

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Tissue plasminogen activator and NMDA receptor cleavage

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Ethanol-withdrawal seizures are controlled by tissue plasminogen activator via modulation of NR2B-containing NMDA receptors

21 January 2018

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Neurotoxic responses by microglia elicited by excitotoxic injury in the mouse hippocampus.

21 January 2018

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Neuronal death in the hippocampus is promoted by plasmin-catalyzed degradation of laminin.

21 January 2018

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Proteolytic activation of monocyte chemoattractant protein-1 by plasmin underlies excitotoxic neurodegeneration in mice.

21 January 2018

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Endocytic receptor LRP together with tPA and PAI-1 coordinates Mac-1-dependent macrophage migration

21 January 2018

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21 January 2018

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Reduction of excitotoxicity and associated leukocyte recruitment by a broad-spectrum matrix metalloproteinase inhibitor

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Microplasmin: a novel thrombolytic that improves behavioral outcome after embolic strokes in rabbits

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Purification and characterization of the plasminogen activator secreted by human melanoma cells in culture

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Activation of microglia reveals a non-proteolytic cytokine function for tissue plasminogen activator in the central nervous system

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Tissue type plasminogen activator amplifies hemoglobin-induced neurotoxicity in rat neuronal cultures

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Combined intravenous and intra-arterial r-TPA versus intra-arterial therapy of acute ischemic stroke: Emergency Management of Stroke (EMS) Bridging Trial

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Isolation and functional characterization of the heavy and light chains of human tissue-type plasminogen activator

1 reference

12 December 2020

Plasminogen deficiency causes severe thrombosis but is compatible with development and reproduction

1 reference

12 December 2020

The International Stroke Trial (IST): a randomised trial of aspirin, subcutaneous heparin, both, or neither among 19435 patients with acute ischaemic stroke. International Stroke Trial Collaborative Group

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12 December 2020

Emergency administration of abciximab for treatment of patients with acute ischemic stroke: results of an international phase III trial: Abciximab in Emergency Treatment of Stroke Trial (AbESTT-II)

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12 December 2020

10.1517/14728222.12.2.159

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DOI

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release_dhcp6wugfzfa3djwific4svhne

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/dhcp6wugfzfa3djwific4svhne

24 November 2022