Glycyl-tRNA synthetase 1 (Q5572591)

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mammalian protein found in Homo sapiens

GARS1
GlyRS
ap4A synthetase
diadenosine tetraphosphate synthetase
GARS
AP-4-A synthetase
Charcot-Marie-Tooth neuropathy, neuronal type, D
Charcot-Marie-Tooth neuropathy 2D
glycine--tRNA ligase
glycine-tRNA ligase

Language	Label	Description	Also known as
English	Glycyl-tRNA synthetase 1	mammalian protein found in Homo sapiens	GARS1 GlyRS ap4A synthetase diadenosine tetraphosphate synthetase GARS AP-4-A synthetase Charcot-Marie-Tooth neuropathy, neuronal type, D Charcot-Marie-Tooth neuropathy 2D glycine--tRNA ligase glycine-tRNA ligase

Statements

1 reference

13 November 2019

UniProt protein ID

Glycyl-tRNA synthetase

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P41250

Anticodon-binding domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P41250

S15/NS1, RNA-binding

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P41250

Aminoacyl-tRNA synthetase, class II (G/ P/ S/T), protein family

1 reference

based on heuristic

inferred from protein domain or family

Glycyl-tRNA synthetase-like core domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Aminoacyl tRNA synthetases, class II

1 reference

based on heuristic

inferred from protein domain or family

WHEP-TRS domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

ligase activity

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41250

determination method

protein dimerization activity

determination method

hydrolase activity

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41250

determination method

protein binding

determination method

identical protein binding

determination method

glycine-tRNA ligase activity

determination method

8 references

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P41250&geneProductId=UniProtKB:P41250

determination method

5 June 2018

Compound heterozygosity for loss-of-function GARS variants results in a multisystem developmental syndrome that includes severe growth retardation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P41250&geneProductId=UniProtKB:P41250

determination method

5 June 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P41250&geneProductId=UniProtKB:P41250

determination method

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P41250&geneProductId=UniProtKB:P41250

determination method

5 June 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P41250&geneProductId=UniProtKB:P41250

determination method

5 June 2018

Long-range structural effects of a Charcot-Marie-Tooth disease-causing mutation in human glycyl-tRNA synthetase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P41250&geneProductId=UniProtKB:P41250

determination method

5 June 2018

Crystal structures and biochemical analyses suggest a unique mechanism and role for human glycyl-tRNA synthetase in Ap4A homeostasis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P41250&geneProductId=UniProtKB:P41250

determination method

5 June 2018

Crystal structure of human wildtype and S581L-mutant glycyl-tRNA synthetase, an enzyme underlying distal spinal muscular atrophy

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P41250&geneProductId=UniProtKB:P41250

determination method

glycine-tRNA ligase activity

determination method

9 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P41250&geneProductId=UniProtKB:P41250

determination method

1 January 2018

Compound heterozygosity for loss-of-function GARS variants results in a multisystem developmental syndrome that includes severe growth retardation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P41250&geneProductId=UniProtKB:P41250

determination method

1 January 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P41250&geneProductId=UniProtKB:P41250

determination method

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P41250&geneProductId=UniProtKB:P41250

determination method

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P41250&geneProductId=UniProtKB:P41250

determination method

1 January 2018

Crystal structure of human wildtype and S581L-mutant glycyl-tRNA synthetase, an enzyme underlying distal spinal muscular atrophy

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P41250&geneProductId=UniProtKB:P41250

determination method

1 January 2018

Crystal structures and biochemical analyses suggest a unique mechanism and role for human glycyl-tRNA synthetase in Ap4A homeostasis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P41250&geneProductId=UniProtKB:P41250

determination method

1 January 2018

Long-range structural effects of a Charcot-Marie-Tooth disease-causing mutation in human glycyl-tRNA synthetase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P41250&geneProductId=UniProtKB:P41250

determination method

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P41250&geneProductId=UniProtKB:P41250

determination method

glycine-tRNA ligase activity

determination method

8 references

9 May 2019

Compound heterozygosity for loss-of-function GARS variants results in a multisystem developmental syndrome that includes severe growth retardation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41250

determination method

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41250

determination method

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41250

determination method

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41250

determination method

9 May 2019

Crystal structures and biochemical analyses suggest a unique mechanism and role for human glycyl-tRNA synthetase in Ap4A homeostasis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41250

determination method

9 May 2019

Crystal structure of human wildtype and S581L-mutant glycyl-tRNA synthetase, an enzyme underlying distal spinal muscular atrophy

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41250

determination method

9 May 2019

Long-range structural effects of a Charcot-Marie-Tooth disease-causing mutation in human glycyl-tRNA synthetase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41250

determination method

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41250

determination method

bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity

determination method

1 reference

9 May 2019

Crystal structures and biochemical analyses suggest a unique mechanism and role for human glycyl-tRNA synthetase in Ap4A homeostasis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41250

determination method

transferase activity

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41250

determination method

mitochondrial matrix

determination method

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41250

determination method

cell projection

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41250

determination method

secretory granule

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41250

determination method

extracellular exosome

determination method

4 references

31 October 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P41250&geneProductId=UniProtKB:P41250

determination method

31 October 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P41250&geneProductId=UniProtKB:P41250

determination method

31 October 2017

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P41250&geneProductId=UniProtKB:P41250

determination method

31 October 2017

Proteomic analysis of podocyte exosome-enriched fraction from normal human urine

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P41250&geneProductId=UniProtKB:P41250

determination method

extracellular region

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41250

determination method

determination method

3 references

5 June 2018

Primary structure and functional expression of human Glycyl-tRNA synthetase, an autoantigen in myositis

http://www.ebi.ac.uk/QuickGO/annotations?protein=P41250&geneProductId=UniProtKB:P41250

determination method

5 June 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P41250&geneProductId=UniProtKB:P41250

determination method

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P41250&geneProductId=UniProtKB:P41250

determination method

determination method

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41250

determination method

extracellular exosome

determination method

determination method

4 references

9 May 2019

Primary structure and functional expression of human Glycyl-tRNA synthetase, an autoantigen in myositis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41250

determination method

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41250

determination method

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41250

determination method

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41250

determination method

biological process

diadenosine tetraphosphate biosynthetic process

determination method

1 reference

9 May 2019

Crystal structures and biochemical analyses suggest a unique mechanism and role for human glycyl-tRNA synthetase in Ap4A homeostasis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41250

determination method

protein biosynthesis

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41250

determination method

mitochondrial glycyl-tRNA aminoacylation

determination method

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41250

determination method

tRNA aminoacylation for protein translation

determination method

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41250

determination method

9 May 2019

Compound heterozygosity for loss-of-function GARS variants results in a multisystem developmental syndrome that includes severe growth retardation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41250

determination method

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41250

determination method

glycyl-tRNA aminoacylation

determination method

Gene Atlas image

PBB GE GARS 208693 s at fs.png
732 × 530; 11 KB

0 references

http://purl.uniprot.org/uniprot/P41250

1 reference

Identifiers.org

Glycyl-tRNA synthetase-like core domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P41250

Anticodon-binding

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P41250

WHEP-TRS domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P41250

Aminoacyl-tRNA synthetase, class II (G/ P/ S/T)

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P41250

Aminoacyl-tRNA synthetase, class II domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P41250

Identifiers

MeSH descriptor ID

subject named as

Glycine-tRNA Ligase

0 references

D08.811.464.263.200.350

0 references

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000373918

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000373918

ENSP00000392677

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000392677

ENSP00000415447

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000415447

ENSP00000485931

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000485931

PDB structure ID

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

based on heuristic

inferred by common MeSH mappings on source and on Wikidata

24 May 2023

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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