Reduced latency but no increased brain tumor penetrance in mice with astrocyte specific expression of a human p53 mutant. (Q55474891)

12 July 2018

title

Reduced latency but no increased brain tumor penetrance in mice with astrocyte specific expression of a human p53 mutant. (English)

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12 July 2018

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9

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author name string

Klein MA

1

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12 July 2018

Rüedi D

2

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Nozaki M

3

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Dell EW

4

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12 July 2018

Diserens AC

5

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12 July 2018

Seelentag W

6

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12 July 2018

Janzer RC

7

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Aguzzi A

8

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language of work or name

English

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publication date

1 November 2000

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12 July 2018

published in

Oncogene

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12 July 2018

volume

19

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12 July 2018

issue

47

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12 July 2018

page(s)

5329-5337

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12 July 2018

https://scigraph.springernature.com/pub.10.1038/sj.onc.1203941

exact match

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Cancer phenotype correlates with constitutional TP53 genotype in families with the Li-Fraumeni syndrome.

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Functional analyses of a unique p53 germline mutant (Y236delta) associated with a familial brain tumor syndrome

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Transcriptional activation by p53 correlates with suppression of growth but not transformation.

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Induction of neurogenic tumors in C3HeB-FeJ mice by nitrosourea derivatives: observations by light microscopy, tissue culture, and electron microscopy.

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Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

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Astrocytomas in an inbred mouse strain

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A mutant p53 that discriminates between p53-responsive genes cannot induce apoptosis

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p53 gene mutation and ink4a-arf deletion appear to be two mutually exclusive events in human glioblastoma.

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An oncogenic form of p53 confers a dominant, gain-of-function phenotype that disrupts spindle checkpoint control

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Reduction of p53 gene dosage does not increase initiation or promotion but enhances malignant progression of chemically induced skin tumors.

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High incidence of lung, bone, and lymphoid tumors in transgenic mice overexpressing mutant alleles of the p53 oncogene

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High metastatic potential in mice inheriting a targeted p53 missense mutation

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No complementation between TP53 or RB-1 and v-src in astrocytomas of GFAP-v-src transgenic mice.

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Somatic deletion mapping on chromosome 10 and sequence analysis of PTEN/MMAC1 point to the 10q25-26 region as the primary target in low-grade and high-grade gliomas.

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DMBT1, a new member of the SRCR superfamily, on chromosome 10q25.3-26.1 is deleted in malignant brain tumours

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c-Src phosphorylates epidermal growth factor receptor on tyrosine 845.

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Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers

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Genetic background alters the spectrum of tumors that develop in p53-deficient mice

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7 January 2021

Familial Brain Tumour Syndrome Associated with a p53 Germline Deletion of Codon 236

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7 January 2021

The amino acid sequence of murine p53 determined from a c-DNA clone

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7 January 2021

Tight DNA binding and oligomerization are dispensable for the ability of p53 to transactivate target genes and suppress transformation.

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7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1203941

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12 July 2018

Dimensions Publication ID

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12 July 2018