Downregulation of GLS2 in glioblastoma cells is related to DNA hypermethylation but not to the p53 status. (Q55459904)

http://europepmc.org/abstract/MED/26258493

12 July 2018

title

Downregulation of GLS2 in glioblastoma cells is related to DNA hypermethylation but not to the p53 status. (English)

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http://europepmc.org/abstract/MED/26258493

12 July 2018

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4

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31 May 2020

Jan Albrecht

series ordinal

5

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31 May 2020

1

Monika Szeliga

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31 May 2020

author name string

Małgorzata Bogacińska-Karaś

series ordinal

2

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31 May 2020

Katarzyna Kuźmicz

series ordinal

3

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31 May 2020

publication date

10 August 2015

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http://europepmc.org/abstract/MED/26258493

12 July 2018

published in

Molecular Carcinogenesis

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31 May 2020

volume

55

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31 May 2020

issue

9

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31 May 2020

page(s)

1309-1316

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Mammalian glutaminase isozymes in brain

31 May 2020

cites work

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Epigenetic silencing of glutaminase 2 in human liver and colon cancers

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Glutaminase 2, a novel p53 target gene regulating energy metabolism and antioxidant function

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Transfection with liver-type glutaminase cDNA alters gene expression and reduces survival, migration and proliferation of T98G glioma cells.

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Transfection of a human glioblastoma cell line with liver-type glutaminase (LGA) down-regulates the expression of DNA-repair gene MGMT and sensitizes the cells to alkylating agents

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Mammalian glutaminase Gls2 gene encodes two functional alternative transcripts by a surrogate promoter usage mechanism

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Glutaminase 2 negatively regulates the PI3K/AKT signaling and shows tumor suppression activity in human hepatocellular carcinoma

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Impact of mutant p53 functional properties on TP53 mutation patterns and tumor phenotype: lessons from recent developments in the IARC TP53 database

21 January 2018

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Both GLS silencing and GLS2 overexpression synergize with oxidative stress against proliferation of glioma cells.

21 January 2018

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Opposing roles of glutaminase isoforms in determining glioblastoma cell phenotype.

21 January 2018

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c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism

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Inhibition of glutaminase expression by antisense mRNA decreases growth and tumourigenicity of tumour cells

21 January 2018

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Pyruvate carboxylase is required for glutamine-independent growth of tumor cells

21 January 2018

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ErbB2 activation upregulates glutaminase 1 expression which promotes breast cancer cell proliferation

21 January 2018

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Inhibition of glutaminase preferentially slows growth of glioma cells with mutant IDH1.

21 January 2018

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Targeting mitochondrial glutaminase activity inhibits oncogenic transformation

21 January 2018

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Design, synthesis, and pharmacological evaluation of bis-2-(5-phenylacetamido-1,2,4-thiadiazol-2-yl)ethyl sulfide 3 (BPTES) analogs as glutaminase inhibitors.

21 January 2018

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Discovery of selective inhibitors of Glutaminase-2, which inhibit mTORC1, activate autophagy and inhibit proliferation in cancer cells

21 January 2018

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Knock-down of glutaminase 2 expression decreases glutathione, NADH, and sensitizes cervical cancer to ionizing radiation

21 January 2018

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Promoter hypermethylation of the RB1 gene in glioblastomas.

21 January 2018

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PTEN methylation and expression in glioblastomas.

21 January 2018

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TP53 promoter methylation in human gliomas

21 January 2018

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MGMT gene silencing and benefit from temozolomide in glioblastoma

21 January 2018

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MGMT in primary and recurrent human glioblastomas after radiation and chemotherapy and comparison with p53 status and clinical outcome.

21 January 2018

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Comparable frequency of BRCA1, BRCA2 and TP53 germline mutations in a multi-ethnic Asian cohort suggests TP53 screening should be offered together with BRCA1/2 screening to early-onset breast cancer patients.

21 January 2018

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Mutant p53: one name, many proteins

21 January 2018

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p63 regulates glutaminase 2 expression.

21 January 2018

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GLS2 is transcriptionally regulated by p73 and contributes to neuronal differentiation

21 January 2018

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Retracted: MiR-145 Regulates Epithelial to Mesenchymal Transition of Breast Cancer Cells by Targeting Oct4

21 January 2018

1 reference

12 January 2024

https://opencitations.net/index/api/v1/citations/10.1371/JOURNAL.PONE.0045965

Identifiers

DOI

10.1002/MC.22372

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26258493%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

1 reference