Phase 1 trial, pharmacokinetics, and pharmacodynamics of dasatinib combined with crizotinib in children with recurrent or progressive high-grade and diffuse intrinsic pontine glioma. (Q55456561)

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English	Phase 1 trial, pharmacokinetics, and pharmacodynamics of dasatinib combined with crizotinib in children with recurrent or progressive high-grade and diffuse intrinsic pontine glioma.	scientific article

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scholarly article

1 reference

Europe PubMed Central

11 July 2018

http://europepmc.org/abstract/MED/29512900

Phase 1 trial, pharmacokinetics, and pharmacodynamics of dasatinib combined with crizotinib in children with recurrent or progressive high-grade and diffuse intrinsic pontine glioma. (English)

1 reference

Europe PubMed Central

11 July 2018

http://europepmc.org/abstract/MED/29512900

diffuse midline glioma

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phase I clinical trial

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1 reference

based on heuristic

inferred from title

dasatinib monohydrate

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based on heuristic

inferred from title

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based on heuristic

inferred from title

Alberto Broniscer

1

1 reference

Europe PubMed Central

11 July 2018

http://europepmc.org/abstract/MED/29512900

Ruth G. Tatevossian

object named as

Ruth G Tatevossian

9

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Belinda Mandrell

object named as

Belinda Mandrell

3

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author name string

Sujuan Jia

2

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Europe PubMed Central

11 July 2018

http://europepmc.org/abstract/MED/29512900

Dima Hamideh

4

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Europe PubMed Central

11 July 2018

http://europepmc.org/abstract/MED/29512900

Jie Huang

5

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Europe PubMed Central

11 July 2018

http://europepmc.org/abstract/MED/29512900

Arzu Onar-Thomas

6

1 reference

Europe PubMed Central

11 July 2018

http://europepmc.org/abstract/MED/29512900

Amar Gajjar

7

1 reference

Europe PubMed Central

11 July 2018

http://europepmc.org/abstract/MED/29512900

Susana C Raimondi

8

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Europe PubMed Central

11 July 2018

http://europepmc.org/abstract/MED/29512900

Clinton F Stewart

10

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Europe PubMed Central

11 July 2018

http://europepmc.org/abstract/MED/29512900

publication date

7 March 2018

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Europe PubMed Central

11 July 2018

http://europepmc.org/abstract/MED/29512900

Pediatric Blood Cancer

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Europe PubMed Central

11 July 2018

http://europepmc.org/abstract/MED/29512900

65

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Europe PubMed Central

11 July 2018

http://europepmc.org/abstract/MED/29512900

e27035

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Europe PubMed Central

11 July 2018

http://europepmc.org/abstract/MED/29512900

7

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Europe PubMed Central

11 July 2018

http://europepmc.org/abstract/MED/29512900

CBTRUS Statistical Report: Primary Brain and Other Central Nervous System Tumors Diagnosed in the United States in 2009-2013.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5980705

7 September 2018

First-dose and steady-state pharmacokinetics of orally administered crizotinib in children with solid tumors: a report on ADVL0912 from the Children's Oncology Group Phase 1/Pilot Consortium

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5980705

7 September 2018

Recurrent MET fusion genes represent a drug target in pediatric glioblastoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5980705

7 September 2018

Characterizing and targeting PDGFRA alterations in pediatric high-grade glioma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5980705

7 September 2018

Functionally defined therapeutic targets in diffuse intrinsic pontine glioma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5980705

7 September 2018

CSF Concentration of Crizotinib in Two ALK-Positive Non-Small-Cell Lung Cancer Patients with CNS Metastases Deriving Clinical Benefit from Treatment.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5980705

7 September 2018

Integrated analysis of pediatric glioblastoma reveals a subset of biologically favorable tumors with associated molecular prognostic markers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5980705

7 September 2018

Preclinical evaluation of dasatinib alone and in combination with cabozantinib for the treatment of diffuse intrinsic pontine glioma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5980705

7 September 2018

Use of human embryonic stem cells to model pediatric gliomas with H3.3K27M histone mutation

1 reference

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7 September 2018

Targeting MET for glioma therapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5980705

7 September 2018

Clinical, radiological, histological and molecular characteristics of paediatric epithelioid glioblastoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5980705

7 September 2018

Novel oncogenic PDGFRA mutations in pediatric high-grade gliomas

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5980705

7 September 2018

Safety and activity of crizotinib for paediatric patients with refractory solid tumours or anaplastic large-cell lymphoma: a Children's Oncology Group phase 1 consortium study.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5980705

7 September 2018

Phase I trial, pharmacokinetics, and pharmacodynamics of vandetanib and dasatinib in children with newly diagnosed diffuse intrinsic pontine glioma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5980705

7 September 2018

Hepatocyte growth factor sensitizes brain tumors to c-MET kinase inhibition

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5980705

7 September 2018

Hotspot mutations in H3F3A and IDH1 define distinct epigenetic and biological subgroups of glioblastoma.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5980705

7 September 2018

Somatic histone H3 alterations in pediatric diffuse intrinsic pontine gliomas and non-brainstem glioblastomas

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5980705

7 September 2018

Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5980705

7 September 2018

Rapid radiographic and clinical improvement after treatment of a MET-amplified recurrent glioblastoma with a mesenchymal-epithelial transition inhibitor

1 reference

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7 September 2018

Genome-wide analyses identify recurrent amplifications of receptor tyrosine kinases and cell-cycle regulatory genes in diffuse intrinsic pontine glioma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5980705

7 September 2018

Pediatric phase I trial and pharmacokinetic study of dasatinib: a report from the children's oncology group phase I consortium

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5980705

7 September 2018

Preclinical evaluation of radiation and perifosine in a genetically and histologically accurate model of brainstem glioma

1 reference

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7 September 2018

P-glycoprotein and breast cancer resistance protein influence brain distribution of dasatinib

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5980705

7 September 2018

The PedsQL Brain Tumor Module: initial reliability and validity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5980705

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Platelet-derived growth factor (PDGF) and glial tumorigenesis

1 reference

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The PedsQL in pediatric cancer: reliability and validity of the Pediatric Quality of Life Inventory Generic Core Scales, Multidimensional Fatigue Scale, and Cancer Module.

1 reference

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7 September 2018

Identifiers

10.1002/PBC.27035

1 reference

Europe PubMed Central

11 July 2018

http://europepmc.org/abstract/MED/29512900

0 references

1 reference

Europe PubMed Central

11 July 2018

http://europepmc.org/abstract/MED/29512900

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