Growth factor receptor bound protein 10 (Q5514411)

mammalian protein found in Homo sapiens

maternally expressed gene 1
insulin receptor-binding protein Grb-IR
growth factor receptor-bound protein 10
GRB10
GRB10 adaptor protein
GRB10 adapter protein

Language	Label	Description	Also known as
English	Growth factor receptor bound protein 10	mammalian protein found in Homo sapiens	maternally expressed gene 1 insulin receptor-binding protein Grb-IR growth factor receptor-bound protein 10 GRB10 GRB10 adaptor protein GRB10 adapter protein

Statements

1 reference

13 November 2019

1 reference

13 November 2019

1 reference

13 November 2019

8 references

9 May 2019

Grb10 prevents Nedd4-mediated vascular endothelial growth factor receptor-2 degradation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13322

9 May 2019

Critical involvement of RQCD1 in the EGFR-Akt pathway in mammary carcinogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13322

9 May 2019

Phosphorylation of grb10 regulates its interaction with 14-3-3

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13322

9 May 2019

GIGYF2 is present in endosomal compartments in the mammalian brains and enhances IGF-1-induced ERK1/2 activation

GOA

curator

Parkinsons Disease Gene Ontology Initiative

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13322

9 May 2019

Ligand activation of ELK receptor tyrosine kinase promotes its association with Grb10 and Grb2 in vascular endothelial cells

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13322

9 May 2019

Phospho-tyrosine dependent protein-protein interaction network

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13322

9 May 2019

FLT3 signals via the adapter protein Grb10 and overexpression of Grb10 leads to aberrant cell proliferation in acute myeloid leukemia

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13322

9 May 2019

Grb10 interacts differentially with the insulin receptor, insulin-like growth factor I receptor, and epidermal growth factor receptor via the Grb10 Src homology 2 (SH2) domain and a second novel domain located between the pleckstrin homology [...]

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13322

determination method

IPI

identical protein binding

1 reference

5 June 2018

Structural and functional studies of the Ras-associating and pleckstrin-homology domains of Grb10 and Grb14

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13322&geneProductId=UniProtKB:Q13322

determination method

IPI

insulin receptor binding

3 references

9 May 2019

Distinct Grb10 domain requirements for effects on glucose uptake and insulin signaling

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13322

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13322

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13322

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13322

1 reference

9 May 2019

Human GRB-IRbeta/GRB10. Splice variants of an insulin and growth factor receptor-binding protein with PH and SH2 domains

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13322

determination method

TAS

protein-containing complex

1 reference

9 May 2019

Critical involvement of RQCD1 in the EGFR-Akt pathway in mammary carcinogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13322

1 reference

5 June 2018

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13322&geneProductId=UniProtKB:Q13322

determination method

ISS

positive regulation of vascular endothelial growth factor receptor signaling pathway

1 reference

9 May 2019

Grb10 prevents Nedd4-mediated vascular endothelial growth factor receptor-2 degradation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13322

determination method

IDA

insulin-like growth factor receptor signaling pathway

1 reference

1 January 2018

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13322

determination method

IEA

negative regulation of phosphorylation

1 reference

1 January 2018

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13322

determination method

IEA

positive regulation of phosphorylation

1 reference

5 June 2018

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13322&geneProductId=UniProtKB:Q13322

determination method

ISS

negative regulation of glycogen biosynthetic process

1 reference

5 June 2018

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13322&geneProductId=UniProtKB:Q13322

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13322

determination method

IEA

insulin receptor signaling pathway

1 reference

5 June 2018

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13322&geneProductId=UniProtKB:Q13322

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13322

determination method

TAS

negative regulation of Wnt signaling pathway

1 reference

8 April 2019

GRB10 binds to LRP6, the Wnt co-receptor and inhibits canonical Wnt signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13322

determination method

IDA

negative regulation of glucose import

1 reference

9 May 2019

Distinct Grb10 domain requirements for effects on glucose uptake and insulin signaling

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13322

determination method

ISS

positive regulation of cold-induced thermogenesis

1 reference

9 May 2019

Grb10 promotes lipolysis and thermogenesis by phosphorylation-dependent feedback inhibition of mTORC1.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13322

determination method

ISS

insulin receptor signaling pathway

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13322

determination method

IBA

negative regulation of insulin receptor signaling pathway

3 references

9 May 2019

Distinct Grb10 domain requirements for effects on glucose uptake and insulin signaling

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13322

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13322

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13322

determination method

IBA

Gene Atlas image

PBB GE GRB10 209409 at fs.png
732 × 530; 12 KB

0 references

exact match

http://purl.uniprot.org/uniprot/Q13322

1 reference

stated in

Identifiers.org

Identifiers

MeSH descriptor ID

D051383

subject named as

GRB10 Adaptor Protein

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13 November 2019

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9 August 2016

language of work or name

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9 August 2016

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inferred by common MeSH mappings on source and on Wikidata

stated in

UMLS 2023

retrieved

25 May 2023

Growth factor receptor bound protein 10 (Q5514411)

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Growth factor receptor bound protein 10 (Q5514411)

Statements

Identifiers

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

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