Free fatty acid receptor 2 (Q5500223)

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O15552

GPCR, rhodopsin-like, 7TM, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

1 reference

13 November 2019

G protein-coupled receptor activity

6 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15552

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15552

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15552

8 April 2019

Conserved polar residues in transmembrane domains V, VI, and VII of free fatty acid receptor 2 and free fatty acid receptor 3 are required for the binding and function of short chain fatty acids

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15552

8 April 2019

The Orphan G protein-coupled receptors GPR41 and GPR43 are activated by propionate and other short chain carboxylic acids

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15552

8 April 2019

Defining the molecular basis for the first potent and selective orthosteric agonists of the FFA2 free fatty acid receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15552

signal transducer activity

1 reference

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=O15552&geneProductId=UniProtKB:O15552

1 reference

8 April 2019

Secreted M-ficolin anchors onto monocyte transmembrane G protein-coupled receptor 43 and cross talks with plasma C-reactive protein to mediate immune signaling and regulate host defense

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15552

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15552

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15552

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15552

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15552

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15552

8 April 2019

Conserved polar residues in transmembrane domains V, VI, and VII of free fatty acid receptor 2 and free fatty acid receptor 3 are required for the binding and function of short chain fatty acids

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15552

8 April 2019

Secreted M-ficolin anchors onto monocyte transmembrane G protein-coupled receptor 43 and cross talks with plasma C-reactive protein to mediate immune signaling and regulate host defense

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15552

integral component of plasma membrane

1 reference

8 April 2019

A cluster of four novel human G protein-coupled receptor genes occurring in close proximity to CD22 gene on chromosome 19q13.1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15552

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15552

TAS

biological process

immune system process

1 reference

8 April 2019

cellular response to fatty acid

IEA

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15552

8 April 2019

Conserved polar residues in transmembrane domains V, VI, and VII of free fatty acid receptor 2 and free fatty acid receptor 3 are required for the binding and function of short chain fatty acids

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15552

8 April 2019

The Orphan G protein-coupled receptors GPR41 and GPR43 are activated by propionate and other short chain carboxylic acids

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15552

8 April 2019

Defining the molecular basis for the first potent and selective orthosteric agonists of the FFA2 free fatty acid receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15552

cell surface pattern recognition receptor signaling pathway

1 reference

8 April 2019

Secreted M-ficolin anchors onto monocyte transmembrane G protein-coupled receptor 43 and cross talks with plasma C-reactive protein to mediate immune signaling and regulate host defense

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15552

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15552

IMP

inflammatory response

1 reference

8 April 2019

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15552

G protein-coupled receptor signaling pathway

IEA

7 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15552

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15552

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15552

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15552

8 April 2019

Conserved polar residues in transmembrane domains V, VI, and VII of free fatty acid receptor 2 and free fatty acid receptor 3 are required for the binding and function of short chain fatty acids

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15552

8 April 2019

The Orphan G protein-coupled receptors GPR41 and GPR43 are activated by propionate and other short chain carboxylic acids

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15552

8 April 2019

Defining the molecular basis for the first potent and selective orthosteric agonists of the FFA2 free fatty acid receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15552

physically interacts with

1 reference

1059

English

retrieved

17 August 2016

2-methylpropanoic acid

has use

agonist

1 reference

1060

(E)-2,3-dimethylacrylic acid

English

retrieved

17 August 2016

has use

agonist

1 reference

6499

17 August 2016

1 reference

1061

17 August 2016

1 reference

1062

GPCR, rhodopsin-like, 7TM

English

retrieved

17 August 2016

Gene Atlas image

PBB GE FFAR2 221345 at fs.png
732 × 530; 10 KB

0 references

has part(s)

1 reference

InterPro Release 71.0