Pancreatic cancer therapy with combined mesothelin-redirected chimeric antigen receptor T cells and cytokine-armed oncolytic adenoviruses. (Q54965295)

14 June 2018

title

Pancreatic cancer therapy with combined mesothelin-redirected chimeric antigen receptor T cells and cytokine-armed oncolytic adenoviruses. (English)

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14 June 2018

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Akseli Hemminki

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15

Carl H June

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14 June 2018

author name string

Keisuke Watanabe

1

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14 June 2018

Yanping Luo

2

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14 June 2018

Tong Da

3

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Sonia Guedan

4

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Marco Ruella

5

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John Scholler

6

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Brian Keith

7

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Regina M Young

8

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Boris Engels

9

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Suvi Sorsa

10

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14 June 2018

Mikko Siurala

11

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14 June 2018

Riikka Havunen

12

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14 June 2018

Siri Tähtinen

13

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publication date

5 April 2018

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14 June 2018

published in

JCI insight

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14 June 2018

volume

3

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14 June 2018

issue

7

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14 June 2018

Adenovirotherapy Delivering Cytokine and Checkpoint Inhibitor Augments CAR T Cells against Metastatic Head and Neck Cancer

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Modulation of the Intratumoral Immune Landscape by Oncolytic Herpes Simplex Virus Virotherapy

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Oncolytic Adenoviruses Armed with Tumor Necrosis Factor Alpha and Interleukin-2 Enable Successful Adoptive Cell Therapy

14 June 2018

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Armed Oncolytic Adenovirus-Expressing PD-L1 Mini-Body Enhances Antitumor Effects of Chimeric Antigen Receptor T Cells in Solid Tumors

14 June 2018

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The prognostic value of tumor-infiltrating T lymphocytes in ovarian cancer

14 June 2018

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14 June 2018

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T Cells Engineered against a Native Antigen Can Surmount Immunologic and Physical Barriers to Treat Pancreatic Ductal Adenocarcinoma

14 June 2018

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Mesothelin-Targeted CARs: Driving T Cells to Solid Tumors

14 June 2018

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Favorable alteration of tumor microenvironment by immunomodulatory cytokines for efficient T-cell therapy in solid tumors

14 June 2018

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Talimogene Laherparepvec Improves Durable Response Rate in Patients With Advanced Melanoma

14 June 2018

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Adenovirus Improves the Efficacy of Adoptive T-cell Therapy by Recruiting Immune Cells to and Promoting Their Activity at the Tumor

14 June 2018

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Application of xCELLigence RTCA Biosensor Technology for Revealing the Profile and Window of Drug Responsiveness in Real Time.

14 June 2018

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Chemotherapy-refractory diffuse large B-cell lymphoma and indolent B-cell malignancies can be effectively treated with autologous T cells expressing an anti-CD19 chimeric antigen receptor

14 June 2018

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Armed oncolytic virus enhances immune functions of chimeric antigen receptor-modified T cells in solid tumors

14 June 2018

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Going viral with cancer immunotherapy

14 June 2018

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Multifactorial T-cell hypofunction that is reversible can limit the efficacy of chimeric antigen receptor-transduced human T cells in solid tumors

14 June 2018

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Regimen-specific effects of RNA-modified chimeric antigen receptor T cells in mice with advanced leukemia

14 June 2018

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Characteristics of chemokine signatures elicited by EGF and TNF in ovarian cancer cells

14 June 2018

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A phase I clinical trial of Ad5/3-Δ24, a novel serotype-chimeric, infectivity-enhanced, conditionally-replicative adenovirus (CRAd), in patients with recurrent ovarian cancer

14 June 2018

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Chimeric antigen receptor-modified T cells for acute lymphoid leukemia

14 June 2018

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Prognostic significance of tumor-infiltrating lymphocytes for patients with colorectal cancer

14 June 2018

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Desmoglein 2 is a receptor for adenovirus serotypes 3, 7, 11 and 14.

14 June 2018

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14 June 2018

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14 June 2018

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Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice

14 June 2018

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Antibody phage display technology and its applications.

14 June 2018

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TNF alpha induces expression of the chemoattractant cytokine RANTES in cultured mouse mesangial cells

14 June 2018

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14 June 2018

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Chimeric antigen receptor-modified T cells for the treatment of solid tumors: Defining the challenges and next steps

14 June 2018

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Pancreatic ductal adenocarcinoma: a review of immunologic aspects

16 June 2018

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Control of large, established tumor xenografts with genetically retargeted human T cells containing CD28 and CD137 domains.

16 June 2018

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16 June 2018

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Identification of unique neoantigen qualities in long-term survivors of pancreatic cancer.

16 June 2018

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Cancer immunotherapy with recombinant poliovirus induces IFN-dominant activation of dendritic cells and tumor antigen-specific CTLs.

13 August 2018

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A single dose of peripherally infused EGFRvIII-directed CAR T cells mediates antigen loss and induces adaptive resistance in patients with recurrent glioblastoma.

13 August 2018

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Phase 1 Results of ZUMA-1: A Multicenter Study of KTE-C19 Anti-CD19 CAR T Cell Therapy in Refractory Aggressive Lymphoma

13 August 2018

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Enhanced therapeutic efficacy for ovarian cancer with a serotype 3 receptor-targeted oncolytic adenovirus

13 August 2018

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MUC1-specific CTLs are non-functional within a pancreatic tumor microenvironment

13 August 2018

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Pancreatic Adenocarcinoma

13 August 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5928866

Prevalence of regulatory T cells is increased in peripheral blood and tumor microenvironment of patients with pancreas or breast adenocarcinoma

13 August 2018

1 reference

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TNF-alpha is a potent inducer for IFN-inducible protein-10 in hepatocytes and unaffected by GM-CSF in vivo, in contrast to IL-1beta and IFN-gamma

2 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/29618658

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Host-derived MCP-1 and MIP-1α regulate protective anti-tumor immunity to localized and metastatic B16 melanoma

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/29618658

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1172/JCI.INSIGHT.99573

1 reference

14 June 2018

PMCID

5928866

1 reference

14 June 2018

PubMed ID

29618658

1 reference

14 June 2018