Systems biology-embedded target validation: improving efficacy in drug discovery. (Q54627325)

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title

Systems biology-embedded target validation: improving efficacy in drug discovery. (English)

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4

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Walter Kolch

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Drieke Vandamme

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object named as

Drieke Vandamme

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author name string

Benedikt A Minke

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William Fitzmaurice

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publication date

8 November 2013

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Wiley interdisciplinary reviews. Systems biology and medicine

published in

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volume

6

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issue

1

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page(s)

1-11

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Priorities for improving drug research, development and regulation.

cites work

1 reference

Lessons from 60 years of pharmaceutical innovation

21 January 2018

1 reference

Trends in risks associated with new drug development: success rates for investigational drugs

21 January 2018

1 reference

Trial watch: Phase II failures: 2008-2010.

21 January 2018

1 reference

Phase III and submission failures: 2007–2010

21 January 2018

1 reference

Aspirin inhibits colon cancer cell and tumor growth and downregulates specificity protein (Sp) transcription factors

21 January 2018

1 reference

Fulfilling the promise: drug discovery in the post-genomic era.

21 January 2018

1 reference

Drug discovery of the future: the implications of the human genome project

21 January 2018

1 reference

Trends in the exploitation of novel drug targets

21 January 2018

1 reference

The limits of reductionism in medicine: could systems biology offer an alternative?

21 January 2018

1 reference

Emerging real-time technologies in molecular medicine and the evolution of integrated 'pharmacomics' approaches to personalized medicine and drug discovery

21 January 2018

1 reference

Genome-wide association studies: progress and potential for drug discovery and development

21 January 2018

1 reference

Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia

21 January 2018

1 reference

Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib

21 January 2018

1 reference

Protein tyrosine phosphatases in the human genome

21 January 2018

1 reference

Protein tyrosine phosphatases as drug targets: strategies and challenges of inhibitor development

21 January 2018

1 reference

Signalling by protein phosphatases and drug development: a systems-centred view.

21 January 2018

1 reference

A novel, evolutionarily conserved protein phosphatase complex involved in cisplatin sensitivity

21 January 2018

1 reference

A systems biological approach suggests that transcriptional feedback regulation by dual-specificity phosphatase 6 shapes extracellular signal-related kinase activity in RAS-transformed fibroblasts

21 January 2018

1 reference

Principles behind the multifarious control of signal transduction

21 January 2018

1 reference

Proteins, drug targets and the mechanisms they control: the simple truth about complex networks

21 January 2018

1 reference

Network pharmacology: the next paradigm in drug discovery

21 January 2018

1 reference

Signalling ballet in space and time

21 January 2018

1 reference

Network-based classification of breast cancer metastasis

21 January 2018

1 reference

A systems biology approach identifies molecular networks defining skeletal muscle abnormalities in chronic obstructive pulmonary disease

21 January 2018

1 reference

Network analysis identifies a putative role for the PPAR and type 1 interferon pathways in glucocorticoid actions in asthmatics

21 January 2018

1 reference

Application of 'omics technologies to biomarker discovery in inflammatory lung diseases

21 January 2018

1 reference

The evolution of protein kinase inhibitors from antagonists to agonists of cellular signaling

21 January 2018

1 reference

Global effects of kinase inhibitors on signaling networks revealed by quantitative phosphoproteomics

21 January 2018

1 reference

Chemical proteomic profiles of the BCR-ABL inhibitors imatinib, nilotinib, and dasatinib reveal novel kinase and nonkinase targets

21 January 2018

1 reference

A computational model to predict the effects of class I anti-arrhythmic drugs on ventricular rhythms

21 January 2018

1 reference

Cancer chronotherapeutics: experimental, theoretical, and clinical aspects

21 January 2018

1 reference

A combined experimental and mathematical approach for molecular-based optimization of irinotecan circadian delivery

21 January 2018

1 reference

Prediction of survival by neutropenia according to delivery schedule of oxaliplatin-5-Fluorouracil-leucovorin for metastatic colorectal cancer in a randomized international trial (EORTC 05963).

21 January 2018

1 reference

Identifying mechanisms of chronotolerance and chronoefficacy for the anticancer drugs 5-fluorouracil and oxaliplatin by computational modeling

21 January 2018

1 reference

Application of cardiac electrophysiology simulations to pro-arrhythmic safety testing.

21 January 2018

1 reference

Drug-target network in myocardial infarction reveals multiple side effects of unrelated drugs

21 January 2018

1 reference

21 January 2018

1 reference

Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

21 January 2018

1 reference

Finding novel pharmaceuticals in the systems biology era using multiple effective drug targets, phenotypic screening and knowledge of transporters: where drug discovery went wrong and how to fix it.

21 January 2018

1 reference

What makes a good drug target?

21 January 2018

1 reference

The two "hit" and multiple "hit" theories of carcinogenesis

21 January 2018

1 reference

Principles for the buffering of genetic variation

21 January 2018

1 reference

Can we rationally design promiscuous drugs?

21 January 2018

1 reference

Rational approaches to targeted polypharmacology: creating and navigating protein-ligand interaction networks

21 January 2018

1 reference

Chemical genetic discovery of targets and anti-targets for cancer polypharmacology

21 January 2018

1 reference

Comparison of a standard regimen (CHOP) with three intensive chemotherapy regimens for advanced non-Hodgkin's lymphoma

21 January 2018

1 reference

Rational design of cancer-drug combinations

21 January 2018

1 reference

Systems approaches and algorithms for discovery of combinatorial therapies

21 January 2018

1 reference

Improved survival with MEK inhibition in BRAF-mutated melanoma

21 January 2018

1 reference

Sequential application of anticancer drugs enhances cell death by rewiring apoptotic signaling networks.

21 January 2018

1 reference

Drug inhibition profile prediction for NFκB pathway in multiple myeloma

21 January 2018

1 reference

The mammalian MAPK/ERK pathway exhibits properties of a negative feedback amplifier

21 January 2018

1 reference

Systems pharmacology, pharmacogenetics, and clinical trial design in network medicine

21 January 2018

1 reference

Dose-response modeling in reproductive toxicology in the systems biology era.

21 January 2018

1 reference

Pharmacokinetics/Pharmacodynamics and the stages of drug development: role of modeling and simulation

21 January 2018

1 reference

The timing of glucocorticoid administration in rheumatoid arthritis

21 January 2018

1 reference

Systems biology reveals new strategies for personalizing cancer medicine and confirms the role of PTEN in resistance to trastuzumab.

21 January 2018

1 reference

Systems medicine: helping us understand the complexity of disease

21 January 2018

1 reference

Teratogenic effects of thalidomide: molecular mechanisms

21 January 2018

1 reference

Predicting new molecular targets for known drugs

21 January 2018

1 reference

PROMISCUOUS: a database for network-based drug-repositioning

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.1002/WSBM.1253

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