Glucokinase mediates coupling of glycolysis to mitochondrial metabolism but not to beta cell damage at high glucose exposure levels. (Q54597199)

1 June 2018

title

Glucokinase mediates coupling of glycolysis to mitochondrial metabolism but not to beta cell damage at high glucose exposure levels. (English)

1 reference

1 June 2018

0 references

H Schmitt

1

1 reference

1 June 2018

S Lenzen

series ordinal

2

1 reference

1 June 2018

S Baltrusch

series ordinal

3

1 reference

1 June 2018

publication date

12 April 2011

1 reference

1 June 2018

published in

Diabetologia

1 reference

1 June 2018

volume

54

1 reference

1 June 2018

page(s)

1744-1755

1 reference

1 June 2018

issue

7

1 reference

1 June 2018

https://scigraph.springernature.com/pub.10.1007/s00125-011-2133-5

exact match

0 references

cites work

Signal recognition by pancreatic B-cells

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2133-5

Banting Lecture 1995. A lesson in metabolic regulation inspired by the glucokinase glucose sensor paradigm

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2133-5

Sugar specificity of human beta-cell glucokinase: correlation of molecular models with kinetic measurements.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2133-5

Kinetic behaviour of vertebrate hexokinases with emphasis on hexokinase D (IV).

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2133-5

Mechanistic origin of the sigmoidal rate behaviour of rat liver hexokinase D ('glucokinase').

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2133-5

Structural basis for allosteric regulation of the monomeric allosteric enzyme human glucokinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2133-5

Conformational transition pathway in the allosteric process of human glucokinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2133-5

Binding kinetics of glucose and allosteric activators to human glucokinase reveal multiple conformational states.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2133-5

Sulfonylurea receptors and ATP-sensitive potassium ion channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2133-5

Triggering and amplifying pathways of regulation of insulin secretion by glucose

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2133-5

Perspective: emerging evidence for signaling roles of mitochondrial anaplerotic products in insulin secretion

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2133-5

Mitochondrial fusion and fission in mammals

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2133-5

Fission and selective fusion govern mitochondrial segregation and elimination by autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2133-5

Tagging and tracking individual networks within a complex mitochondrial web with photoactivatable GFP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2133-5

Frequency and selectivity of mitochondrial fusion are key to its quality maintenance function

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2133-5

Mitochondrial networking protects beta-cells from nutrient-induced apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2133-5

Role of mitochondrial dynamics proteins in the pathophysiology of obesity and type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2133-5

Mechanisms linking obesity to insulin resistance and type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2133-5

Glucolipotoxicity: fuel excess and beta-cell dysfunction.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2133-5

Fatty acids and glucolipotoxicity in the pathogenesis of Type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2133-5

Glucolipotoxicity of the pancreatic beta-cell: myth or reality?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2133-5

Saturated fatty acids synergize with elevated glucose to cause pancreatic beta-cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2133-5

Palmitate inhibition of insulin gene expression is mediated at the transcriptional level via ceramide synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2133-5

Glucose desensitization in INS-1 cells: evidence of impaired function caused by glucose metabolite(s) rather than by the glucose molecule per se.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2133-5

Glucose-induced toxicity in insulin-producing pituitary cells that coexpress GLUT2 and glucokinase. Implications for metabolic engineering

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2133-5

Acute glucose intolerance in insulinoma cells with unbalanced overexpression of glucokinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2133-5

High glucose-induced impairment in insulin secretion is associated with reduction in islet glucokinase in a mouse model of susceptibility to islet dysfunction

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2133-5

Exposure to chronic high glucose induces beta-cell apoptosis through decreased interaction of glucokinase with mitochondria: downregulation of glucokinase in pancreatic beta-cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2133-5

Monitoring of glucose-regulated single insulin secretory granule movement by selective photoactivation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2133-5

Interaction of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFK-2/FBPase-2) with glucokinase activates glucose phosphorylation and glucose metabolism in insulin-producing cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2133-5

Free fatty acids and cytokines induce pancreatic beta-cell apoptosis by different mechanisms: role of nuclear factor-kappaB and endoplasmic reticulum stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2133-5

Chronic palmitate exposure inhibits insulin secretion by dissociation of Ca(2+) channels from secretory granules

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2133-5

Peroxisome-generated hydrogen peroxide as important mediator of lipotoxicity in insulin-producing cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2133-5

Oxidative stress is a mediator of glucose toxicity in insulin-secreting pancreatic islet cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2133-5

Improved ecdysone receptor-based inducible gene regulation system

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2133-5

Improved metabolic stimulus for glucose-induced insulin secretion through GK and PFK-2/FBPase-2 coexpression in insulin-producing RINm5F cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2133-5

Glucokinase and glucose homeostasis: proven concepts and new ideas

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2133-5

A novel glucokinase activator modulates pancreatic islet and hepatocyte function

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2133-5

Glucolipotoxicity alters lipid partitioning and causes mitochondrial dysfunction, cholesterol, and ceramide deposition and reactive oxygen species production in INS832/13 ss-cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2133-5

Degradation of cAMP-responsive element-binding protein by the ubiquitin-proteasome pathway contributes to glucotoxicity in beta-cells and human pancreatic islets

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2133-5

Involvement of chronic stresses in rat islet and INS-1 cell glucotoxicity induced by intermittent high glucose.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2133-5

Glucose regulation of islet stress responses and beta-cell failure in type 2 diabetes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2133-5

Tight coupling between glucose and mitochondrial metabolism in clonal beta-cells is required for robust insulin secretion

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2133-5

Hyperglycemia induces apoptosis and p53 mobilization to mitochondria in RINm5F cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2133-5

The cell-type specificity of mitochondrial dynamics

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2133-5

-Cell Mitochondria Exhibit Membrane Potential Heterogeneity That Can Be Altered by Stimulatory or Toxic Fuel Levels

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2133-5

Subcellular heterogeneity of mitochondrial function and dysfunction: evidence obtained by confocal imaging

21 January 2018

1 reference

12 December 2020

Relation between antioxidant enzyme gene expression and antioxidative defense status of insulin-producing cells

1 reference

12 December 2020

Banting Lecture 1995. A lesson in metabolic regulation inspired by the glucokinase glucose sensor paradigm

1 reference

12 December 2020

A 48-hour lipid infusion in the rat time-dependently inhibits glucose-induced insulin secretion and B cell oxidation through a process likely coupled to fatty acid oxidation

1 reference

12 December 2020

10.1007/S00125-011-2133-5

Identifiers

DOI

1 reference

1 June 2018

PubMed ID

21484215

1 reference

1 June 2018