Mutational and DNA binding specificity of the carcinogen 2-amino-3, 8-dimethylimidazo[4,5-f]quinoxaline. (Q54583351)

1 June 2018

title

Mutational and DNA binding specificity of the carcinogen 2-amino-3, 8-dimethylimidazo[4,5-f]quinoxaline. (English)

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1 June 2018

author name string

Solomon MS

1

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Morgenthaler PM

2

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Turesky RJ

3

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Essigmann JM

4

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language of work or name

English

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publication date

1 August 1996

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Journal of Biological Chemistry

published in

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volume

271

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issue

31

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page(s)

18368-18374

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Carcinogenicity in rats of a mutagenic compound, 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline

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Characterization of DNA adducts formed in vitro by reaction of N-hydroxy-2-amino-3-methylimidazo[4,5-f]quinoline and N-hydroxy-2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline at the C-8 and N2 atoms of guanine.

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32P-postlabeling analysis of IQ, MeIQx and PhIP adducts formed in vitro in DNA and polynucleotides and found in vivo in hepatic DNA from IQ-, MeIQx- and PhIP-treated monkeys.

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Analysis of mutational specificity induced by heterocyclic amines in the lacZ gene of Escherichia coli.

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Mutational specificity of 2-nitro-3,4-dimethylimidazo[4,5-f]quinoline in the lacI gene of Escherichia coli.

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Detection of a Ha-ras point mutation by polymerase chain reaction-single strand conformation polymorphism analysis in 2-amino-3,4-dimethylimidazo[4,5-f]quinoline-induced mouse forestomach tumors

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Specific 5'-GGGA-3'-->5'-GGA-3' mutation of the Apc gene in rat colon tumors induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine

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New and versatile cloning vectors with kanamycin-resistance marker.

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Effects of DNA adduct structure and distribution on the mutagenicity and genotoxicity of two platinum anticancer drugs.

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Misalignment-mediated DNA synthesis errors

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DNA adduct-induced stabilization of slipped frameshift intermediates within repetitive sequences: implications for mutagenesis

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Infidelity of DNA synthesis associated with bypass of apurinic sites

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Mechanism of C8 alkylation of guanine residues by activated arylamines: evidence for initial adduct formation at the N7 position

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Mutational specificity of depurination

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Sensitivity of the conformation of deoxyguanosine to binding at the C-8 position by N-acetylated and unacetylated 2-aminofluorene

21 January 2018

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STRUCTURE OF A POTENT MUTAGEN ISOLATED FROM FRIED BEEF

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21 January 2018

Identifiers

DOI

10.1074/JBC.271.31.18368

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1 June 2018

PubMed ID

8702479

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1 June 2018