Phospholipid-induced monomerization and signal-peptide-induced oligomerization of SecA. (Q54535975)

31 May 2018

title

Phospholipid-induced monomerization and signal-peptide-induced oligomerization of SecA. (English)

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31 May 2018

author

Daniel L. Floyd

8

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Paul C Smith

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author name string

Jordi Benach

1

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31 May 2018

Yi-Te Chou

2

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31 May 2018

John J Fak

3

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31 May 2018

Anna Itkin

4

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31 May 2018

Daita D Nicolae

5

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31 May 2018

Paul C Smith

6

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31 May 2018

Guenther Wittrock

7

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31 May 2018

Cyrus M Golsaz

9

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31 May 2018

Lila M Gierasch

10

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31 May 2018

John F Hunt

11

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31 May 2018

language of work or name

English

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publication date

27 October 2002

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31 May 2018

Journal of Biological Chemistry

published in

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31 May 2018

volume

278

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31 May 2018

page(s)

3628-3638

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31 May 2018

issue

6

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31 May 2018

SecA promotes preprotein translocation by undergoing ATP-driven cycles of membrane insertion and deinsertion.

cites work

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205992200

SecA protein is exposed to the periplasmic surface of the E. coli inner membrane in its active state.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205992200

SecA membrane cycling at SecYEG is driven by distinct ATP binding and hydrolysis events and is regulated by SecD and SecF.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205992200

Both an N-terminal 65-kDa domain and a C-terminal 30-kDa domain of SecA cycle into the membrane at SecYEG during translocation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205992200

The ATPase activity of SecA is regulated by acidic phospholipids, SecY, and the leader and mature domains of precursor proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205992200

ΔμH+ and ATP function at different steps of the catalytic cycle of preprotein translocase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205992200

Cross-talk between catalytic and regulatory elements in a DEAD motor domain is essential for SecA function

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205992200

The structural basis of protein targeting and translocation in bacteria.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205992200

Bacterial preprotein translocase: mechanism and conformational dynamics of a processive enzyme.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205992200

The catalytic cycle of the escherichia coli SecA ATPase comprises two distinct preprotein translocation events

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205992200

Membrane-bound conformation of a signal peptide: a transferred nuclear Overhauser effect analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205992200

In vivo studies of the role of SecA during protein export in Escherichia coli

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205992200

The molecular chaperone SecB is released from the carboxy-terminus of SecA during initiation of precursor protein translocation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205992200

Functional signal peptides bind a soluble N-terminal fragment of SecA and inhibit its ATPase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205992200

Lipid and signal peptide-induced conformational changes within the C-domain of Escherichia coli SecA protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205992200

Phosphatidylglycerol is involved in protein translocation across Escherichia coli inner membranes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205992200

The purified E. coli integral membrane protein SecY/E is sufficient for reconstitution of SecA-dependent precursor protein translocation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205992200

SecA insertion into phospholipids is stimulated by negatively charged lipids and inhibited by ATP: a monolayer study

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205992200

Effects of nonlamellar-prone lipids on the ATPase activity of SecA bound to model membranes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205992200

Effects of lipids on the interaction of SecA with model membranes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205992200

The protease-protected 30 kDa domain of SecA is largely inaccessible to the membrane lipid phase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205992200

Complex behavior in solution of homodimeric SecA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205992200

Conformational stabilization and crystallization of the SecA translocation ATPase from Bacillus subtilis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205992200

Evaluating the oligomeric state of SecYEG in preprotein translocase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205992200

Projection structure and oligomeric properties of a bacterial core protein translocase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205992200

The SecYEG preprotein translocation channel is a conformationally dynamic and dimeric structure

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205992200

SecYEG assembles into a tetramer to form the active protein translocation channel

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205992200

Nucleotide control of interdomain interactions in the conformational reaction cycle of SecA

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205992200

Size-Distribution Analysis of Macromolecules by Sedimentation Velocity Ultracentrifugation and Lamm Equation Modeling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205992200

Size-distribution analysis of proteins by analytical ultracentrifugation: strategies and application to model systems

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205992200

Domain interactions of the peripheral preprotein Translocase subunit SecA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205992200

Importance of secondary structure in the signal sequence for protein secretion

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205992200

Novel secA alleles improve export of maltose-binding protein synthesized with a defective signal peptide

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205992200

Suppression of signal sequence defects and azide resistance in Escherichia coli commonly result from the same mutations in secA

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205992200

The enthalpy of acyl chain packing and the apparent water-accessible apolar surface area of phospholipids

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205992200

Autogenous translation regulation by Escherichia coli ATPase SecA may be mediated by an intrinsic RNA helicase activity of this protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205992200

Helicase structure and mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205992200

Crystal structure of a DEAD box protein from the hyperthermophile Methanococcus jannaschii

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205992200

Crystal structures of complexes of PcrA DNA helicase with a DNA substrate indicate an inchworm mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205992200

Modularity and specialization in superfamily 1 and 2 helicases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205992200

Major domain swiveling revealed by the crystal structures of complexes of E. coli Rep helicase bound to single-stranded DNA and ADP

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205992200

Mechanisms of helicase-catalyzed DNA unwinding

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205992200

Characterisation of Bacillus stearothermophilus PcrA helicase: evidence against an active rolling mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205992200

The helicase from hepatitis C virus is active as an oligomer

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205992200

Dissociation of the dimeric SecA ATPase during protein translocation across the bacterial membrane

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205992200

Escherichia coli SecA shape and dimensions

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205992200

A Single Amino Acid Substitution in SecY Stabilizes the Interaction with SecA

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205992200

Synthetic signal peptides specifically recognize SecA and stimulate ATPase activity in the absence of preprotein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205992200

Signal peptide determinants of SecA binding and stimulation of ATPase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205992200

The high affinity ATP binding site modulates the SecA-precursor interaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205992200

Non-bilayer Lipids Stimulate the Activity of the Reconstituted Bacterial Protein Translocase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205992200

Translocase-Bound SecA Is Largely Shielded from the Phospholipid Acyl Chains†

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205992200

SecA folds via a dimeric intermediate

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205992200

Nucleotide binding activity of SecA homodimer is conformationally regulated by temperature and altered by prlD and azi mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205992200

Allosteric effects of nucleotide cofactors on Escherichia coli Rep helicase-DNA binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205992200

21 January 2018

Identifiers

DOI

10.1074/JBC.M205992200

1 reference

31 May 2018

PubMed ID

12403785

1 reference

31 May 2018