Association of PTEN gene methylation with genetic alterations in the phosphatidylinositol 3-kinase/AKT signaling pathway in thyroid tumors. (Q54513531)

30 May 2018

title

Association of PTEN gene methylation with genetic alterations in the phosphatidylinositol 3-kinase/AKT signaling pathway in thyroid tumors. (English)

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30 May 2018

author name string

Peng Hou

series ordinal

1

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30 May 2018

Meiju Ji

series ordinal

2

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30 May 2018

Mingzhao Xing

series ordinal

3

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30 May 2018

language of work or name

English

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publication date

1 November 2008

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30 May 2018

published in

Cancer

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30 May 2018

volume

113

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30 May 2018

issue

9

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30 May 2018

page(s)

2440-2447

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30 May 2018

Quantitative assessment of promoter hypermethylation during breast cancer development

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Differential nuclear and cytoplasmic expression of PTEN in normal thyroid tissue, and benign and malignant epithelial thyroid tumors

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A National Cancer Data Base report on 53,856 cases of thyroid carcinoma treated in the U.S., 1985-1995 [see commetns]

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7 January 2021

Anaplastic thyroid carcinoma: behavior, biology, and therapeutic approaches.

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Anaplastic thyroid carcinoma: an overview

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PI3K/Akt signalling pathway and cancer.

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Oncogenic PI3K and its role in cancer

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7 January 2021

Increased expression of phosphorylated p70S6 kinase and Akt in papillary thyroid cancer tissues.

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7 January 2021

Akt activation and localisation correlate with tumour invasion and oncogene expression in thyroid cancer

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Akt: a potential target for thyroid cancer therapy

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7 January 2021

Uncommon Mutation, but Common Amplifications, of thePIK3CAGene in Thyroid Tumors

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7 January 2021

Mutation of the PIK3CA gene in anaplastic thyroid cancer.

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7 January 2021

Genetic alterations and their relationship in the phosphatidylinositol 3-kinase/Akt pathway in thyroid cancer

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7 January 2021

High prevalence and mutual exclusivity of genetic alterations in the phosphatidylinositol-3-kinase/akt pathway in thyroid tumors

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7 January 2021

Phosphatidylinositol 3-kinase/akt and ras/raf-mitogen-activated protein kinase pathway mutations in anaplastic thyroid cancer

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7 January 2021

The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate

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7 January 2021

PTEN: a tumour suppressor that functions as a phospholipid phosphatase

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7 January 2021

The lipid phosphatase activity of PTEN is critical for its tumor supressor function

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7 January 2021

Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN

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7 January 2021

The biology and clinical relevance of the PTEN tumor suppressor pathway

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7 January 2021

PTEN promoter methylation in sporadic thyroid carcinomas.

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7 January 2021

CpG island methylation of tumor-related promoters occurs preferentially in undifferentiated carcinoma

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7 January 2021

Gene methylation in thyroid tumorigenesis

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7 January 2021

Early occurrence of RASSF1A hypermethylation and its mutual exclusion with BRAF mutation in thyroid tumorigenesis.

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7 January 2021

CpG island methylator phenotype underlies sporadic microsatellite instability and is tightly associated with BRAF mutation in colorectal cancer

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7 January 2021

Association of aberrant methylation of tumor suppressor genes with tumor aggressiveness and BRAF mutation in papillary thyroid cancer

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7 January 2021

Loss of expression of the PTEN gene protein product is associated with poor outcome in breast cancer

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7 January 2021

https://api.crossref.org/works/10.1002%2FCNCR.23869

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7 January 2021

PTEN expression is reduced in a subset of sporadic thyroid carcinomas: evidence that PTEN-growth suppressing activity in thyroid cancer cells mediated by p27kip1

1 reference

https://api.crossref.org/works/10.1002%2FCNCR.23869

7 January 2021

Molecular pathobiology of thyroid neoplasms

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7 January 2021

Somatic mutations of the PTEN tumor suppressor gene in sporadic follicular thyroid tumors

1 reference

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7 January 2021

Fine-structure deletion mapping of 10q22-24 identifies regions of loss of heterozygosity and suggests that sporadic follicular thyroid adenomas and follicular thyroid carcinomas develop along distinct neoplastic pathways

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https://api.crossref.org/works/10.1002%2FCNCR.23869

7 January 2021

Epigenetic gene silencing in cancer – a mechanism for early oncogenic pathway addiction?

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7 January 2021

Decreased T cell ERK pathway signaling may contribute to the development of lupus through effects on DNA methylation and gene expression

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7 January 2021

Ras-mediated loss of the pro-apoptotic response protein Par-4 is mediated by DNA hypermethylation through Raf-independent and Raf-dependent signaling cascades in epithelial cells

1 reference

https://api.crossref.org/works/10.1002%2FCNCR.23869

7 January 2021

Inhibition of the extracellular signal-regulated kinase/mitogen-activated protein kinase pathway decreases DNA methylation in colon cancer cells

1 reference

https://api.crossref.org/works/10.1002%2FCNCR.23869

7 January 2021

Suppression of BRAF/MEK/MAP kinase pathway restores expression of iodide-metabolizing genes in thyroid cells expressing the V600E BRAF mutant.

1 reference

https://api.crossref.org/works/10.1002%2FCNCR.23869

7 January 2021

Silencing of the tumor suppressor gene SLC5A8 is associated with BRAF mutations in classical papillary thyroid carcinomas

1 reference

https://api.crossref.org/works/10.1002%2FCNCR.23869

7 January 2021

Identifiers

DOI

10.1002/CNCR.23869

1 reference

30 May 2018

PubMed ID

18831514

1 reference

30 May 2018