Strategies to generate biological reagents for kinase drug discovery. (Q54507967)

30 May 2018

title

Strategies to generate biological reagents for kinase drug discovery. (English)

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30 May 2018

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Namir J Hassan

1

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30 May 2018

Sheraz Gul

series ordinal

2

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30 May 2018

language of work or name

English

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publication date

9 November 2011

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30 May 2018

Expert Opinion on Drug Discovery

published in

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30 May 2018

volume

6

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30 May 2018

issue

12

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30 May 2018

page(s)

1215-1225

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30 May 2018

Protein kinases--the major drug targets of the twenty-first century?

cites work

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.635140

The protein kinase complement of the human genome

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.635140

21 January 2018

Targeted cancer therapy

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.635140

21 January 2018

Erlotinib hydrochloride

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.635140

High-throughput screening: update on practices and success

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.635140

Impact of high-throughput screening in biomedical research

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.635140

The challenge of selecting protein kinase assays for lead discovery optimization

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.635140

How were new medicines discovered?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.635140

Application of division arrest technology to cell-based HTS: comparison with frozen and fresh cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.635140

Cryopreserved cells facilitate cell-based drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.635140

Targeting cancer with small molecule kinase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.635140

Studies leading to the identification of ZD1839 (IRESSA): an orally active, selective epidermal growth factor receptor tyrosine kinase inhibitor targeted to the treatment of cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.635140

Biochemical and cellular effects of roscovitine, a potent and selective inhibitor of the cyclin-dependent kinases cdc2, cdk2 and cdk5.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.635140

A new paradigm for protein kinase inhibition: blocking phosphorylation without directly targeting ATP binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.635140

Allosteric activators of glucokinase: potential role in diabetes therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.635140

Identification and characterization of pleckstrin-homology-domain-dependent and isoenzyme-specific Akt inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.635140

Targeting Bcr–Abl by combining allosteric with ATP-binding-site inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.635140

Allosteric inhibitors of Bcr-abl-dependent cell proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.635140

Development of an insect-cell-based assay for detection of kinase inhibition using NF-kappaB-inducing kinase as a paradigm

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.635140

Mechanistic considerations in high-throughput screening

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.635140

Association of polymorphisms in AKT1 and EGFR with clinical outcome and toxicity in non-small cell lung cancer patients treated with gefitinib.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.635140

GATEWAY recombinational cloning: application to the cloning of large numbers of open reading frames or ORFeomes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.635140

Construction of mutant and chimeric genes using the polymerase chain reaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.635140

The univector plasmid-fusion system, a method for rapid construction of recombinant DNA without restriction enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.635140

Baculovirus expression system for heterologous multiprotein complexes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.635140

Folding aggregated proteins into functionally active forms

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.635140

Enhancement of soluble protein expression through the use of fusion tags

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.635140

Construction of a set Gateway-based destination vectors for high-throughput cloning and expression screening in Escherichia coli

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.635140

Comparison of SUMO fusion technology with traditional gene fusion systems: enhanced expression and solubility with SUMO.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.635140

Production of soluble mammalian proteins in Escherichia coli: identification of protein features that correlate with successful expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.635140

Baculovirus as versatile vectors for protein expression in insect and mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.635140

High-yield production and characterization of biologically active GST-tagged human topoisomerase IIα protein in insect cells for the development of a high-throughput assay

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.635140

From gene to protein: a review of new and enabling technologies for multi-parallel protein expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.635140

Developing baculovirus-insect cell expression systems for humanized recombinant glycoprotein production

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.635140

A baculovirus expression vector system for simultaneous protein expression in insect and mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.635140

Utility of large-scale transiently transfected cells for cell-based high-throughput screens to identify transient receptor potential channel A1 (TRPA1) antagonists

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.635140

10.1517/17460441.2011.635140

21 January 2018

Identifiers

DOI

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30 May 2018

PubMed ID

22647062

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30 May 2018