Transcriptional characteristics of CD4+ T cells in multiple sclerosis: relative lack of suppressive populations in blood. (Q54410992)

29 May 2018

title

Transcriptional characteristics of CD4+ T cells in multiple sclerosis: relative lack of suppressive populations in blood. (English)

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29 May 2018

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4

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author name string

M Edström

1

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29 May 2018

J Mellergård

2

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J Mjösberg

3

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M Vrethem

5

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R Press

6

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C Dahle

7

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J Ernerudh

8

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publication date

16 September 2010

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29 May 2018

Multiple Sclerosis Journal

published in

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volume

17

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issue

1

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page(s)

57-66

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Multiple sclerosis: a complicated picture of autoimmunity.

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CD4+ effector cells default to the Th2 pathway in interferon gamma-deficient mice infected with Leishmania major

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Tbt-1, a new T-box transcription factor induced in activated Th1 and CD8+ T cells.

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A novel transcription factor, T-bet, directs Th1 lineage commitment

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The transcription factor GATA-3 is necessary and sufficient for Th2 cytokine gene expression in CD4 T cells

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The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells

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Foxp3 programs the development and function of CD4+CD25+ regulatory T cells

21 January 2018

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The inhibitory cytokine IL-35 contributes to regulatory T-cell function

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IL-35 is a novel cytokine with therapeutic effects against collagen-induced arthritis through the expansion of regulatory T cells and suppression of Th17 cells

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Maintenance of the Foxp3-dependent developmental program in mature regulatory T cells requires continued expression of Foxp3.

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Epstein-Barr virus-induced gene 3 negatively regulates IL-17, IL-22 and RORgamma t

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Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain

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Systemic reduction of functionally suppressive CD4dimCD25highFoxp3+ Tregs in human second trimester pregnancy is induced by progesterone and 17beta-estradiol.

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Increased frequency of CD4+ CD25+ regulatory T cells in the cerebrospinal fluid but not in the blood of multiple sclerosis patients.

21 January 2018

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Reduced suppressive effect of CD4+CD25high regulatory T cells on the T cell immune response against myelin oligodendrocyte glycoprotein in patients with multiple sclerosis.

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Loss of functional suppression by CD4+CD25+ regulatory T cells in patients with multiple sclerosis

21 January 2018

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Expression of Epstein-Barr virus-induced gene 3, an interleukin-12 p40-related molecule, throughout human pregnancy: involvement of syncytiotrophoblasts and extravillous trophoblasts

21 January 2018

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Human CD4+ CD25+ Foxp3+ regulatory T cells do not constitutively express IL-35.

21 January 2018

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21 January 2018

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Pathophysiology of multiple sclerosis

21 January 2018

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Interleukin-17 mRNA expression in blood and CSF mononuclear cells is augmented in multiple sclerosis

21 January 2018

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Interleukin-17 production in central nervous system-infiltrating T cells and glial cells is associated with active disease in multiple sclerosis

21 January 2018

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Gene-microarray analysis of multiple sclerosis lesions yields new targets validated in autoimmune encephalomyelitis

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21 January 2018

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C-C chemokine receptor 6-regulated entry of TH-17 cells into the CNS through the choroid plexus is required for the initiation of EAE.

21 January 2018

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Complex interactions among MHC haplotypes in multiple sclerosis: susceptibility and resistance

21 January 2018

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A predominant role for the HLA class II region in the association of the MHC region with multiple sclerosis

21 January 2018

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Secondary progressive in contrast to relapsing-remitting multiple sclerosis patients show a normal CD4+CD25+regulatory T-cell function and FOXP3 expression

21 January 2018

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21 January 2018

Identifiers

DOI

10.1177/1352458510381256

1 reference

29 May 2018

release_7uqj7yvlpffzvn7qh3kexl5o3i

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/7uqj7yvlpffzvn7qh3kexl5o3i

mapped directly with Wikidata item

24 November 2022

based on heuristic

PubMed ID

20847001

1 reference

29 May 2018