Losmapimod, a novel p38 mitogen-activated protein kinase inhibitor, in non-ST-segment elevation myocardial infarction: a randomised phase 2 trial. (Q54344574)

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English	Losmapimod, a novel p38 mitogen-activated protein kinase inhibitor, in non-ST-segment elevation myocardial infarction: a randomised phase 2 trial.	scientific article

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scholarly article

1 reference

Europe PubMed Central

28 May 2018

http://europepmc.org/abstract/MED/24930728

Losmapimod, a novel p38 mitogen-activated protein kinase inhibitor, in non-ST-segment elevation myocardial infarction: a randomised phase 2 trial. (English)

1 reference

Europe PubMed Central

28 May 2018

http://europepmc.org/abstract/MED/24930728

phase II clinical trial

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myocardial infarction

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inferred from title

Christopher B. Granger

18

object named as

Christopher B Granger

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Europe PubMed Central

28 May 2018

L Kristin Newby

1

object named as

L Kristin Newby

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Europe PubMed Central

28 May 2018

12

object named as

Amir Lerman

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Europe PubMed Central

28 May 2018

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ORCID Public Data File 2021

7

object named as

Gengqian Cai

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Europe PubMed Central

28 May 2018

http://europepmc.org/abstract/MED/24930728

author name string

Michael S Marber

2

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Europe PubMed Central

28 May 2018

http://europepmc.org/abstract/MED/24930728

Chiara Melloni

3

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Europe PubMed Central

28 May 2018

http://europepmc.org/abstract/MED/24930728

Lea Sarov-Blat

4

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Europe PubMed Central

28 May 2018

http://europepmc.org/abstract/MED/24930728

Laura H Aberle

5

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Europe PubMed Central

28 May 2018

http://europepmc.org/abstract/MED/24930728

Philip E Aylward

6

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Europe PubMed Central

28 May 2018

http://europepmc.org/abstract/MED/24930728

Robbert J de Winter

8

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Europe PubMed Central

28 May 2018

http://europepmc.org/abstract/MED/24930728

Christian W Hamm

9

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Europe PubMed Central

28 May 2018

http://europepmc.org/abstract/MED/24930728

John F Heitner

10

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Europe PubMed Central

28 May 2018

http://europepmc.org/abstract/MED/24930728

Raymond Kim

11

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Europe PubMed Central

28 May 2018

http://europepmc.org/abstract/MED/24930728

Manesh R Patel

13

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Europe PubMed Central

28 May 2018

http://europepmc.org/abstract/MED/24930728

Jean-Francois Tanguay

14

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Europe PubMed Central

28 May 2018

http://europepmc.org/abstract/MED/24930728

John J Lepore

15

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Europe PubMed Central

28 May 2018

http://europepmc.org/abstract/MED/24930728

Hussein R Al-Khalidi

16

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Europe PubMed Central

28 May 2018

http://europepmc.org/abstract/MED/24930728

Dennis L Sprecher

17

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Europe PubMed Central

28 May 2018

http://europepmc.org/abstract/MED/24930728

SOLSTICE Investigators

19

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28 May 2018

http://europepmc.org/abstract/MED/24930728

language of work or name

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publication date

12 June 2014

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28 May 2018

http://europepmc.org/abstract/MED/24930728

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Europe PubMed Central

28 May 2018

http://europepmc.org/abstract/MED/24930728

384

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http://europepmc.org/abstract/MED/24930728

9949

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http://europepmc.org/abstract/MED/24930728

1187-1195

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Europe PubMed Central

28 May 2018

http://europepmc.org/abstract/MED/24930728

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2814%2960417-7

7 January 2021

based on heuristic

inferred from DOI database lookup

New therapeutic targets in cardiology: p38 alpha mitogen-activated protein kinase for ischemic heart disease.

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https://api.crossref.org/works/10.1016%2FS0140-6736%2814%2960417-7

7 January 2021

based on heuristic

inferred from DOI database lookup

The p38 mitogen-activated protein kinase pathway--a potential target for intervention in infarction, hypertrophy, and heart failure

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https://api.crossref.org/works/10.1016%2FS0140-6736%2814%2960417-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Developing small molecules to inhibit kinases unkind to the heart: p38 MAPK as a case in point

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https://api.crossref.org/works/10.1016%2FS0140-6736%2814%2960417-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Mechanism and consequence of the autoactivation of p38α mitogen-activated protein kinase promoted by TAB1

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https://api.crossref.org/works/10.1016%2FS0140-6736%2814%2960417-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Inhibition of p38 mitogen-activated protein kinase decreases cardiomyocyte apoptosis and improves cardiac function after myocardial ischemia and reperfusion

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2814%2960417-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Selective inhibition of p38alpha MAPK improves cardiac function and reduces myocardial apoptosis in rat model of myocardial injury

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2814%2960417-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Inhibition of p38 MAPK during ischemia, but not reperfusion, effectively attenuates fatal arrhythmia in ischemia/reperfusion heart.

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2814%2960417-7

7 January 2021

based on heuristic

inferred from DOI database lookup

p38 mitogen-activated protein kinase inhibition improves cardiac function and attenuates left ventricular remodeling following myocardial infarction in the rat

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2814%2960417-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Inhibition of the p38 MAP kinase in vivo improves number and functional activity of vasculogenic cells and reduces atherosclerotic disease progression

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2814%2960417-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Inhibition of p38 mitogen-activated protein kinase reduces inflammation after coronary vascular injury in humans.

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2814%2960417-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Effects of p38 mitogen-activated protein kinase inhibition on vascular and systemic inflammation in patients with atherosclerosis.

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2814%2960417-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Inhibition of p38 mitogen-activated protein kinase improves nitric oxide-mediated vasodilatation and reduces inflammation in hypercholesterolemia.

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2814%2960417-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Safety, tolerability, pharmacokinetics and pharmacodynamics of losmapimod following a single intravenous or oral dose in healthy volunteers.

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2814%2960417-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Losmapimod concentration-QT relationship in healthy volunteers: meta-analysis of data from six clinical trials

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2814%2960417-7

7 January 2021

based on heuristic

inferred from DOI database lookup

The Study Of LoSmapimod treatment on inflammation and InfarCtSizE (SOLSTICE): Design and rationale

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2814%2960417-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Long-term but not short-term p38 mitogen-activated protein kinase inhibition improves cardiac function and reduces cardiac remodeling post-myocardial infarction

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2814%2960417-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Inhibition of p38 mitogen-activated protein kinase protects the heart against cardiac remodeling in mice with heart failure resulting from myocardial infarction

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2814%2960417-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

10.1016/S0140-6736(14)60417-7

1 reference

Europe PubMed Central

28 May 2018

http://europepmc.org/abstract/MED/24930728

1 reference

Europe PubMed Central

28 May 2018

http://europepmc.org/abstract/MED/24930728

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