CBL mutation-related patterns of phosphorylation and sensitivity to tyrosine kinase inhibitors. (Q54329349)

27 May 2018

title

CBL mutation-related patterns of phosphorylation and sensitivity to tyrosine kinase inhibitors. (English)

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27 May 2018

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H Makishima

1

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Y Sugimoto

2

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H Szpurka

3

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M J Clemente

4

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K P Ng

5

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H Muramatsu

6

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C O'Keefe

7

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Y Saunthararajah

8

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J P Maciejewski

9

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publication date

13 January 2012

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27 May 2018

published in

Leukemia

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volume

26

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issue

7

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page(s)

1547-1554

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https://scigraph.springernature.com/pub.10.1038/leu.2012.7

exact match

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cites work

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FLT3 signaling in hematopoietic cells involves CBL, SHC and an unknown P115 as prominent tyrosine-phosphorylated substrates

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The proto-oncogene product c-Cbl becomes tyrosine phosphorylated by stimulation with GM-CSF or Epo and constitutively binds to the SH3 domain of Grb2/Ash in human hematopoietic cells

21 January 2018

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Long-term survival after nonintensive chemotherapy in some juvenile myelomonocytic leukemia patients with CBL mutations, and the possible presence of healthy persons with the mutations

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inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/LEU.2012.7

1 reference

27 May 2018

PubMed ID

22246246

1 reference

27 May 2018