Nrf2 inhibits hepatic iron accumulation and counteracts oxidative stress-induced liver injury in nutritional steatohepatitis. (Q54321919)

27 May 2018

title

Nrf2 inhibits hepatic iron accumulation and counteracts oxidative stress-induced liver injury in nutritional steatohepatitis. (English)

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27 May 2018

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Kosuke Okada

1

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27 May 2018

Eiji Warabi

2

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27 May 2018

Hirokazu Sugimoto

3

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Masaki Horie

4

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Katsutoshi Tokushige

5

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Tetsuya Ueda

6

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Nobuhiko Harada

7

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Keiko Taguchi

8

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Etsuko Hashimoto

9

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27 May 2018

Ken Itoh

10

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Tetsuro Ishii

11

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Hirotoshi Utsunomiya

12

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Masayuki Yamamoto

13

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Junichi Shoda

14

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publication date

28 February 2012

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27 May 2018

Journal of Gastroenterology

published in

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volume

47

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issue

8

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27 May 2018

page(s)

924-935

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Diagnosis and therapy of nonalcoholic steatohepatitis

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Heme oxygenase-1 protects against steatohepatitis in both cultured hepatocytes and mice

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Lipid-induced oxidative stress causes steatohepatitis in mice fed an atherogenic diet.

21 January 2018

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Distinct Cysteine Residues in Keap1 Are Required for Keap1-Dependent Ubiquitination of Nrf2 and for Stabilization of Nrf2 by Chemopreventive Agents and Oxidative Stress

21 January 2018

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Ursodeoxycholic acid stimulates Nrf2-mediated hepatocellular transport, detoxification, and antioxidative stress systems in mice

21 January 2018

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Deletion of nuclear factor-E2-related factor-2 leads to rapid onset and progression of nutritional steatohepatitis in mice

21 January 2018

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Loss of Nrf2 markedly exacerbates nonalcoholic steatohepatitis.

21 January 2018

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Enhanced expression of Nrf2 in mice attenuates the fatty liver produced by a methionine- and choline-deficient diet

21 January 2018

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Nrf2 regulates ferroportin 1-mediated iron efflux and counteracts lipopolysaccharide-induced ferroportin 1 mRNA suppression in macrophages

21 January 2018

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Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization

21 January 2018

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Increased hepatic iron concentration in nonalcoholic steatohepatitis is associated with increased fibrosis.

21 January 2018

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Sulforaphane, an activator of Nrf2, suppresses cellular accumulation of arsenic and its cytotoxicity in primary mouse hepatocytes

21 January 2018

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21 January 2018

Human iron transporters

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Pioglitazone, vitamin E, or placebo for nonalcoholic steatohepatitis

21 January 2018

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The lipid peroxidation end product 4-hydroxy-2,3-nonenal up-regulates transforming growth factor beta1 expression in the macrophage lineage: a link between oxidative injury and fibrosclerosis

21 January 2018

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12 December 2020

Iron preloading aggravates nutritional steatohepatitis in rats by increasing apoptotic cell death

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Nrf2 counteracts cholestatic liver injury via stimulation of hepatic defense systems

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12 December 2020

Serum thioredoxin levels as a predictor of steatohepatitis in patients with nonalcoholic fatty liver disease

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12 December 2020

Role of transcription factor Nrf2 in the induction of hepatic phase 2 and antioxidative enzymes in vivo by the cancer chemoprotective agent, 3H-1, 2-dimethiole-3-thione

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10.1007/S00535-012-0552-9

Identifiers

DOI

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27 May 2018

PubMed ID

22367278

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27 May 2018