Fibroblast growth factor 1 (Q5425464)

http://www.ebi.ac.uk/interpro/protein/P05230

Cytokine IL1/FGF

1 reference

stated in

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P05230

1 reference

13 November 2019

1 reference

13 November 2019

1 reference

8 April 2019

Copper induces the assembly of a multiprotein aggregate implicated in the release of fibroblast growth factor 1 in response to stress

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05230

5 references

8 April 2019

Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05230

8 April 2019

Crystal structures of two FGF-FGFR complexes reveal the determinants of ligand-receptor specificity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05230

8 April 2019

Structural interactions of fibroblast growth factor receptor with its ligands

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05230

8 April 2019

Insights into the molecular basis for fibroblast growth factor receptor autoinhibition and ligand-binding promiscuity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05230

8 April 2019

Direct binding of integrin alphavbeta3 to FGF1 plays a role in FGF1 signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05230

Alternative splicing generates two forms of mRNA coding for human heparin-binding growth factor 1

IPI

growth factor activity

5 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05230

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05230

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05230

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05230

8 April 2019

Gentisic acid, a compound associated with plant defense and a metabolite of aspirin, heads a new class of in vivo fibroblast growth factor inhibitors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05230

protein tyrosine kinase activity

1 reference

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P05230&geneProductId=UniProtKB:P05230

phosphatidylinositol-4,5-bisphosphate 3-kinase activity

1 reference

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P05230&geneProductId=UniProtKB:P05230

fibroblast growth factor receptor binding

4 references

8 April 2019

Crystal structures of two FGF-FGFR complexes reveal the determinants of ligand-receptor specificity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05230

8 April 2019

Fibroblast growth factor (FGF) homologous factors share structural but not functional homology with FGFs

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05230

8 April 2019

Direct binding of integrin alphavbeta3 to FGF1 plays a role in FGF1 signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05230

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05230

1 reference

8 April 2019

Direct binding of integrin alphavbeta3 to FGF1 plays a role in FGF1 signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05230

1-phosphatidylinositol-3-kinase activity

1 reference

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P05230&geneProductId=UniProtKB:P05230

3 references

8 April 2019

Direct binding of integrin alphavbeta3 to FGF1 plays a role in FGF1 signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05230

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05230

8 April 2019

Gentisic acid, a compound associated with plant defense and a metabolite of aspirin, heads a new class of in vivo fibroblast growth factor inhibitors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05230

Hsp70 protein binding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05230

5 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05230

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05230

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05230

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05230

8 April 2019

S100A13 mediates the copper-dependent stress-induced release of IL-1α from both human U937 and murine NIH 3T3 cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05230

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05230

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05230

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05230

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05230

cellular response to heat

1 reference

8 April 2019

S100A13 mediates the copper-dependent stress-induced release of IL-1α from both human U937 and murine NIH 3T3 cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05230

positive regulation of protein phosphorylation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05230

positive regulation of MAP kinase activity

1 reference

8 April 2019

Fibroblast growth factor 16 and 18 are expressed in human cardiovascular tissues and induce on endothelial cells migration but not proliferation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05230

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05230

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05230

positive regulation of epithelial cell proliferation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05230

anatomical structure morphogenesis

1 reference

8 April 2019

Alternative splicing generates two forms of mRNA coding for human heparin-binding growth factor 1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05230

positive regulation of intracellular signal transduction

1 reference

8 April 2019

FGF-1 induces expression of LXRalpha and production of 25-hydroxycholesterol to upregulate the apoE gene in rat astrocytes

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05230

branch elongation involved in ureteric bud branching

1 reference

8 April 2019

Multiple fibroblast growth factors support growth of the ureteric bud but have different effects on branching morphogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05230

positive regulation of angiogenesis

1 reference

8 April 2019

Gentisic acid, a compound associated with plant defense and a metabolite of aspirin, heads a new class of in vivo fibroblast growth factor inhibitors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05230

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05230

mesonephric epithelium development

1 reference

8 April 2019

Multiple fibroblast growth factors support growth of the ureteric bud but have different effects on branching morphogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05230

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05230

regulation of endothelial cell chemotaxis to fibroblast growth factor

1 reference

8 April 2019

Fibroblast growth factor 16 and 18 are expressed in human cardiovascular tissues and induce on endothelial cells migration but not proliferation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05230

positive regulation of cholesterol biosynthetic process

1 reference

8 April 2019

FGF-1 induces expression of LXRalpha and production of 25-hydroxycholesterol to upregulate the apoE gene in rat astrocytes

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05230

cell population proliferation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05230

1 reference

8 April 2019

Amino acid sequence of human acidic fibroblast growth factor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05230

phosphatidylinositol phosphate biosynthetic process

NAS

1 reference

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P05230&geneProductId=UniProtKB:P05230

peptidyl-tyrosine phosphorylation

1 reference

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P05230&geneProductId=UniProtKB:P05230

positive regulation of sprouting angiogenesis

1 reference

8 April 2019

A dominant-negative FGF1 mutant (the R50E mutant) suppresses tumorigenesis and angiogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05230

fibroblast growth factor receptor signaling pathway

7 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05230

8 April 2019

Crystal structures of two FGF-FGFR complexes reveal the determinants of ligand-receptor specificity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05230

8 April 2019

Direct binding of integrin alphavbeta3 to FGF1 plays a role in FGF1 signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05230

8 April 2019

betaKlotho is required for fibroblast growth factor (FGF) 21 signaling through FGF receptor (FGFR) 1c and FGFR3c

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05230

8 April 2019

Receptor specificity of the fibroblast growth factor family

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05230

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05230

8 April 2019

Gentisic acid, a compound associated with plant defense and a metabolite of aspirin, heads a new class of in vivo fibroblast growth factor inhibitors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05230

positive regulation of cell population proliferation

4 references

8 April 2019

Direct binding of integrin alphavbeta3 to FGF1 plays a role in FGF1 signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05230

8 April 2019

A dominant-negative FGF1 mutant (the R50E mutant) suppresses tumorigenesis and angiogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05230

8 April 2019

betaKlotho is required for fibroblast growth factor (FGF) 21 signaling through FGF receptor (FGFR) 1c and FGFR3c

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05230

8 April 2019

Receptor specificity of the fibroblast growth factor family

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05230

phosphatidylinositol-3-phosphate biosynthetic process

IGI

1 reference

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P05230&geneProductId=UniProtKB:P05230

regulation of endothelial tube morphogenesis

1 reference

8 April 2019

A dominant-negative FGF1 mutant (the R50E mutant) suppresses tumorigenesis and angiogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05230

positive regulation of cell migration

positive regulation of endothelial cell migration

1 reference

8 April 2019

A dominant-negative FGF1 mutant (the R50E mutant) suppresses tumorigenesis and angiogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05230

activation of protein kinase B activity

1 reference

8 April 2019

Direct binding of integrin alphavbeta3 to FGF1 plays a role in FGF1 signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05230

regulation of signaling receptor activity

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05230

positive regulation of protein kinase B signaling

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05230

Gene Atlas image

PBB GE FGF1 205117 at fs.png
732 × 530; 10 KB

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Identifiers

MeSH descriptor ID

D016220

subject named as

Fibroblast Growth Factor 1

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13 November 2019

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