Preclinical development of keliximab, a Primatized anti-CD4 monoclonal antibody, in human CD4 transgenic mice: characterization of the model and safety studies. (Q54042570)

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English	Preclinical development of keliximab, a Primatized anti-CD4 monoclonal antibody, in human CD4 transgenic mice: characterization of the model and safety studies.	scientific article

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8 November 2019

Preclinical development of keliximab, a Primatized anti-CD4 monoclonal antibody, in human CD4 transgenic mice: characterization of the model and safety studies (English)

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8 November 2019

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8 November 2019

author name string

P J Bugelski

1

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8 November 2019

D J Herzyk

2

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8 November 2019

S Rehm

3

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8 November 2019

A G Harmsen

4

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8 November 2019

E V Gore

5

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8 November 2019

D M Williams

6

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8 November 2019

B E Maleeff

7

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A M Badger

8

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A Truneh

9

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S R O'Brien

10

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R A Macia

11

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P J Wier

12

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T K Hart

14

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publication date

1 April 2000

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8 November 2019

Human & Experimental Toxicology

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19

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4

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230-243

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8 November 2019

The regulation of CD4 and CD8 coreceptor gene expression during T cell development

1 reference

https://api.crossref.org/works/10.1191%2F096032700678815783

21 January 2018

The CD4 and CD8 T cell surface antigens are associated with the internal membrane tyrosine-protein kinase p56lck

1 reference

https://api.crossref.org/works/10.1191%2F096032700678815783

21 January 2018

T cells and chronic asthma

1 reference

https://api.crossref.org/works/10.1191%2F096032700678815783

21 January 2018

A primatized MAb to human CD4 causes receptor modulation, without marked reduction in CD4+ T cells in chimpanzees: in vitro and in vivo characterization of a MAb (IDEC-CE9.1) to human CD4.

1 reference

https://api.crossref.org/works/10.1191%2F096032700678815783

21 January 2018

Randomised, dose-ranging, placebo-controlled study of chimeric antibody to CD4 (keliximab) in chronic severe asthma

1 reference

https://api.crossref.org/works/10.1191%2F096032700678815783

21 January 2018

Flow cytometry in the preclinical development of biopharmaceuticals

1 reference

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21 January 2018

Correlation of murine susceptibility to tumor, parasite and bacterial challenge with altered cell-mediated immunity following systemic exposure to the tumor promoter phorbol myristate acetate.

1 reference

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21 January 2018

Requirement for CD4+ cells in resistance to Pneumocystis carinii pneumonia in mice

1 reference

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21 January 2018

Mutant and transgenic mice in immunotoxicology: an introduction

1 reference

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Transgenic animals in the evaluation of compound efficacy and toxicity: will they be as useful as they are novel?

1 reference

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21 January 2018

The U.S. National Toxicology Program evaluation of transgenic mice as predictive models for identifying carcinogens

1 reference

https://api.crossref.org/works/10.1191%2F096032700678815783

21 January 2018

Identification of a CD4 binding site on the beta 2 domain of HLA-DR molecules.

1 reference

https://api.crossref.org/works/10.1191%2F096032700678815783

21 January 2018

Identification of human CD4 residues affecting class II MHC versus HIV-1 gp120 binding

1 reference

https://api.crossref.org/works/10.1191%2F096032700678815783

21 January 2018

Interaction between CD4 and class II MHC molecules mediates cell adhesion

1 reference

https://api.crossref.org/works/10.1191%2F096032700678815783

21 January 2018

Requirement for association of p56lck with CD4 in antigen-specific signal transduction in T cells

1 reference

https://api.crossref.org/works/10.1191%2F096032700678815783

21 January 2018

Equivalence of human and mouse CD4 in enhancing antigen responses by a mouse class II-restricted T cell hybridoma

1 reference

https://api.crossref.org/works/10.1191%2F096032700678815783

21 January 2018

CD4+ helper T cells are required for resistance to a highly metastatic murine tumor.

1 reference

https://api.crossref.org/works/10.1191%2F096032700678815783

21 January 2018

Role of CD4 in thymocyte selection and maturation

1 reference

https://api.crossref.org/works/10.1191%2F096032700678815783

21 January 2018

A new model of Pneumocystis carinii infection in mice selectively depleted of helper T lymphocytes

1 reference

https://api.crossref.org/works/10.1191%2F096032700678815783

21 January 2018

Identifiers

10.1191/096032700678815783

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10918514%20AND%20SRC:MED&resulttype=core&format=json

8 November 2019

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10918514%20AND%20SRC:MED&resulttype=core&format=json

8 November 2019

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