Overproduction and identification of butyrolactones SCB1-8 in the antibiotic production superhost Streptomyces M1152. (Q53722313)

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1 April 2020

title

Overproduction and identification of butyrolactones SCB1-8 in the antibiotic production superhost Streptomyces M1152 (English)

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1 April 2020

main subject

antibiotic

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Streptomyces coelicolor

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Streptomyces albidoflavus

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(2R,3R,6R)-Virginiae butanolide A

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Virginiaebutanolide C, >=90% (LC/MS-ELSD)

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(3R,4R)-3-[(1R)-1-hydroxyheptyl]-4-(hydroxymethyl)oxolan-2-one

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(3R,4R)-4-(hydroxymethyl)-3-[(1R)-1-hydroxynonyl]oxolan-2-one

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(3R,4R)-4-(hydroxymethyl)-3-[(1R)-1-hydroxy-4-methylhexyl]oxolan-2-one

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(3R,4R)-4-(hydroxymethyl)-3-[(1R)-1-hydroxy-6-methyloctyl]oxolan-2-one

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6

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1 April 2020

author name string

John D Sidda

1

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1 April 2020

Vincent Poon

2

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1 April 2020

Lijiang Song

3

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1 April 2020

Weishan Wang

4

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Keqian Yang

5

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publication date

1 July 2016

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full work available at URL

1 April 2020

https://pubs.rsc.org/en/content/articlepdf/2016/ob/c6ob00840b

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19 March 2024

https://api.unpaywall.org/v2/10.1039/c6ob00840b?email=unpaywall_01@example.com

published in

Organic and Biomolecular Chemistry

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volume

14

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issue

27

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page(s)

6390-6393

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1 April 2020

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19 March 2024

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access restriction status

open access

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based on heuristic

inferred from online access status

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Purification and structural determination of SCB1, a gamma-butyrolactone that elicits antibiotic production in Streptomyces coelicolor A3(2)

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Analysis of two additional signaling molecules in Streptomyces coelicolor and the development of a butyrolactone-specific reporter system

21 January 2018

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ScbA from Streptomyces coelicolor A3(2) has homology to fatty acid synthases and is able to synthesize -butyrolactones

21 January 2018

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Biosynthesis of gamma-butyrolactone autoregulators that switch on secondary metabolism and morphological development in Streptomyces.

21 January 2018

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A bacterial hormone (the SCB1) directly controls the expression of a pathway-specific regulatory gene in the cryptic type I polyketide biosynthetic gene cluster of Streptomyces coelicolor

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Deletion of a regulatory gene within the cpk gene cluster reveals novel antibacterial activity in Streptomyces coelicolor A3(2).

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A novel role of 'pseudo'γ-butyrolactone receptors in controlling γ-butyrolactone biosynthesis in Streptomyces.

21 January 2018

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ScbR- and ScbR2-mediated signal transduction networks coordinate complex physiological responses in Streptomyces coelicolor

21 January 2018

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Engineering Streptomyces coelicolor for heterologous expression of secondary metabolite gene clusters.

21 January 2018

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Fragmentation study on butanolides with tandem mass spectrometry and its application for the screening of ScbR-captured quorum sensing molecules in Streptomyces coelicolor A3(2).

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A butenolide intermediate in methylenomycin furan biosynthesis is implied by incorporation of stereospecifically 13C-labelled glycerols

21 January 2018

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21 January 2018

Identifiers

DOI

10.1039/C6OB00840B

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27180870%20AND%20SRC:MED&resulttype=core&format=json

1 April 2020

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