Robust CD4+ and CD8+ T cell responses to SIV using mRNA-transfected DC expressing autologous viral Ag. (Q53717620)

18 May 2018

title

Robust CD4+ and CD8+ T cell responses to SIV using mRNA-transfected DC expressing autologous viral Ag. (English)

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18 May 2018

author name string

Nada M Melhem

1

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18 May 2018

Xiang Dong Liu

2

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18 May 2018

David Boczkowski

3

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18 May 2018

Eli Gilboa

4

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18 May 2018

Simon M Barratt-Boyes

5

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18 May 2018

publication date

1 August 2007

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18 May 2018

European Journal of Immunology

published in

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18 May 2018

volume

37

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18 May 2018

page(s)

2164-2173

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18 May 2018

issue

8

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18 May 2018

Adenovirus-transduced dendritic cells injected into skin or lymph node prime potent simian immunodeficiency virus-specific T cell immunity in monkeys

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HIV gag mRNA transfection of dendritic cells (DC) delivers encoded antigen to MHC class I and II molecules, causes DC maturation, and induces a potent human in vitro primary immune response.

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Injection of immature dendritic cells into adjuvant-treated skin obviates the need for ex vivo maturation

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Virus-specific CD8+ cytotoxic T-lymphocyte activity associated with control of viremia in primary human immunodeficiency virus type 1 infection

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Loss of HIV-1-specific CD8+ T cell proliferation after acute HIV-1 infection and restoration by vaccine-induced HIV-1-specific CD4+ T cells

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Vigorous HIV-1-specific CD4+ T cell responses associated with control of viremia

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Dendritic cells and the promise of therapeutic vaccines for human immunodeficiency virus (HIV)-1.

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Diversity considerations in HIV-1 vaccine selection

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7 January 2021

HIV and SIV CTL escape: implications for vaccine design

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Tat-specific cytotoxic T lymphocytes select for SIV escape variants during resolution of primary viraemia

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Antiviral pressure exerted by HIV-1-specific cytotoxic T lymphocytes (CTLs) during primary infection demonstrated by rapid selection of CTL escape virus

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Late escape from an immunodominant cytotoxic T-lymphocyte response associated with progression to AIDS

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Acute phase cytotoxic T lymphocyte escape is a hallmark of simian immunodeficiency virus infection

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Immunobiology of dendritic cells

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Dendritic cells: controllers of the immune system and a new promise for immunotherapy

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7 January 2021

Mature dendritic cells infected with canarypox virus elicit strong anti-human immunodeficiency virus CD8+ and CD4+ T-cell responses from chronically infected individuals

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In vitro human immunodeficiency virus eradication by autologous CD8(+) T cells expanded with inactivated-virus-pulsed dendritic cells

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7 January 2021

Macaque dendritic cells infected with SIV-recombinant canarypox ex vivo induce SIV-specific immune responses in vivo

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7 January 2021

Protection by dendritic cells-based HIV synthetic peptide cocktail vaccine: preclinical studies in the SHIV-rhesus model

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Induction of potent human immunodeficiency virus type 1-specific T-cell-restricted immunity by genetically modified dendritic cells

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Preclinical full-scale evaluation of dendritic cells transfected with autologous tumor-mRNA for melanoma vaccination

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Efficient stimulation of HIV-1-specific T cells using dendritic cells electroporated with mRNA encoding autologous HIV-1 Gag and Env proteins.

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7 January 2021

Expansion of HIV-specific CD4+ and CD8+ T cells by dendritic cells transfected with mRNA encoding cytoplasm- or lysosome-targeted Nef

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7 January 2021

Maturation and trafficking of monocyte-derived dendritic cells in monkeys: implications for dendritic cell-based vaccines

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7 January 2021

Human dendritic cells transfected with either RNA or DNA encoding influenza matrix protein M1 differ in their ability to stimulate cytotoxic T lymphocytes

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7 January 2021

mRNA but not plasmid DNA is efficiently transfected in murine J774A.1 macrophages.

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7 January 2021

Highly efficient gene delivery by mRNA electroporation in human hematopoietic cells: superiority to lipofection and passive pulsing of mRNA and to electroporation of plasmid cDNA for tumor antigen loading of dendritic cells

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7 January 2021

Autologous dendritic cells transfected with prostate-specific antigen RNA stimulate CTL responses against metastatic prostate tumors

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7 January 2021

mRNA is an endogenous ligand for Toll-like receptor 3.

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7 January 2021

Double-stranded secondary structures on mRNA induce type I interferon (IFN alpha/beta) production and maturation of mRNA-transfected monocyte-derived dendritic cells

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7 January 2021

Broad cellular immunity with robust memory responses to simian immunodeficiency virus following serial vaccination with adenovirus 5- and 35-based vectors.

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7 January 2021

Telomerase mRNA-transfected dendritic cells stimulate antigen-specific CD8+ and CD4+ T cell responses in patients with metastatic prostate cancer

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7 January 2021

Quantification of latent tissue reservoirs and total body viral load in HIV-1 infection

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7 January 2021

Identification of a reservoir for HIV-1 in patients on highly active antiretroviral therapy

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7 January 2021

Immune control of HIV: the obstacles of HLA and viral diversity

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7 January 2021

Selective escape from CD8+ T-cell responses represents a major driving force of human immunodeficiency virus type 1 (HIV-1) sequence diversity and reveals constraints on HIV-1 evolution

1 reference

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7 January 2021

Interleukin-12 production by leukemia-derived dendritic cells counteracts the inhibitory effect of leukemic microenvironment on T cells

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7 January 2021

Human cytokine-induced killer cells have enhanced in vitro cytolytic activity via non-viral interleukin-2 gene transfer

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7 January 2021

Nucleofection of primary neurons.

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7 January 2021

mRNA-based electrotransfection of human dendritic cells and induction of cytotoxic T lymphocyte responses against the telomerase catalytic subunit (hTERT)

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7 January 2021

Selected Toll-like receptor agonist combinations synergistically trigger a T helper type 1-polarizing program in dendritic cells

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7 January 2021

Control of human immunodeficiency virus replication by cytotoxic T lymphocytes targeting subdominant epitopes

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7 January 2021

Competition Between CTL Narrows the Immune Response Induced by Prime-Boost Vaccination Protocols

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7 January 2021

De novo generation of escape variant-specific CD8+ T-cell responses following cytotoxic T-lymphocyte escape in chronic human immunodeficiency virus type 1 infection

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https://api.crossref.org/works/10.1002%2FEJI.200636782

7 January 2021

Enhanced detection of human immunodeficiency virus type 1-specific T-cell responses to highly variable regions by using peptides based on autologous virus sequences

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https://api.crossref.org/works/10.1002%2FEJI.200636782

7 January 2021

Role of Cellular Immunity in Protection against HIV Infection**This article was accepted for publication on 31 October 1996

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7 January 2021

Correlates of immune protection in HIV-1 infection: what we know, what we don't know, what we should know

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7 January 2021

Synergy between tumor immunotherapy and antiangiogenic therapy

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https://api.crossref.org/works/10.1002%2FEJI.200636782

7 January 2021

Identifiers

DOI

10.1002/EJI.200636782

1 reference

18 May 2018

PubMed ID

17615585

1 reference

18 May 2018