Thrombin mediates mitogenesis and survival of human endothelial cells through distinct mechanisms. (Q53489284)

14 May 2018

title

Thrombin mediates mitogenesis and survival of human endothelial cells through distinct mechanisms. (English)

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14 May 2018

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Panagiota Zania

1

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14 May 2018

Matthew Papaconstantinou

2

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14 May 2018

Christodoulos S Flordellis

3

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14 May 2018

Michael E Maragoudakis

4

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14 May 2018

Nikos E Tsopanoglou

5

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14 May 2018

publication date

26 March 2008

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14 May 2018

American Journal of Physiology - Cell Physiology

published in

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14 May 2018

volume

294

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14 May 2018

issue

5

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page(s)

C1215-26

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14 May 2018

Evidence for ERK1/2 activation by thrombin that is independent of EGFR transactivation.

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Thrombin induces neoangiogenesis in the chick chorioallantoic membrane

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Thrombin induces rapid PAR1-mediated non-classical FGF1 release

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Inflammation and the activated protein C anticoagulant pathway

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Protective signaling by activated protein C is mechanistically linked to protein C activation on endothelial cells.

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Proteinase-activated receptor 1 (PAR-1) and cell apoptosis

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Akt mediates cytoprotection of endothelial cells by vascular endothelial growth factor in an anchorage-dependent manner

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Nitric oxide-generating vasodilators and 8-bromo-cyclic guanosine monophosphate inhibit mitogenesis and proliferation of cultured rat vascular smooth muscle cells

21 January 2018

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Vascular endothelial growth factor regulates endothelial cell survival through the phosphatidylinositol 3'-kinase/Akt signal transduction pathway. Requirement for Flk-1/KDR activation

21 January 2018

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Thrombin induces increased expression and secretion of angiopoietin-2 from human umbilical vein endothelial cells

21 January 2018

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Angiopoietin-regulated recruitment of vascular smooth muscle cells by endothelial-derived heparin binding EGF-like growth factor

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Nitric oxide: an endogenous modulator of leukocyte adhesion

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Constitutive production and thrombin-induced release of vascular endothelial growth factor by human megakaryocytes and platelets

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Thrombin and vascular development: a sticky subject

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The role of the coagulation system in tumour angiogenesis

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Thrombomodulin prolongs thrombin-induced extracellular signal-regulated kinase phosphorylation and nuclear retention in endothelial cells

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Thrombin functions through its RGD sequence in a non-canonical conformation

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The epidermal growth factor receptor family as a central element for cellular signal transduction and diversification

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Thrombin- and factor Xa-induced DNA synthesis is mediated by transactivation of fibroblast growth factor receptor-1 in human vascular smooth muscle cells

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Protease-activated receptor-1-mediated DNA synthesis in cardiac fibroblast is via epidermal growth factor receptor transactivation: distinct PAR-1 signaling pathways in cardiac fibroblasts and cardiomyocytes

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U-61, 431F, a stable prostacyclin analogue, inhibits the proliferation of bovine vascular smooth muscle cells with little antiproliferative effect on endothelial cells

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Integrins regulate the linkage between upstream and downstream events in G protein-coupled receptor signaling to mitogen-activated protein kinase

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A protein kinase Cepsilon-anti-apoptotic kinase signaling complex protects human vascular endothelial cells against apoptosis through induction of Bcl-2.

21 January 2018

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Effects of thrombin on interactions between beta3-integrins and extracellular matrix in platelets and vascular cells

21 January 2018

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Integrins and angiogenesis

21 January 2018

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On the mechanism of thrombin-induced angiogenesis: involvement of alphavbeta3-integrin

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Role of thrombin in angiogenesis and tumor progression

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Thrombin (PAR-1)-induced proliferation in astrocytes via MAPK involves multiple signaling pathways

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Comparison of the effects of prostacyclin (PGI2), prostaglandin E1 and D2 on platelet aggregation in different species

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21 January 2018

Identifiers

DOI

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14 May 2018

PubMed ID

18367587

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14 May 2018