Vaccination of fiber-modified adenovirus-transfected dendritic cells to express HER-2/neu stimulates efficient HER-2/neu-specific humoral and CTL responses and reduces breast carcinogenesis in transgenic mice. (Q53482870)

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scientific article published on 18 April 2008

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English	Vaccination of fiber-modified adenovirus-transfected dendritic cells to express HER-2/neu stimulates efficient HER-2/neu-specific humoral and CTL responses and reduces breast carcinogenesis in transgenic mice.	scientific article published on 18 April 2008

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

14 May 2018

http://europepmc.org/abstract/MED/18421311

Vaccination of fiber-modified adenovirus-transfected dendritic cells to express HER-2/neu stimulates efficient HER-2/neu-specific humoral and CTL responses and reduces breast carcinogenesis in transgenic mice. (English)

1 reference

Europe PubMed Central

PubMed publication ID

14 May 2018

http://europepmc.org/abstract/MED/18421311

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based on heuristic

inferred from title

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based on heuristic

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author name string

S Sas

1

1 reference

Europe PubMed Central

PubMed publication ID

14 May 2018

http://europepmc.org/abstract/MED/18421311

T Chan

2

1 reference

Europe PubMed Central

PubMed publication ID

14 May 2018

http://europepmc.org/abstract/MED/18421311

A Sami

3

1 reference

Europe PubMed Central

PubMed publication ID

14 May 2018

http://europepmc.org/abstract/MED/18421311

A El-Gayed

4

1 reference

Europe PubMed Central

PubMed publication ID

14 May 2018

http://europepmc.org/abstract/MED/18421311

J Xiang

5

1 reference

Europe PubMed Central

PubMed publication ID

14 May 2018

http://europepmc.org/abstract/MED/18421311

publication date

18 April 2008

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Europe PubMed Central

PubMed publication ID

14 May 2018

http://europepmc.org/abstract/MED/18421311

Cancer Gene Therapy

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Europe PubMed Central

PubMed publication ID

14 May 2018

http://europepmc.org/abstract/MED/18421311

15

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Europe PubMed Central

PubMed publication ID

14 May 2018

http://europepmc.org/abstract/MED/18421311

10

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Europe PubMed Central

PubMed publication ID

14 May 2018

http://europepmc.org/abstract/MED/18421311

655-666

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Europe PubMed Central

PubMed publication ID

14 May 2018

http://europepmc.org/abstract/MED/18421311

https://scigraph.springernature.com/pub.10.1038/cgt.2008.18

0 references

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21 January 2018

Breast and ovarian cancer-specific cytotoxic T lymphocytes recognize the same HER2/neu-derived peptide

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21 January 2018

Dendritic cells and the control of immunity

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The cell biology of antigen presentation in dendritic cells.

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Dendritic cells in antitumor immune responses. II. Dendritic cells grown from bone marrow precursors, but not mature DC from tumor-bearing mice, are effective antigen carriers in the therapy of established tumors.

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Idiotype-pulsed dendritic cell vaccination for B-cell lymphoma: clinical and immune responses in 35 patients

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Identification and characterization of the immunodominant rat HER-2/neu MHC class I epitope presented by spontaneous mammary tumors from HER-2/neu-transgenic mice

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The life span of major histocompatibility complex-peptide complexes influences the efficiency of presentation and immunogenicity of two class I-restricted cytotoxic T lymphocyte epitopes in the Epstein-Barr virus nuclear antigen 4

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In vivo CTL induction with point-substituted ovalbumin peptides: immunogenicity correlates with peptide-induced MHC class I stability

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Dendritic cells pulsed with glioma lysates induce immunity against syngeneic intracranial gliomas and increase survival of tumor-bearing mice.

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Th1 and Th2 cell clones to a poorly immunogenic tumor antigen initiate CD8+ T cell-dependent tumor eradication in vivo

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Induction of ErbB-2/neu-specific protective and therapeutic antitumor immunity using genetically modified dendritic cells: enhanced efficacy by cotransduction of gene encoding IL-12.

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The generation of both T killer and Th cell clones specific for the tumor-associated antigen HER2 using retrovirally transduced dendritic cells

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Targeting HER-2/neu in early breast cancer development using dendritic cells with staged interleukin-12 burst secretion.

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Dendritic cells can be rapidly expanded ex vivo and safely administered in patients with metastatic breast cancer

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Vaccination by genetically modified dendritic cells expressing a truncated neu oncogene prevents development of breast cancer in transgenic mice

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HER-2/neu-gene engineered dendritic cell vaccine stimulates stronger HER-2/neu-specific immune responses compared to DNA vaccination

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Efficient gene delivery into dendritic cells by fiber-mutant adenovirus vectors

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Gene transduction efficiency and maturation status in mouse bone marrow-derived dendritic cells infected with conventional or RGD fiber-mutant adenovirus vectors

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An adenoviral vector containing an arg-gly-asp (RGD) motif in the fiber knob enhances protein product levels from transgenes refractory to expression

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A simplified system for generating recombinant adenoviruses

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Conditionally replication-competent adenoviral vectors with enhanced infectivity for use in gene therapy of melanoma

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Recruitment of latent pools of high-avidity CD8(+) T cells to the antitumor immune response

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A new dynamic model of CD8+ T effector cell responses via CD4+ T helper-antigen-presenting cells

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Intratumoral administration of immature dendritic cells following the adenovirus vector encoding CD40 ligand elicits significant regression of established myeloma

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Regression of engineered tumor cells secreting cytokines is related to a shift in host cytokine profile from type 2 to type 1.

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Progress and potential for gene-based medicines

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Gene therapy. Second child in French trial is found to have leukemia

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Isolation of a common receptor for Coxsackie B viruses and adenoviruses 2 and 5

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Integrins alpha v beta 3 and alpha v beta 5 promote adenovirus internalization but not virus attachment

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Cell receptors involved in adenovirus entry

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Maturation of dendritic cells infected by recombinant adenovirus can be delayed without impact on transgene expression

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21 January 2018

Expression of the neu protooncogene in the mammary epithelium of transgenic mice induces metastatic disease

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21 January 2018

Prevention of spontaneous neu-expressing mammary tumor development in mice transgenic for rat proto-neu by DNA vaccination.

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21 January 2018

Anti-HER-2/neu immune responses are induced before the development of clinical tumors but declined following tumorigenesis in HER-2/neu transgenic mice

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21 January 2018

Peptides determine the lifespan of MHC class II molecules in the antigen-presenting cell

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21 January 2018

neu/erbB-2 amplification identifies a poor-prognosis group of women with node-negative breast cancer. Toronto Breast Cancer Study Group

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7 January 2021

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High-titer HER-2/neu protein-specific antibody can be detected in patients with early-stage breast cancer

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7 January 2021

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Flt3 ligand as a vaccine adjuvant in association with HER-2/neu peptide-based vaccines in patients with HER-2/neu-overexpressing cancers

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Presentation of a major histocompatibility complex class 1-binding peptide by monocyte-derived dendritic cells incorporating hydrophobized polysaccharide-truncated HER2 protein complex: implications for a polyvalent immuno-cell therapy

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Vaccination of advanced hepatocellular carcinoma patients with tumor lysate-pulsed dendritic cells: a clinical trial

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Enhanced HER-2/neu-specific antitumor immunity by cotransduction of mouse dendritic cells with two genes encoding HER-2/neu and alpha tumor necrosis factor

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Adenovirus-mediated TNF-alpha gene transfer induces significant tumor regression in mice

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AdEasy system made easier by selecting the viral backbone plasmid preceding homologous recombination

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Identifiers

10.1038/CGT.2008.18

1 reference

Europe PubMed Central

PubMed publication ID

14 May 2018

http://europepmc.org/abstract/MED/18421311

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

14 May 2018

http://europepmc.org/abstract/MED/18421311

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