Mechanistic insights into chemopreventive effects of phenethyl isothiocyanate in N-nitrosobis(2-oxopropyl)amine-treated hamsters. (Q53437017)

14 May 2018

title

Mechanistic insights into chemopreventive effects of phenethyl isothiocyanate in N-nitrosobis(2-oxopropyl)amine-treated hamsters. (English)

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14 May 2018

author name string

A Nishikawa

1

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14 May 2018

I S Lee

2

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14 May 2018

C Uneyama

3

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14 May 2018

F Furukawa

4

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14 May 2018

H C Kim

5

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14 May 2018

K Kasahara

6

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14 May 2018

N Huh

7

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14 May 2018

M Takahashi

8

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14 May 2018

publication date

1 December 1997

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14 May 2018

number of pages

6

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Japanese Journal of Cancer Research

inferred from page(s)

published in

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14 May 2018

volume

88

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14 May 2018

issue

12

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14 May 2018

page(s)

1137-1142

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14 May 2018

Inhibition of N-nitrosodimethylamine demethylase in rat and human liver microsomes by isothiocyanates and their glutathione, L-cysteine, and N-acetyl-L-cysteine conjugates

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Metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) by human cytochrome P450 1A2 and its inhibition by phenethyl isothiocyanate.

22 May 2018

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The significance of DNA damage, its repair and cell proliferation during carcinogen treatment in the initiation of pancreatic cancer in the hamster model.

22 May 2018

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Cytochrome P-450 enzymes as targets for chemoprevention against chemical carcinogenesis and toxicity: opportunities and limitations.

22 May 2018

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Anticarcinogenic activities of organic isothiocyanates: chemistry and mechanisms

22 May 2018

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Structure-activity relationships of isothiocyanates as mechanism-based inhibitors of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumorigenesis in A/J mice.

22 May 2018

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Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

22 May 2018

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Mutagenic activation of carcinogenic N-nitrosopropylamines by liver S9 fractions from mice, rats and hamsters: evidence for a cytochrome P-450-dependent reaction

22 May 2018

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Effects of aromatic isothiocyanates on tumorigenicity, O6-methylguanine formation, and metabolism of the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in A/J mouse lung.

22 May 2018

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Cell specific DNA alkylation in target and non-target organs of N-nitrosobis(2-oxopropyl)amine-induced carcinogenesis in hamster and rat.

22 May 2018

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Inhibitory effects of phenethyl isothiocyanate on N-nitrosobenzylmethylamine carcinogenesis in the rat esophagus

22 May 2018

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Structure-activity relationships for inhibition of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone lung tumorigenesis by arylalkyl isothiocyanates in A/J mice.

22 May 2018

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Metabolic activation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone as measured by DNA alkylation in vitro and its inhibition by isothiocyanates

22 May 2018

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Matabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) by cytochrome P450IIB1 in a reconstituted system

22 May 2018

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Alkylation of rodent tissue DNA induced by N-nitrosobis(2-hydroxypropyl)amine

22 May 2018

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A major inducer of anticarcinogenic protective enzymes from broccoli: isolation and elucidation of structure

22 May 2018

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Effects of caffeine, nicotine, ethanol and sodium selenite on pancreatic carcinogenesis in hamsters after initiation with N-nitrosobis(2-oxopropyl)amine

22 May 2018

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A potent pancreatic carcinogen in Syrian hamsters: N-nitrosobis(2-oxopropyl)amine

22 May 2018

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Inhibition of Carcinogenic Effects of Polycyclic Hydrocarbons by Benzyl Isothiocyanate and Related Compounds2

22 May 2018

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Model Studies in Tobacco Carcinogenesis with the Syrian Golden Hamster1

22 May 2018

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Chemopreventive effects of 3-phenylpropyl isothiocyanate on hamster lung tumorigenesis initiated with N-nitrosobis(2-oxopropyl)amine.

22 May 2018

1 reference

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Structure-activity relationships of arylalkyl isothiocyanates for the inhibition of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone metabolism and the modulation of xenobiotic-metabolizing enzymes in rats and mice.

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5921340

Mechanisms of inhibition of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone bioactivation in mouse by dietary phenethyl isothiocyanate.

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5921340

Effect of tobacco smoke condensate on the metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone by adult and fetal hamster microsomes.

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5921340

Effects of isothiocyanate alkyl chain-length on hamster liver cytochrome P-450 activity.

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5921340

Effects of cigarette smoke on N-nitrosobis(2-oxopropyl)amine-induced pancreatic and respiratory tumorigenesis in hamsters.

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5921340

Conjugations with glutathione. Distribution of glutathione S-aryltransferase in vertebrate species

13 August 2018

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Inhibition of rat liver cytochrome P450 isozymes by isothiocyanates and their conjugates: a structure-activity relationship study

13 August 2018

1 reference

12 December 2020

Isothiocyanates inhibit cell cycle progression of HeLa cells at G2/M phase

1 reference

12 December 2020

Effects of phenethyl isothiocyanate, a carcinogenesis inhibitor, on xenobiotic-metabolizing enzymes and nitrosamine metabolism in rats

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12 December 2020

Phenethyl isothiocyanate, a natural chemopreventive agent, activates c-Jun N-terminal kinase 1

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12 December 2020

New potential chemopreventive agents for lung carcinogenesis of tobacco-specific nitrosamine

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12 December 2020

Effects of various prostaglandin synthesis inhibitors on pancreatic carcinogenesis in hamsters after initiation with N-nitrosobis(2-oxopropyl)amine

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12 December 2020

Inhibition of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced DNA adduct formation and tumorigenicity in the lung of F344 rats by dietary phenethyl isothiocyanate

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12 December 2020

A fluorometric method for determination of oxidized and reduced glutathione in tissues

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12 December 2020

Glutathione S-transferase subunit induction patterns of Brussels sprouts, allyl isothiocyanate and goitrin in rat liver and small intestinal mucosa: a new approach for the identification of inducing xenobiotics

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12 December 2020

Chemopreventive effects of phenethyl isothiocyanate on lung and pancreatic tumorigenesis in N-nitrosobis(2-oxopropyl)amine-treated hamsters

1 reference

12 December 2020

1 reference

12 December 2020

Screening of potential chemopreventive agents using biochemical markers of carcinogenesis

1 reference

12 December 2020

10.1111/J.1349-7006.1997.TB00341.X

Identifiers

DOI

1 reference

14 May 2018

PMCID

5921340

1 reference

14 May 2018

PubMed ID

9473730

1 reference

14 May 2018