Phospholipase D and mTORC1: nutrients are what bring them together. (Q53176923)

12 May 2018

title

Phospholipase D and mTORC1: nutrients are what bring them together. (English)

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12 May 2018

author name string

Brian M Wiczer

series ordinal

1

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12 May 2018

George Thomas

series ordinal

2

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12 May 2018

publication date

27 March 2012

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12 May 2018

published in

Science Signaling

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12 May 2018

volume

5

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12 May 2018

issue

217

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12 May 2018

page(s)

pe13

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12 May 2018

Overweight, obesity and cancer: epidemiological evidence and proposed mechanisms

cites work

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https://api.crossref.org/works/10.1126%2FSCISIGNAL.2003019

mTOR: from growth signal integration to cancer, diabetes and ageing

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2003019

mTORC1-mediated cell proliferation, but not cell growth, controlled by the 4E-BPs

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2003019

mTORC1 senses lysosomal amino acids through an inside-out mechanism that requires the vacuolar H(+)-ATPase

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2003019

Amino acid signaling in TOR activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2003019

Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2003019

Glycolytic flux signals to mTOR through glyceraldehyde-3-phosphate dehydrogenase-mediated regulation of Rheb

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2003019

Phospholipase D1 is an effector of Rheb in the mTOR pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2003019

The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2003019

Regulation of TORC1 by Rag GTPases in nutrient response

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2003019

Amino acids activate mTOR complex 1 via Ca2+/CaM signaling to hVps34.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2003019

Amino acids mediate mTOR/raptor signaling through activation of class 3 phosphatidylinositol 3OH-kinase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2003019

Rheb promotes cell growth as a component of the insulin/TOR signalling network

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2003019

Phosphatidic acid-mediated mitogenic activation of mTOR signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2003019

Class III PI-3-kinase activates phospholipase D in an amino acid-sensing mTORC1 pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2003019

Phospholipase D mediates nutrient input to mammalian target of rapamycin complex 1 (mTORC1).

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2003019

Functional association between Arf and RalA in active phospholipase D complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2003019

Activation of phospholipase D1 by direct interaction with ADP-ribosylation factor 1 and RalA

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2003019

RalA interacts directly with the Arf-responsive, PIP2-dependent phospholipase D1

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2003019

Involvement of Ral GTPase in v-Src-induced phospholipase D activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2003019

Rheb is an essential regulator of S6K in controlling cell growth in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2003019

Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2003019

RalA functions as an indispensable signal mediator for the nutrient-sensing system

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2003019

The regulation of phospholipase D by inositol phospholipids and small GTPases

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2003019

Colocalization of phospholipase D1 and GTP-binding-defective mutant of ADP-ribosylation factor 6 to endosomes and lysosomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2003019

Aldolase directly interacts with ARNO and modulates cell morphology and acidic vesicle distribution

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2003019

V-ATPase interacts with ARNO and Arf6 in early endosomes and regulates the protein degradative pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2003019

Mechanism of membrane binding of the phospholipase D1 PX domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2003019

Gene silencing reveals a specific function of hVps34 phosphatidylinositol 3-kinase in late versus early endosomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2003019

Class II phosphoinositide 3-kinase defines a novel signaling pathway in cell migration.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2003019

hVps34 is a nutrient-regulated lipid kinase required for activation of p70 S6 kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2003019

Disruption of the mouse mTOR gene leads to early postimplantation lethality and prohibits embryonic stem cell development

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2003019

The mammalian class 3 PI3K (PIK3C3) is required for early embryogenesis and cell proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2003019

The class III PI(3)K Vps34 promotes autophagy and endocytosis but not TOR signaling in Drosophila.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2003019

mTOR signaling: PLD takes center stage

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2003019

Identification of pathways regulating cell size and cell-cycle progression by RNAi

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2003019

Class III PI3K Vps34 plays an essential role in autophagy and in heart and liver function

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2003019

Amino acid transport regulates blastocyst implantation

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2003019

Exogenous amino acids regulate trophectoderm differentiation in the mouse blastocyst through an mTOR-dependent pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2003019

Impaired alpha(IIb)beta(3) integrin activation and shear-dependent thrombus formation in mice lacking phospholipase D1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2003019

Phosphatidic acid activates mammalian target of rapamycin complex 1 (mTORC1) kinase by displacing FK506 binding protein 38 (FKBP38) and exerting an allosteric effect

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2003019

PLD2 forms a functional complex with mTOR/raptor to transduce mitogenic signals

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2003019

Regulation of mTORC1 and mTORC2 complex assembly by phosphatidic acid: competition with rapamycin

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2003019

10.1126/SCISIGNAL.2003019

21 January 2018

Identifiers

DOI

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12 May 2018

PubMed ID

22457329

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12 May 2018