From oncogene to tumor suppressor: the dual role of Myc in leukemia. (Q53173608)

12 May 2018

title

From oncogene to tumor suppressor: the dual role of Myc in leukemia. (English)

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12 May 2018

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12 May 2018

Salvador Aznar Benitah

object named as

Salvador Aznar Benitah

series ordinal

2

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author name string

Iris Uribesalgo

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1

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12 May 2018

publication date

1 May 2012

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12 May 2018

number of pages

8

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based on heuristic

inferred from page(s)

published in

Cell Cycle

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12 May 2018

volume

11

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issue

9

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12 May 2018

page(s)

1757-1764

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12 May 2018

Analysis of genomic targets reveals complex functions of MYC.

cites work

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Sequence-specific DNA binding by the c-Myc protein

21 January 2018

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Max: a helix-loop-helix zipper protein that forms a sequence-specific DNA-binding complex with Myc

21 January 2018

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c-Myc target genes involved in cell growth, apoptosis, and metabolism

21 January 2018

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TGFbeta influences Myc, Miz-1 and Smad to control the CDK inhibitor p15INK4b

21 January 2018

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Repression of p15INK4b expression by Myc through association with Miz-1

21 January 2018

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Down-regulation of LFA-1 adhesion receptors by C-myc oncogene in human B lymphoblastoid cells

21 January 2018

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Negative regulation of the mammalian UV response by Myc through association with Miz-1

21 January 2018

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Repression of transcription of the p27(Kip1) cyclin-dependent kinase inhibitor gene by c-Myc.

21 January 2018

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N-myc is essential during neurogenesis for the rapid expansion of progenitor cell populations and the inhibition of neuronal differentiation

21 January 2018

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c-Myc activation in transgenic mouse epidermis results in mobilization of stem cells and differentiation of their progeny

21 January 2018

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Deregulated expression of c-Myc depletes epidermal stem cells

21 January 2018

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MYC in mammalian epidermis: how can an oncogene stimulate differentiation?

21 January 2018

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Myc's secret life without Max.

21 January 2018

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Max-independent functions of Myc in Drosophila melanogaster

21 January 2018

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Transcriptional regulation and transformation by Myc proteins

21 January 2018

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Direct role for Myc in transcription initiation mediated by interactions with TFII-I

21 January 2018

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Inhibition of transcriptional regulator Yin-Yang-1 by association with c-Myc

21 January 2018

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Myc represses the p21(WAF1/CIP1) promoter and interacts with Sp1/Sp3.

21 January 2018

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Negative control of the Myc protein by the stress-responsive kinase Pak2

21 January 2018

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Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor

21 January 2018

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A transcriptional co-repressor that interacts with nuclear hormone receptors

21 January 2018

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A CBP integrator complex mediates transcriptional activation and AP-1 inhibition by nuclear receptors

21 January 2018

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Role of CBP/P300 in nuclear receptor signalling

21 January 2018

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A complex containing N-CoR, mSin3 and histone deacetylase mediates transcriptional repression

21 January 2018

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Myc-mediated transcriptional repression by recruitment of histone deacetylase.

21 January 2018

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Stimulation of c-MYC transcriptional activity and acetylation by recruitment of the cofactor CBP.

21 January 2018

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The Yin and Yang functions of the Myc oncoprotein in cancer development and as targets for therapy

21 January 2018

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Inhibition of cell differentiation: a critical mechanism for MYC-mediated carcinogenesis?

21 January 2018

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E-box-independent regulation of transcription and differentiation by MYC.

21 January 2018

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c-Myc-mediated expression of nucleophosmin/B23 decreases during retinoic acid-induced differentiation of human leukemia HL-60 cells.

21 January 2018

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Interaction between p21-activated protein kinase and Rac during differentiation of HL-60 human promyelocytic leukemia cell induced by all-trans-retinoic acid

21 January 2018

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Actomyosin-mediated cellular tension drives increased tissue stiffness and β-catenin activation to induce epidermal hyperplasia and tumor growth

21 January 2018

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Actin dynamics control SRF activity by regulation of its coactivator MAL

21 January 2018

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Nuclear actin regulates dynamic subcellular localization and activity of the SRF cofactor MAL.

21 January 2018

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21 January 2018

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Actin and serum response factor transduce physical cues from the microenvironment to regulate epidermal stem cell fate decisions.

21 January 2018

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Shape-induced terminal differentiation of human epidermal stem cells requires p38 and is regulated by histone acetylation

21 January 2018

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p21-activated protein kinase gamma-PAK is translocated and activated in response to hyperosmolarity. Implication of Cdc42 and phosphoinositide 3-kinase in a two-step mechanism for gamma-PAK activation

21 January 2018

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Cytostatic p21 G protein-activated protein kinase gamma-PAK

21 January 2018

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p38 MAP kinases: beyond the stress response

21 January 2018

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JAK2 phosphorylates histone H3Y41 and excludes HP1alpha from chromatin

21 January 2018

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Transcriptional induction of MKP-1 in response to stress is associated with histone H3 phosphorylation-acetylation

21 January 2018

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MSK2 and MSK1 mediate the mitogen- and stress-induced phosphorylation of histone H3 and HMG-14

21 January 2018

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p38 pathway targets SWI-SNF chromatin-remodeling complex to muscle-specific loci

21 January 2018

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Epigenetic histone modification and cardiovascular lineage programming in mouse embryonic stem cells exposed to laminar shear stress

21 January 2018

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Intracellular bacteria differentially regulated endothelial cytokine release by MAPK-dependent histone modification

21 January 2018

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Induction of Progesterone Target Genes Requires Activation of Erk and Msk Kinases and Phosphorylation of Histone H3

21 January 2018

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Dynamic changes in histone H3 phosphoacetylation during early embryonic stem cell differentiation are directly mediated by mitogen- and stress-activated protein kinase 1 via activation of MAPK pathways.

21 January 2018

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p21-activated kinase 1 interacts with and phosphorylates histone H3 in breast cancer cells

21 January 2018

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Stem cell depletion through epidermal deletion of Rac1.

21 January 2018

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Genome-wide mapping of Myc binding and gene regulation in serum-stimulated fibroblasts.

21 January 2018

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Myc regulates keratinocyte adhesion and differentiation via complex formation with Miz1

21 January 2018

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The RNA methyltransferase Misu (NSun2) mediates Myc-induced proliferation and is upregulated in tumors

21 January 2018

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The opposing transcriptional functions of Sin3a and c-Myc are required to maintain tissue homeostasis

21 January 2018

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Lrig1 expression defines a distinct multipotent stem cell population in mammalian epidermis

21 January 2018

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c-Myc controls the balance between hematopoietic stem cell self-renewal and differentiation

21 January 2018

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Rho GTPases and regulation of hematopoietic stem cell localization

21 January 2018

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Myc-nick: a cytoplasmic cleavage product of Myc that promotes alpha-tubulin acetylation and cell differentiation

21 January 2018

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Activation of RXR and RAR signaling promotes myogenic differentiation of myoblastic C2C12 cells

21 January 2018

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Differentiation therapy of leukemia: 3 decades of development

21 January 2018

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Methyltransferase recruitment and DNA hypermethylation of target promoters by an oncogenic transcription factor

21 January 2018

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Chromatin modifying activity of leukaemia associated fusion proteins

21 January 2018

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Dynamics of epigenetic modifications in leukemia

21 January 2018

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RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia

21 January 2018

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Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia

21 January 2018

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BET bromodomain inhibition as a therapeutic strategy to target c-Myc

21 January 2018

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Targeting MYC dependence in cancer by inhibiting BET bromodomains

21 January 2018

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Translocation (2;3) in hematologic malignancies

21 January 2018

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Expression of the ETS2 and transferrin receptor genes in Philadelphia-positive chronic myeloid leukemia patients with a reciprocal t(3;21)

21 January 2018

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Primary cutaneous neuroendocrine tumors. Diagnostic use of cytogenetic and MIC2 analysis

21 January 2018

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Design and properties of a Myc derivative that efficiently homodimerizes

21 January 2018

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Modelling Myc inhibition as a cancer therapy

21 January 2018

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Oncogenic activity of the c-Myc protein requires dimerization with Max.

21 January 2018

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AML1-ETO expression is directly involved in the development of acute myeloid leukemia in the presence of additional mutations

21 January 2018

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Role of the polycomb repressive complex 2 in acute promyelocytic leukemia

21 January 2018

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A cell initiating human acute myeloid leukaemia after transplantation into SCID mice

21 January 2018

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Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell

21 January 2018

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p21-activated Protein Kinase γ-PAK Is Activated by Ionizing Radiation and Other DNA-damaging Agents

21 January 2018

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More than just proliferation: Myc function in stem cells

21 January 2018

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Myc suppression of the p21 Cip1 Cdk inhibitor influences the outcome of the p53 response to DNA damage

21 January 2018

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21 January 2018

Identifiers

DOI

10.4161/CC.19883

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12 May 2018

PubMed ID

22510570

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12 May 2018