Impact of NOTCH1/FBXW7 mutations on outcome in pediatric T-cell acute lymphoblastic leukemia patients treated on the MRC UKALL 2003 trial. (Q53155926)

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8 February 2020

title

Impact of NOTCH1/FBXW7 mutations on outcome in pediatric T-cell acute lymphoblastic leukemia patients treated on the MRC UKALL 2003 trial (English)

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8 February 2020

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lymphoblastic leukemia

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T-cell acute lymphoblastic leukemia

inferred from title

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10

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Marc Mansour

3

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11

D C Linch

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R E Gale

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author name string

S Jenkinson

1

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K Koo

2

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N Goulden

4

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A Vora

5

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C Mitchell

6

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R Wade

7

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S Richards

8

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J Hancock

9

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publication date

3 July 2012

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volume

27

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issue

1

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page(s)

41-47

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https://scigraph.springernature.com/pub.10.1038/leu.2012.176

8 February 2020

exact match

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Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia

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NOTCH1 and/or FBXW7 mutations predict for initial good prednisone response but not for improved outcome in pediatric T-cell acute lymphoblastic leukemia patients treated on DCOG or COALL protocols

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Activating NOTCH1 mutations predict favorable early treatment response and long-term outcome in childhood precursor T-cell lymphoblastic leukemia.

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NOTCH1 and FBXW7 mutations have a favorable impact on early response to treatment, but not on outcome, in children with T-cell acute lymphoblastic leukemia (T-ALL) treated on EORTC trials 58881 and 58951.

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Impact of complex NOTCH1 mutations on survival in paediatric T-cell leukaemia.

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Notch subunit heterodimerization and prevention of ligand-independent proteolytic activation depend, respectively, on a novel domain and the LNR repeats

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Functional interaction between SEL-10, an F-box protein, and the nuclear form of activated Notch1 receptor

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NOTCH1 extracellular juxtamembrane expansion mutations in T-ALL.

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Structure of the Notch1-negative regulatory region: implications for normal activation and pathogenic signaling in T-ALL

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Leukemia-associated NOTCH1 alleles are weak tumor initiators but accelerate K-ras-initiated leukemia

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7 January 2021

The tumor suppressor gene hCDC4 is frequently mutated in human T-cell acute lymphoblastic leukemia with functional consequences for Notch signaling.

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7 January 2021

The SCFFBW7 ubiquitin ligase complex as a tumor suppressor in T cell leukemia

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The favorable effect of activating NOTCH1 receptor mutations on long-term outcome in T-ALL patients treated on the ALL-BFM 2000 protocol can be separated from FBXW7 loss of function

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FBW7 mutations in leukemic cells mediate NOTCH pathway activation and resistance to gamma-secretase inhibitors

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Sequential mutations in Notch1, Fbxw7, and Tp53 in radiation-induced mouse thymic lymphomas

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NOTCH mutations as prognostic markers in T-ALL

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High-resolution genomic profiling of childhood T-ALL reveals frequent copy-number alterations affecting the TGF-beta and PI3K-AKT pathways and deletions at 6q15-16.1 as a genomic marker for unfavorable early treatment response.

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