Asymmetric processing of a substrate protein in sequential allosteric cycles of AAA+ nanomachines. (Q53127332)

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26 February 2020

title

Asymmetric processing of a substrate protein in sequential allosteric cycles of AAA+ nanomachines (English)

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26 February 2020

2

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26 February 2020

author name string

Andrea N Kravats

series ordinal

1

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26 February 2020

Ryan J Bucher

series ordinal

3

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26 February 2020

George Stan

series ordinal

4

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26 February 2020

language of work or name

English

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publication date

1 September 2013

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Journal of Chemical Physics

26 February 2020

published in

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volume

139

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issue

12

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page(s)

121921

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Posttranslational quality control: folding, refolding, and degrading proteins.

26 February 2020

cites work

1 reference

AAA+ proteins: have engine, will work

21 January 2018

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On helicases and other motor proteins

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AAA+ proteases: ATP-fueled machines of protein destruction

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Six-fold rotational symmetry of ClpQ, the E. coli homolog of the 20S proteasome, and its ATP-dependent activator, ClpY.

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AAA+ superfamily ATPases: common structure--diverse function

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Global unfolding of a substrate protein by the Hsp100 chaperone ClpA.

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The structures of HsIU and the ATP-dependent protease HsIU-HsIV

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Crystal and solution structures of an HslUV protease-chaperone complex

21 January 2018

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Protein binding and unfolding by the chaperone ClpA and degradation by the protease ClpAP.

21 January 2018

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Mutational studies on HslU and its docking mode with HslV

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Central pore residues mediate the p97/VCP activity required for ERAD

21 January 2018

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Characterization of a trap mutant of the AAA+ chaperone ClpB.

21 January 2018

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Pore loops of the AAA+ ClpX machine grip substrates to drive translocation and unfolding

21 January 2018

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Role of the processing pore of the ClpX AAA+ ATPase in the recognition and engagement of specific protein substrates

21 January 2018

1 reference

Nucleotide-dependent conformational changes in a protease-associated ATPase HsIU

21 January 2018

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Asymmetric interactions of ATP with the AAA+ ClpX6 unfoldase: allosteric control of a protein machine.

21 January 2018

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Rebuilt AAA + motors reveal operating principles for ATP-fuelled machines

21 January 2018

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Asymmetric nucleotide transactions of the HslUV protease.

21 January 2018

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Structures of asymmetric ClpX hexamers reveal nucleotide-dependent motions in a AAA+ protein-unfolding machine

21 January 2018

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Unfolding and translocation pathway of substrate protein controlled by structure in repetitive allosteric cycles of the ClpY ATPase

21 January 2018

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Coupling ATP utilization to protein remodeling by ClpB, a hexameric AAA+ protein

21 January 2018

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DnaK chaperone-dependent disaggregation by caseinolytic peptidase B (ClpB) mutants reveals functional overlap in the N-terminal domain and nucleotide-binding domain-1 pore tyrosine

21 January 2018

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Structure of the 26S proteasome with ATP-γS bound provides insights into the mechanism of nucleotide-dependent substrate translocation

21 January 2018

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Functional ATPase activity of p97/valosin-containing protein (VCP) is required for the quality control of endoplasmic reticulum in neuronally differentiated mammalian PC12 cells

21 January 2018

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D1 ring is stable and nucleotide-independent, whereas D2 ring undergoes major conformational changes during the ATPase cycle of p97-VCP.

21 January 2018

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Positive cooperativity of the p97 AAA ATPase is critical for essential functions

21 January 2018

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Hexamerization of p97-VCP is promoted by ATP binding to the D1 domain and required for ATPase and biological activities

21 January 2018

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Nucleotide dependent motion and mechanism of action of p97/VCP

21 January 2018

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ATP-binding sites in brain p97/VCP (valosin-containing protein), a multifunctional AAA ATPase

21 January 2018

1 reference

Improved structures of full-length p97, an AAA ATPase: implications for mechanisms of nucleotide-dependent conformational change

21 January 2018

1 reference

CHARMM: the biomolecular simulation program

21 January 2018

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Coupling between allosteric transitions in GroEL and assisted folding of a substrate protein

21 January 2018

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Single pilus motor forces exceed 100 pN.

21 January 2018

1 reference

Dynamics of allosteric transitions in GroEL.

21 January 2018

1 reference

An intersubunit signaling network coordinates ATP hydrolysis by m-AAA proteases

21 January 2018

1 reference

Single-molecule protein unfolding and translocation by an ATP-fueled proteolytic machine.

21 January 2018

1 reference

ClpX(P) generates mechanical force to unfold and translocate its protein substrates

21 January 2018

1 reference

High degree of coordination and division of labor among subunits in a homomeric ring ATPase

21 January 2018

1 reference

Analysis of nucleotide binding to P97 reveals the properties of a tandem AAA hexameric ATPase

21 January 2018

1 reference

Role of the GYVG pore motif of HslU ATPase in protein unfolding and translocation for degradation by HslV peptidase

21 January 2018

1 reference

Stepwise activity of ClpY (HslU) mutants in the processive degradation of Escherichia coli ClpYQ (HslUV) protease substrates

21 January 2018

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Torsional rigidity of single actin filaments and actin-actin bond breaking force under torsion measured directly by in vitro micromanipulation

21 January 2018

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Chaperonin-facilitated protein folding: optimization of rate and yield by an iterative annealing mechanism

21 January 2018

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Coupling between protein folding and allostery in the GroE chaperonin system

21 January 2018

1 reference

Weak intra-ring allosteric communications of the archaeal chaperonin thermosome revealed by normal mode analysis

21 January 2018

1 reference

Measuring how much work the chaperone GroEL can do.

21 January 2018

1 reference

Putting handcuffs on the chaperonin GroEL.

21 January 2018

1 reference

Interactions of subunit CCT3 in the yeast chaperonin CCT/TRiC with Q/N-rich proteins revealed by high-throughput microscopy analysis.

21 January 2018

1 reference

Identification of the TRiC/CCT substrate binding sites uncovers the function of subunit diversity in eukaryotic chaperonins

21 January 2018

1 reference

Computer simulations of the translocation and unfolding of a protein pulled mechanically through a pore

21 January 2018

1 reference

Prediction of the translocation kinetics of a protein from its mechanical properties

21 January 2018

1 reference

Anomalous dynamics of forced translocation

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.1063/1.4817410

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26 February 2020

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