ACAT-selective and nonselective DGAT1 inhibition: adrenocortical effects--a cross-species comparison. (Q53120025)

11 May 2018

title

ACAT-selective and nonselective DGAT1 inhibition: adrenocortical effects--a cross-species comparison. (English)

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11 May 2018

author name string

Jan Eike Floettmann

1

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11 May 2018

Linda K Buckett

2

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11 May 2018

Andrew V Turnbull

3

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11 May 2018

Tim Smith

4

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11 May 2018

Carina Hallberg

5

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11 May 2018

Alan Birch

6

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David Lees

7

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Huw B Jones

8

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language of work or name

English

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publication date

20 February 2013

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11 May 2018

published in

Toxicologic Pathology

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11 May 2018

volume

41

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11 May 2018

page(s)

941-950

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11 May 2018

issue

7

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11 May 2018

Discovery of a potent, selective, and orally efficacious pyrimidinooxazinyl bicyclooctaneacetic acid diacylglycerol acyltransferase-1 inhibitor

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ACAT1 deficiency increases cholesterol synthesis in mouse peritoneal macrophages

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Potential role of acyl-coenzyme A:cholesterol transferase (ACAT) Inhibitors as hypolipidemic and antiatherosclerosis drugs

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Identification, optimisation and in vivo evaluation of oxadiazole DGAT-1 inhibitors for the treatment of obesity and diabetes.

21 January 2018

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Disruption of the acyl-CoA:cholesterol acyltransferase gene in mice: evidence suggesting multiple cholesterol esterification enzymes in mammals

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ACAT2 is localized to hepatocytes and is the major cholesterol-esterifying enzyme in human liver

21 January 2018

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Hypolipidaemic properties of a potent and bioavailable alkylsulphinyl-diphenylimidazole ACAT inhibitor (RP 73163) in animals fed diets low in cholesterol

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Preclinical safety evaluation of avasimibe in beagle dogs: an ACAT inhibitor with minimal adrenal effects

21 January 2018

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The triacylglycerol synthesis enzyme DGAT1 also catalyzes the synthesis of diacylglycerols, waxes, and retinyl esters

21 January 2018

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Thematic review series: glycerolipids. DGAT enzymes and triacylglycerol biosynthesis

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Diacylglycerol acyltransferases: Potential roles as pharmacological targets

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Identifiers

DOI

10.1177/0192623313477753

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11 May 2018

PubMed ID

23427273

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11 May 2018