Unravelling the mechanism and significance of thrombin binding to platelet glycoprotein Ib. (Q53061821)

11 May 2018

title

Unravelling the mechanism and significance of thrombin binding to platelet glycoprotein Ib. (English)

1 reference

11 May 2018

author name string

Zaverio M Ruggeri

1

1 reference

11 May 2018

Alessandro Zarpellon

2

1 reference

11 May 2018

James R Roberts

3

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11 May 2018

Richard A Mc Clintock

4

1 reference

11 May 2018

Hua Jing

5

1 reference

11 May 2018

G Loredana Mendolicchio

6

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11 May 2018

publication date

12 October 2010

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11 May 2018

Thrombosis and Haemostasis

published in

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11 May 2018

volume

104

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11 May 2018

issue

5

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11 May 2018

page(s)

894-902

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11 May 2018

Biophysical investigation of GpIbalpha binding to thrombin anion binding exosite II.

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In vivo relevance for platelet glycoprotein Ibalpha residue Tyr276 in thrombus formation.

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22 May 2018

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Crystal structure of the GpIbalpha-thrombin complex essential for platelet aggregation

22 May 2018

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Modulation of alpha-thrombin function by distinct interactions with platelet glycoprotein Ibalpha

22 May 2018

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Interaction of the 268-282 region of glycoprotein Ibalpha with the heparin-binding site of thrombin inhibits the enzyme activation of factor VIII.

22 May 2018

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Structures of glycoprotein Ibalpha and its complex with von Willebrand factor A1 domain

22 May 2018

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22 May 2018

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Crystal structure of the platelet glycoprotein Ib(alpha) N-terminal domain reveals an unmasking mechanism for receptor activation

22 May 2018

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Platelet glycoprotein ibalpha is a counterreceptor for the leukocyte integrin Mac-1 (CD11b/CD18)

22 May 2018

1 reference

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Platelet glycoprotein Ib: a zinc-dependent binding protein for the heavy chain of high-molecular-weight kininogen

22 May 2018

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The glycoprotein Ib-IX-V complex is a platelet counterreceptor for P-selectin

22 May 2018

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A dual thrombin receptor system for platelet activation

22 May 2018

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Human kininogens regulate thrombin binding to platelets through the glycoprotein Ib-IX-V complex

22 May 2018

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Identification of three tyrosine residues of glycoprotein Ib alpha with distinct roles in von Willebrand factor and alpha-thrombin binding

22 May 2018

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The role of haemostatic mechanisms

22 May 2018

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Factor VIII procoagulant protein.

22 May 2018

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The glycocalicin portion of platelet glycoprotein Ib expresses both high and moderate affinity receptor sites for thrombin. A soluble radioreceptor assay for the interaction of thrombin with platelets

22 May 2018

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von Willebrand factor. A reduced and alkylated 52/48-kDa fragment beginning at amino acid residue 449 contains the domain interacting with platelet glycoprotein Ib.

22 May 2018

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Crystal structure of the thrombin-hirudin complex: a novel mode of serine protease inhibition

22 May 2018

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Glycoproteins V and Ib-IX form a noncovalent complex in the platelet membrane

22 May 2018

1 reference

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The thrombin high-affinity binding site on platelets is a negative regulator of thrombin-induced platelet activation. Structure-function studies using two mutant thrombins, Quick I and Quick II.

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3810535

Thrombin interaction with platelet glycoprotein Ib: effect of glycocalicin on thrombin specificity

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3810535

The refined 1.9-Å X-ray crystal structure of d-Phe-Pro-Arg chloromethylketone-inhibited human α-thrombin: Structure analysis, overall structure, electrostatic properties, detailed active-site geometry, and structure-function relationships

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3810535

Platelet physiology and abnormalities of platelet function (second of two parts).

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3810535

Thrombin Receptors of Human Platelets: Thrombin Binding and Antithrombin Properties of Glycoprotein I

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3810535

Platelet physiology and abnormalities of platelet function (first of two parts).

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3810535

Protein C supports platelet binding and activation under flow: role of glycoprotein Ib and apolipoprotein E receptor 2.

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3810535

Thrombin mutant W215A/E217A acts as a platelet GPIb antagonist.

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3810535

Leukocyte engagement of platelet glycoprotein Ibalpha via the integrin Mac-1 is critical for the biological response to vascular injury

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3810535

Comparison of sea turtle thrombocyte aggregation to human platelet aggregation in whole blood

13 August 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3810535

Factor XI interacts with the leucine-rich repeats of glycoprotein Ibalpha on the activated platelet

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3810535

Structural and functional mapping of the thrombin domain involved in the binding to the platelet glycoprotein Ib.

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3810535

Expression of human platelet glycoprotein Ib alpha in transgenic mice

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3810535

Identification of a Binding Site for Glycoprotein Ibα in the Apple 3 Domain of Factor XI

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3810535

Characteristics of the interaction between thrombin exosite 1 and the sequence 269-287 [correction of 269-297] of platelet glycoprotein Ibalpha

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3810535

Human factor XII binding to the glycoprotein Ib-IX-V complex inhibits thrombin-induced platelet aggregation

30 November 2018

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12 December 2020

The GPIb thrombin-binding site is essential for thrombin-induced platelet procoagulant activity

1 reference

12 December 2020

Platelet glycoprotein Ib alpha binds to thrombin anion-binding exosite II inducing allosteric changes in the activity of thrombin.

1 reference

12 December 2020

Platelet glycocalicin: a single receptor for platelet aggregation induced by thrombin or ristocetin

1 reference

12 December 2020

Studies with a murine monoclonal antibody that abolishes ristocetin-induced binding of von Willebrand factor to platelets: additional evidence in support of GPIb as a platelet receptor for von Willebrand factor

1 reference

12 December 2020

von Willebrand disease

1 reference

12 December 2020

Effect of the hirudin carboxy-terminal peptide 54-65 on the interaction of thrombin with platelets

1 reference

12 December 2020

Function of glycoprotein Ib alpha in platelet activation induced by alpha-thrombin

1 reference

12 December 2020

Localization and characterization of an alpha-thrombin-binding site on platelet glycoprotein Ib alpha

1 reference

12 December 2020

Thrombin interaction with platelet GpIB: role of the heparin binding domain

1 reference

12 December 2020

Dynamic Visualization of Thrombopoiesis Within Bone Marrow

1 reference

12 December 2020

The platelet high affinity binding site for thrombin mimics hirudin, modulates thrombin-induced platelet activation, and is distinct from the glycoprotein Ib-IX-V complex

1 reference

12 December 2020

Involvement of platelet glycoprotein Ib in platelet microparticle mediated neutrophil activation

1 reference

12 December 2020

Identifiers

DOI

10.1160/TH10-09-0578

1 reference

11 May 2018

PMCID

3810535

1 reference

11 May 2018

PubMed ID

20941453

1 reference

11 May 2018