Synthesis and biological evaluation of nitrated 7-, 8-, 9-, and 10-hydroxyindenoisoquinolines as potential dual topoisomerase I (Top1)-tyrosyl-DNA phosphodiesterase I (TDP1) inhibitors. (Q52956077)

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scientific article published on 26 March 2015

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English	Synthesis and biological evaluation of nitrated 7-, 8-, 9-, and 10-hydroxyindenoisoquinolines as potential dual topoisomerase I (Top1)-tyrosyl-DNA phosphodiesterase I (TDP1) inhibitors.	scientific article published on 26 March 2015

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scholarly article

1 reference

Europe PubMed Central

9 May 2018

http://europepmc.org/abstract/MED/25811317

Synthesis and biological evaluation of nitrated 7-, 8-, 9-, and 10-hydroxyindenoisoquinolines as potential dual topoisomerase I (Top1)-tyrosyl-DNA phosphodiesterase I (TDP1) inhibitors. (English)

1 reference

Europe PubMed Central

9 May 2018

http://europepmc.org/abstract/MED/25811317

5

object named as

Yves Pommier

1 reference

Europe PubMed Central

9 May 2018

author name string

Trung Xuan Nguyen

1

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Europe PubMed Central

9 May 2018

http://europepmc.org/abstract/MED/25811317

Monica Abdelmalak

2

1 reference

Europe PubMed Central

9 May 2018

http://europepmc.org/abstract/MED/25811317

Christophe Marchand

3

1 reference

Europe PubMed Central

9 May 2018

http://europepmc.org/abstract/MED/25811317

Keli Agama

4

1 reference

Europe PubMed Central

9 May 2018

http://europepmc.org/abstract/MED/25811317

Mark Cushman

6

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Europe PubMed Central

9 May 2018

http://europepmc.org/abstract/MED/25811317

language of work or name

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publication date

26 March 2015

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Europe PubMed Central

9 May 2018

http://europepmc.org/abstract/MED/25811317

Journal of Medicinal Chemistry

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Europe PubMed Central

9 May 2018

http://europepmc.org/abstract/MED/25811317

58

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Europe PubMed Central

9 May 2018

http://europepmc.org/abstract/MED/25811317

7

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Europe PubMed Central

9 May 2018

http://europepmc.org/abstract/MED/25811317

3188-3208

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Europe PubMed Central

9 May 2018

http://europepmc.org/abstract/MED/25811317

Elevation of topoisomerase I messenger RNA, protein, and catalytic activity in human tumors: demonstration of tumor-type specificity and implications for cancer chemotherapy

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https://pubmed.ncbi.nlm.nih.gov/25811317

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

DNA topoisomerases

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https://pubmed.ncbi.nlm.nih.gov/25811317

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A eukaryotic enzyme that can disjoin dead-end covalent complexes between DNA and type I topoisomerases

1 reference

https://pubmed.ncbi.nlm.nih.gov/25811317

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Induction of reversible complexes between eukaryotic DNA topoisomerase I and DNA-containing oxidative base damages. 7, 8-dihydro-8-oxoguanine and 5-hydroxycytosine

1 reference

https://pubmed.ncbi.nlm.nih.gov/25811317

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

DNA damage-induced cell cycle checkpoints and DNA strand break repair in development and tumorigenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/25811317

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pathways for repair of topoisomerase I covalent complexes in Saccharomyces cerevisiae

1 reference

https://pubmed.ncbi.nlm.nih.gov/25811317

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The tyrosyl-DNA phosphodiesterase Tdp1 is a member of the phospholipase D superfamily

1 reference

https://pubmed.ncbi.nlm.nih.gov/25811317

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Processing of nucleopeptides mimicking the topoisomerase I-DNA covalent complex by tyrosyl-DNA phosphodiesterase

1 reference

https://pubmed.ncbi.nlm.nih.gov/25811317

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mutation of TDP1, encoding a topoisomerase I-dependent DNA damage repair enzyme, in spinocerebellar ataxia with axonal neuropathy

1 reference

https://pubmed.ncbi.nlm.nih.gov/25811317

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insights into substrate binding and catalytic mechanism of human tyrosyl-DNA phosphodiesterase (Tdp1) from vanadate and tungstate-inhibited structures

1 reference

https://pubmed.ncbi.nlm.nih.gov/25811317

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synthesis of new 3-alkoxy-7-amino-4-chloro-isocoumarin derivatives as new beta-amyloid peptide production inhibitors and their activities on various classes of protease

1 reference

https://pubmed.ncbi.nlm.nih.gov/25811317

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Camptothecin: current perspectives

1 reference

https://pubmed.ncbi.nlm.nih.gov/25811317

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

TDP1 overexpression in human cells counteracts DNA damage mediated by topoisomerases I and II

1 reference

https://pubmed.ncbi.nlm.nih.gov/25811317

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cellular Topoisomerase I Inhibition and Antiproliferative Activity by MJ-III-65 (NSC 706744), an Indenoisoquinoline Topoisomerase I Poison

1 reference

https://pubmed.ncbi.nlm.nih.gov/25811317

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Deficiency in 3'-phosphoglycolate processing in human cells with a hereditary mutation in tyrosyl-DNA phosphodiesterase (TDP1)

1 reference

https://pubmed.ncbi.nlm.nih.gov/25811317

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of human tyrosyl-DNA phosphodiesterase by aminoglycoside antibiotics and ribosome inhibitors

1 reference

https://pubmed.ncbi.nlm.nih.gov/25811317

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Defective Mre11-dependent activation of Chk2 by ataxia telangiectasia mutated in colorectal carcinoma cells in response to replication-dependent DNA double strand breaks

1 reference

https://pubmed.ncbi.nlm.nih.gov/25811317

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Topoisomerase I inhibitors: camptothecins and beyond

1 reference

https://pubmed.ncbi.nlm.nih.gov/25811317

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A systematic study of nitrated indenoisoquinolines reveals a potent topoisomerase I inhibitor

1 reference

https://pubmed.ncbi.nlm.nih.gov/25811317

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Investigation of the lactam side chain length necessary for optimal indenoisoquinoline topoisomerase I inhibition and cytotoxicity in human cancer cell cultures

1 reference

https://pubmed.ncbi.nlm.nih.gov/25811317

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Novel high-throughput electrochemiluminescent assay for identification of human tyrosyl-DNA phosphodiesterase (Tdp1) inhibitors and characterization of furamidine (NSC 305831) as an inhibitor of Tdp1

1 reference

https://pubmed.ncbi.nlm.nih.gov/25811317

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Optimization of the indenone ring of indenoisoquinoline topoisomerase I inhibitors

1 reference

https://pubmed.ncbi.nlm.nih.gov/25811317

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nitrated indenoisoquinolines as topoisomerase I inhibitors: a systematic study and optimization

1 reference

https://pubmed.ncbi.nlm.nih.gov/25811317

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Novel indenoisoquinolines NSC 725776 and NSC 724998 produce persistent topoisomerase I cleavage complexes and overcome multidrug resistance

1 reference

https://pubmed.ncbi.nlm.nih.gov/25811317

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tyrosyl-DNA phosphodiesterase as a target for anticancer therapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/25811317

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

DNA cleavage assay for the identification of topoisomerase I inhibitors

1 reference

https://pubmed.ncbi.nlm.nih.gov/25811317

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of phosphotyrosine mimetic inhibitors of human tyrosyl-DNA phosphodiesterase I by a novel AlphaScreen high-throughput assay

1 reference

https://pubmed.ncbi.nlm.nih.gov/25811317

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The indenoisoquinoline noncamptothecin topoisomerase I inhibitors: update and perspectives

1 reference

https://pubmed.ncbi.nlm.nih.gov/25811317

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Topoisomerase I levels in the NCI-60 cancer cell line panel determined by validated ELISA and microarray analysis and correlation with indenoisoquinoline sensitivity

1 reference

https://pubmed.ncbi.nlm.nih.gov/25811317

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

4-Pregnen-21-ol-3,20-dione-21-(4-bromobenzenesulfonate) (NSC 88915) and related novel steroid derivatives as tyrosyl-DNA phosphodiesterase (Tdp1) inhibitors

1 reference

https://pubmed.ncbi.nlm.nih.gov/25811317

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibitors of human tyrosyl-DNA phospodiesterase (hTdp1) developed by virtual screening using ligand-based pharmacophores

1 reference

https://pubmed.ncbi.nlm.nih.gov/25811317

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

DNA topoisomerases and their poisoning by anticancer and antibacterial drugs

1 reference

https://pubmed.ncbi.nlm.nih.gov/25811317

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

7-azaindenoisoquinolines as topoisomerase I inhibitors and potential anticancer agents

1 reference

https://pubmed.ncbi.nlm.nih.gov/25811317

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tyrosyl-DNA Phosphodiesterase 1 (Tdp1) inhibitors

1 reference

https://pubmed.ncbi.nlm.nih.gov/25811317

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tyrosyl-DNA phosphodiesterase 1 (TDP1) repairs DNA damage induced by topoisomerases I and II and base alkylation in vertebrate cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/25811317

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tyrosyl-DNA phosphodiesterase 1 inhibitor from an anamorphic fungus

1 reference

https://pubmed.ncbi.nlm.nih.gov/25811317

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synthesis and biological evaluation of the first dual tyrosyl-DNA phosphodiesterase I (Tdp1)-topoisomerase I (Top1) inhibitors

1 reference

https://pubmed.ncbi.nlm.nih.gov/25811317

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CellMiner: a web-based suite of genomic and pharmacologic tools to explore transcript and drug patterns in the NCI-60 cell line set.

1 reference

https://pubmed.ncbi.nlm.nih.gov/25811317

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

5-Arylidenethioxothiazolidinones as inhibitors of tyrosyl-DNA phosphodiesterase I.

1 reference

https://pubmed.ncbi.nlm.nih.gov/25811317

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification, synthesis, and biological evaluation of metabolites of the experimental cancer treatment drugs indotecan (LMP400) and indimitecan (LMP776) and investigation of isomerically hydroxylated indenoisoquinoline analogues as topoisomerase I

1 reference

https://pubmed.ncbi.nlm.nih.gov/25811317

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synthesis and biological evaluation of indenoisoquinolines that inhibit both tyrosyl-DNA phosphodiesterase I (Tdp1) and topoisomerase I (Top1)

1 reference

https://pubmed.ncbi.nlm.nih.gov/25811317

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Design and synthesis of L- and D-phenylalanine derived rhodanines with novel C5-arylidenes as inhibitors of HCV NS5B polymerase

1 reference

https://pubmed.ncbi.nlm.nih.gov/25811317

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The synthesis and SAR study of phenylalanine-derived (Z)-5-arylmethylidene rhodanines as anti-methicillin-resistant Staphylococcus aureus (MRSA) compounds.

1 reference

https://pubmed.ncbi.nlm.nih.gov/25811317

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Design, synthesis, and biological evaluation of O-2-modified indenoisoquinolines as dual topoisomerase I-tyrosyl-DNA phosphodiesterase I inhibitors

1 reference

https://pubmed.ncbi.nlm.nih.gov/25811317

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Virtual screening using ligand-based pharmacophores for inhibitors of human tyrosyl-DNA phospodiesterase (hTdp1)

1 reference

https://pubmed.ncbi.nlm.nih.gov/25811317

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1021/ACS.JMEDCHEM.5B00136

1 reference

Europe PubMed Central

9 May 2018

http://europepmc.org/abstract/MED/25811317

1 reference

Europe PubMed Central

9 May 2018

http://europepmc.org/abstract/MED/25811317

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