Membrane-bound Klotho is not expressed endogenously in healthy or uraemic human vascular tissue. (Q52934731)

9 May 2018

title

Membrane-bound Klotho is not expressed endogenously in healthy or uraemic human vascular tissue. (English)

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9 May 2018

author name string

Rik Mencke

1

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9 May 2018

Geert Harms

2

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9 May 2018

Katarina Mirković

3

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9 May 2018

Joyce Struik

4

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9 May 2018

Joris Van Ark

5

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9 May 2018

Ellen Van Loon

6

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9 May 2018

Melissa Verkaik

7

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9 May 2018

Martin H De Borst

8

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9 May 2018

Clark J Zeebregts

9

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9 May 2018

Joost G Hoenderop

10

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9 May 2018

Marc G Vervloet

11

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9 May 2018

Jan-Luuk Hillebrands

12

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9 May 2018

NIGRAM Consortium

13

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9 May 2018

publication date

26 June 2015

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9 May 2018

published in

Cardiovascular Research

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9 May 2018

volume

108

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9 May 2018

issue

2

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9 May 2018

page(s)

220-231

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9 May 2018

Chronic kidney disease and the risks of death, cardiovascular events, and hospitalization

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1 reference

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Chronic kidney disease as a predictor of cardiovascular disease (from the Framingham Heart Study)

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Severely reduced production of klotho in human chronic renal failure kidney.

21 January 2018

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Klotho deficiency causes vascular calcification in chronic kidney disease

21 January 2018

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Serum levels of soluble secreted α-Klotho are decreased in the early stages of chronic kidney disease, making it a probable novel biomarker for early diagnosis

21 January 2018

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Mutation of the mouse klotho gene leads to a syndrome resembling ageing

21 January 2018

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Suppression of Klotho expression by protein-bound uremic toxins is associated with increased DNA methyltransferase expression and DNA hypermethylation.

21 January 2018

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Klotho is a substrate for alpha-, beta- and gamma-secretase

21 January 2018

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Secreted Klotho protein in sera and CSF: implication for post-translational cleavage in release of Klotho protein from cell membrane

21 January 2018

1 reference

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Insulin stimulates the cleavage and release of the extracellular domain of Klotho by ADAM10 and ADAM17

21 January 2018

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https://api.crossref.org/works/10.1093%2FCVR%2FCVV187

Identification of the human klotho gene and its two transcripts encoding membrane and secreted klotho protein

21 January 2018

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Suppression of aging in mice by the hormone Klotho

21 January 2018

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Establishment of sandwich ELISA for soluble alpha-Klotho measurement: Age-dependent change of soluble alpha-Klotho levels in healthy subjects

21 January 2018

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Plasma klotho and mortality risk in older community-dwelling adults

21 January 2018

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The beta-glucuronidase klotho hydrolyzes and activates the TRPV5 channel

21 January 2018

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Klotho: a novel phosphaturic substance acting as an autocrine enzyme in the renal proximal tubule

21 January 2018

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Klotho converts canonical FGF receptor into a specific receptor for FGF23

21 January 2018

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Regulation of fibroblast growth factor-23 signaling by klotho

21 January 2018

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Klotho, a gene related to a syndrome resembling human premature aging, functions in a negative regulatory circuit of vitamin D endocrine system

21 January 2018

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https://api.crossref.org/works/10.1093%2FCVR%2FCVV187

In vivo genetic evidence for klotho-dependent, fibroblast growth factor 23 (Fgf23) -mediated regulation of systemic phosphate homeostasis

21 January 2018

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Fibroblast growth factor 23 and cardiovascular mortality after kidney transplantation

21 January 2018

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Relationship between circulating FGF23 and total body atherosclerosis in the community

21 January 2018

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FGF-23 associates with death, cardiovascular events, and initiation of chronic dialysis

21 January 2018

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Fibroblast growth factor 23 and risks of mortality and end-stage renal disease in patients with chronic kidney disease

21 January 2018

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Improvement of multiple pathophysiological phenotypes of klotho (kl/kl) mice by adenovirus-mediated expression of the klotho gene

21 January 2018

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Initial FGF23-mediated signaling occurs in the distal convoluted tubule

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVV187

Expression of FGF23/KLOTHO system in human vascular tissue.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVV187

Early chronic kidney disease-mineral bone disorder stimulates vascular calcification

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVV187

Vascular Klotho deficiency potentiates the development of human artery calcification and mediates resistance to fibroblast growth factor 23.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVV187

A protective role for FGF-23 in local defence against disrupted arterial wall integrity?

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVV187

Fibroblast growth factor 23 accelerates phosphate-induced vascular calcification in the absence of Klotho deficiency.

21 January 2018

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https://api.crossref.org/works/10.1093%2FCVR%2FCVV187

Reduced Klotho is associated with the presence and severity of coronary artery disease.

21 January 2018

1 reference

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Arterial klotho expression and FGF23 effects on vascular calcification and function

21 January 2018

1 reference

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Vitamin D receptor agonists increase klotho and osteopontin while decreasing aortic calcification in mice with chronic kidney disease fed a high phosphate diet

21 January 2018

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Fibroblast growth factor 23 is not associated with and does not induce arterial calcification

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVV187

Circulating alpha-klotho levels are not disturbed in patients with type 2 diabetes with and without macrovascular disease in the absence of nephropathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVV187

The secreted Klotho protein restores phosphate retention and suppresses accelerated aging in Klotho mutant mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVV187

The impact of nephrectomy and renal transplantation on serum levels of soluble Klotho protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVV187

Cross talk between the renin-angiotensin-aldosterone system and vitamin D-FGF-23-klotho in chronic kidney disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVV187

FGF23 induces left ventricular hypertrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVV187

Parathyroid-specific deletion of Klotho unravels a novel calcineurin-dependent FGF23 signaling pathway that regulates PTH secretion

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVV187

Structure of the mouse klotho gene and its two transcripts encoding membrane and secreted protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVV187

In vivo klotho gene transfer ameliorates angiotensin II-induced renal damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVV187

Klotho gene delivery prevents the progression of spontaneous hypertension and renal damage

21 January 2018

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https://api.crossref.org/works/10.1093%2FCVR%2FCVV187

Klotho gene delivery suppresses Nox2 expression and attenuates oxidative stress in rat aortic smooth muscle cells via the cAMP-PKA pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVV187

Replicative senescence of vascular smooth muscle cells enhances the calcification through initiating the osteoblastic transition

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVV187

CKD-induced wingless/integration1 inhibitors and phosphorus cause the CKD-mineral and bone disorder

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVV187

FGF23 protein expression in coronary arteries is associated with impaired kidney function.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVV187

Differential expression and regulation of Klotho by paricalcitol in the kidney, parathyroid, and aorta of uremic rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVV187

21 January 2018

Identifiers

DOI

10.1093/CVR/CVV187

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9 May 2018

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9 May 2018