CSAHi study: Evaluation of multi-electrode array in combination with human iPS cell-derived cardiomyocytes to predict drug-induced QT prolongation and arrhythmia--effects of 7 reference compounds at 10 facilities. (Q52896173)

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scientific article published on 4 December 2015

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English	CSAHi study: Evaluation of multi-electrode array in combination with human iPS cell-derived cardiomyocytes to predict drug-induced QT prolongation and arrhythmia--effects of 7 reference compounds at 10 facilities.	scientific article published on 4 December 2015

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scholarly article

1 reference

Europe PubMed Central

9 May 2018

http://europepmc.org/abstract/MED/26657830

CSAHi study: Evaluation of multi-electrode array in combination with human iPS cell-derived cardiomyocytes to predict drug-induced QT prolongation and arrhythmia--effects of 7 reference compounds at 10 facilities. (English)

1 reference

Europe PubMed Central

9 May 2018

http://europepmc.org/abstract/MED/26657830

author name string

Takashi Kitaguchi

1

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9 May 2018

http://europepmc.org/abstract/MED/26657830

Yuta Moriyama

2

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http://europepmc.org/abstract/MED/26657830

Tomohiko Taniguchi

3

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Europe PubMed Central

9 May 2018

http://europepmc.org/abstract/MED/26657830

Atsuko Ojima

4

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Europe PubMed Central

9 May 2018

http://europepmc.org/abstract/MED/26657830

Hiroyuki Ando

5

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Europe PubMed Central

9 May 2018

http://europepmc.org/abstract/MED/26657830

Takaaki Uda

6

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9 May 2018

http://europepmc.org/abstract/MED/26657830

Koji Otabe

7

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Europe PubMed Central

9 May 2018

http://europepmc.org/abstract/MED/26657830

Masao Oguchi

8

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http://europepmc.org/abstract/MED/26657830

Shigekazu Shimizu

9

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http://europepmc.org/abstract/MED/26657830

Hiroyuki Saito

10

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http://europepmc.org/abstract/MED/26657830

Maya Morita

11

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http://europepmc.org/abstract/MED/26657830

Atsushi Toratani

12

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http://europepmc.org/abstract/MED/26657830

Mahoko Asayama

13

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Europe PubMed Central

9 May 2018

http://europepmc.org/abstract/MED/26657830

Wataru Yamamoto

14

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9 May 2018

http://europepmc.org/abstract/MED/26657830

Emi Matsumoto

15

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9 May 2018

http://europepmc.org/abstract/MED/26657830

Daisuke Saji

16

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http://europepmc.org/abstract/MED/26657830

Hiroki Ohnaka

17

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9 May 2018

http://europepmc.org/abstract/MED/26657830

Kohji Tanaka

18

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9 May 2018

http://europepmc.org/abstract/MED/26657830

Ikumi Washio

19

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9 May 2018

http://europepmc.org/abstract/MED/26657830

Norimasa Miyamoto

20

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9 May 2018

http://europepmc.org/abstract/MED/26657830

publication date

4 December 2015

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9 May 2018

http://europepmc.org/abstract/MED/26657830

Journal of Pharmacological and Toxicological Methods

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78

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93-102

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Improvement of acquisition and analysis methods in multi-electrode array experiments with iPS cell-derived cardiomyocytes

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2015.12.002

7 January 2021

In vitro and in vivo models for testing arrhythmogenesis in drugs

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A highly sensitive canine telemetry model for detection of QT interval prolongation: studies with moxifloxacin, haloperidol and MK-499

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High-throughput multi-parameter profiling of electrophysiological drug effects in human embryonic stem cell derived cardiomyocytes using multi-electrode arrays.

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Human stem cell-derived cardiomyocytes detect drug-mediated changes in action potentials and ion currents.

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Comparison of electrophysiological data from human-induced pluripotent stem cell-derived cardiomyocytes to functional preclinical safety assays

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Image-based evaluation of contraction-relaxation kinetics of human-induced pluripotent stem cell-derived cardiomyocytes: Correlation and complementarity with extracellular electrophysiology.

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Cardiac safety assays

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On-chip in vitro cell-network pre-clinical cardiac toxicity using spatiotemporal human cardiomyocyte measurement on a chip

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7 January 2021

Drug-induced long QT syndrome

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MICE models: superior to the HERG model in predicting Torsade de Pointes

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7 January 2021

Cardiac safety pharmacology: from human ether-a-gogo related gene channel block towards induced pluripotent stem cell based disease models

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7 January 2021

Differentiating electrophysiological effects and cardiac safety of drugs based on the electrocardiogram: a blinded validation

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7 January 2021

The anesthetized guinea pig: an effective early cardiovascular derisking and lead optimization model

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7 January 2021

Assessment of testing methods for drug-induced repolarization delay and arrhythmias in an iPS cell-derived cardiomyocyte sheet: multi-site validation study.

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2015.12.002

7 January 2021

QT PRODACT: comparison of non-clinical studies for drug-induced delay in ventricular repolarization and their role in safety evaluation in humans

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2015.12.002

7 January 2021

The action potential and comparative pharmacology of stem cell-derived human cardiomyocytes

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7 January 2021

Human stem cell-derived cardiomyocytes in cellular impedance assays: bringing cardiotoxicity screening to the front line.

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7 January 2021

An introduction to QT interval prolongation and non-clinical approaches to assessing and reducing risk

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7 January 2021

Relationships between preclinical cardiac electrophysiology, clinical QT interval prolongation and torsade de pointes for a broad range of drugs: evidence for a provisional safety margin in drug development

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2015.12.002

7 January 2021

Key clinical considerations for demonstrating the utility of preclinical models to predict clinical drug-induced torsades de pointes

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7 January 2021

Rechanneling the cardiac proarrhythmia safety paradigm: a meeting report from the Cardiac Safety Research Consortium.

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Pharmacokinetic-pharmacodynamic modeling of QRS-prolongation by flecainide: heart rate-dependent effects during sinus rhythm in conscious telemetered dogs.

1 reference

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7 January 2021

Biological application of microelectrode arrays in drug discovery and basic research.

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2015.12.002

7 January 2021

QT PRODACT: in vivo QT assay in the conscious dog for assessing the potential for QT interval prolongation by human pharmaceuticals

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2015.12.002

7 January 2021

Pharmacokinetic/pharmacodynamic assessment of the effects of E4031, cisapride, terfenadine and terodiline on monophasic action potential duration in dog.

1 reference

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7 January 2021

A novel method of selecting human embryonic stem cell-derived cardiomyocyte clusters for assessment of potential to influence QT interval

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2015.12.002

7 January 2021

Identifiers

10.1016/J.VASCN.2015.12.002

1 reference

Europe PubMed Central

9 May 2018

http://europepmc.org/abstract/MED/26657830

1 reference

Europe PubMed Central

9 May 2018

http://europepmc.org/abstract/MED/26657830

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