Deguelins, Natural Product Modulators of NF1-Defective Astrocytoma Cell Growth Identified by High-Throughput Screening of Partially Purified Natural Product Extracts. (Q52836750)

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scientific article published on 15 October 2015

Language	Label	Description	Also known as
English	Deguelins, Natural Product Modulators of NF1-Defective Astrocytoma Cell Growth Identified by High-Throughput Screening of Partially Purified Natural Product Extracts.	scientific article published on 15 October 2015

Statements

scholarly article

1 reference

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27 February 2020

Deguelins, Natural Product Modulators of NF1-Defective Astrocytoma Cell Growth Identified by High-Throughput Screening of Partially Purified Natural Product Extracts (English)

1 reference

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27 February 2020

natural product

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inferred from title

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author name string

Curtis J Henrich

1

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27 February 2020

Laura K Cartner

2

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27 February 2020

Jennifer A Wilson

3

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27 February 2020

Richard W Fuller

4

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27 February 2020

Anthony E Rizzo

5

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27 February 2020

Karlyne M Reilly

6

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27 February 2020

James B McMahon

7

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27 February 2020

Kirk R Gustafson

8

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27 February 2020

publication date

15 October 2015

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27 February 2020

Journal of Natural Products

1 reference

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27 February 2020

78

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27 February 2020

11

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27 February 2020

2776-2781

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27 February 2020

Natural Products in High Throughput Screening: Automated High-Quality Sample Preparation

1 reference

https://pubmed.ncbi.nlm.nih.gov/26467198

12 December 2020

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Nf1;Trp53 mutant mice develop glioblastoma with evidence of strain-specific effects

1 reference

https://pubmed.ncbi.nlm.nih.gov/26467198

12 December 2020

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Modern methods to produce natural-product libraries

1 reference

https://pubmed.ncbi.nlm.nih.gov/26467198

12 December 2020

based on heuristic

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High-throughput method for the production and analysis of large natural product libraries for drug discovery

1 reference

https://pubmed.ncbi.nlm.nih.gov/26467198

12 December 2020

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Apoptosis induction by the natural product cancer chemopreventive agent deguelin is mediated through the inhibition of mitochondrial bioenergetics

1 reference

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12 December 2020

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Susceptibility to astrocytoma in mice mutant for Nf1 and Trp53 is linked to chromosome 11 and subject to epigenetic effects

1 reference

https://pubmed.ncbi.nlm.nih.gov/26467198

12 December 2020

based on heuristic

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Down-regulation of inhibitor of apoptosis proteins by deguelin selectively induces apoptosis in breast cancer cells

1 reference

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12 December 2020

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Degueline: A Rotenoid Constituent of Chadsia grevei

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https://pubmed.ncbi.nlm.nih.gov/26467198

12 December 2020

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A RELATION BETWEEN ROTENONE, DEGUELIN AND TEPHROSIN

1 reference

https://pubmed.ncbi.nlm.nih.gov/26467198

12 December 2020

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Implication of AMP-activated protein kinase and Akt-regulated survivin in lung cancer chemopreventive activities of deguelin

1 reference

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12 December 2020

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Marine natural product libraries for high-throughput screening and rapid drug discovery

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Pre-fractionated microbial samples--the second generation natural products library at Wyeth

1 reference

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12 December 2020

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Novel dual-reporter preclinical screen for antiastrocytoma agents identifies cytostatic and cytotoxic compounds

1 reference

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12 December 2020

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Evolving trends in the dereplication of natural product extracts: new methodology for rapid, small-scale investigation of natural product extracts

1 reference

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12 December 2020

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Automated high-throughput system to fractionate plant natural products for drug discovery

1 reference

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12 December 2020

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High throughput extraction of plant, marine and fungal specimens for preservation of biologically active molecules.

1 reference

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12 December 2020

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Control of proliferation in astrocytoma cells by the receptor tyrosine kinase/PI3K/AKT signaling axis and the use of PI-103 and TCN as potential anti-astrocytoma therapies

1 reference

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12 December 2020

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Natural product libraries to accelerate the high-throughput discovery of therapeutic leads

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12 December 2020

based on heuristic

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Induction of DNA damage by deguelin is mediated through reducing DNA repair genes in human non-small cell lung cancer NCI-H460 cells

1 reference

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Neoplasms associated with germline and somatic NF1 gene mutations

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The cBio cancer genomics portal: an open platform for exploring multidimensional cancer genomics data

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Deguelin, an Akt inhibitor, down-regulates NF-κB signaling and induces apoptosis in colon cancer cells and inhibits tumor growth in mice

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12 December 2020

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Deguelin, a natural rotenoid, inhibits mouse myeloma cell growth in vitro via induction of apoptosis

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12 December 2020

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Natural products: a continuing source of novel drug leads

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The molecular and cell biology of pediatric low-grade gliomas.

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Matching the power of high throughput screening to the chemical diversity of natural products

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Advances in the treatment of neurofibromatosis-associated tumours.

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Deguelin, a novel anti-tumorigenic agent targeting apoptosis, cell cycle arrest and anti-angiogenesis for cancer chemoprevention

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CBTRUS statistical report: primary brain and central nervous system tumors diagnosed in the United States in 2007-2011.

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Evaluation of a soluble tetrazolium/formazan assay for cell growth and drug sensitivity in culture using human and other tumor cell lines

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Antiviral and antitumor antibiotics. XX. Effects of rotenone, deguelin, and related compounds on animal and plant viruses

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A Simple Method for High-Throughput Extract Prefractionation for Biological Screening

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Identifiers

10.1021/ACS.JNATPROD.5B00753

1 reference

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27 February 2020

1 reference

Europe PubMed Central

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27 February 2020

1 reference

Europe PubMed Central

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27 February 2020

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