TBX3 promotes proliferation of papillary thyroid carcinoma cells through facilitating PRC2-mediated p57KIP2 repression. (Q52728409)

6 May 2018

title

TBX3 promotes proliferation of papillary thyroid carcinoma cells through facilitating PRC2-mediated p57KIP2 repression. (English)

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6 May 2018

main subject

papillary thyroid cancer

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Xiaomeng Li

1

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6 May 2018

Xianhui Ruan

2

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6 May 2018

Peitao Zhang

3

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6 May 2018

Yang Yu

4

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6 May 2018

Ming Gao

5

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6 May 2018

Shukai Yuan

6

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6 May 2018

Zewei Zhao

7

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6 May 2018

Jie Yang

8

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6 May 2018

Li Zhao

9

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6 May 2018

language of work or name

English

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publication date

7 March 2018

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6 May 2018

published in

Oncogene

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6 May 2018

https://scigraph.springernature.com/pub.10.1038/s41388-017-0090-2

exact match

0 references

cites work

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The T-Box factor TBX3 is important in S-phase and is regulated by c-Myc and cyclin A-CDK2

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The T-box repressors TBX2 and TBX3 specifically regulate the tumor suppressor gene p14ARF via a variant T-site in the initiator

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TBX3 is overexpressed in breast cancer and represses p14 ARF by interacting with histone deacetylases

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7 January 2021

TBX3, the gene mutated in ulnar-mammary syndrome, promotes growth of mammary epithelial cells via repression of p19ARF, independently of p53.

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7 January 2021

The T-box transcription factor TBX3 drives proliferation by direct repression of the p21(WAF1) cyclin-dependent kinase inhibitor

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Tbx3 represses PTEN and is over-expressed in head and neck squamous cell carcinoma

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Oncogenic B-RAF(V600E) signaling induces the T-Box3 transcriptional repressor to repress E-cadherin and enhance melanoma cell invasion

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Estrogen expands breast cancer stem-like cells through paracrine FGF/Tbx3 signaling

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Long Intergenic Noncoding RNA 00511 Acts as an Oncogene in Non-small-cell Lung Cancer by Binding to EZH2 and Suppressing p57.

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Ablation of the CDK inhibitor p57Kip2 results in increased apoptosis and delayed differentiation during mouse development.

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Altered cell differentiation and proliferation in mice lacking p57KIP2 indicates a role in Beckwith–Wiedemann syndrome

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7 January 2021

Expression of the components of the Cip/Kip family in malignant lymphoma of the thyroid.

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7 January 2021

Cell cycle regulators show diagnostic and prognostic utility for differentiated thyroid cancer.

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p57(Kip2) and cancer: time for a critical appraisal.

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Analysis of the expression of cell cycle regulators in Ewing cell lines: EWS-FLI-1 modulates p57KIP2and c-Myc expression

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7 January 2021

Identification of a Tbx1/Tbx2/Tbx3 genetic pathway governing pharyngeal and arterial pole morphogenesis

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Gene expression profiling at early organogenesis reveals both common and diverse mechanisms in foregut patterning

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Disruption of SoxB1-dependent Sonic hedgehog expression in the hypothalamus causes septo-optic dysplasia

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7 January 2021

Loss of imprinting and genetic alterations of the cyclin-dependent kinase inhibitor p57KIP2 gene in head and neck squamous cell carcinoma

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12 December 2020

Expression of p57/Kip2 protein in normal and neoplastic thyroid tissues

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12 December 2020

Aberrant methylation of p57KIP2 gene in lung and breast cancers and malignant mesotheliomas.

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12 December 2020

T-box transcription factors in cancer biology

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12 December 2020

Overexpression of Tbx3 is correlated with Epithelial-Mesenchymal Transition phenotype and predicts poor prognosis of colorectal cancer

1 reference

12 December 2020

10.1038/S41388-017-0090-2

Identifiers

DOI

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6 May 2018

PubMed ID

29511350

1 reference

6 May 2018