E-Cadherin/ROS1 Inhibitor Synthetic Lethality in Breast Cancer. (Q52722179)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29610289%20AND%20SRC:MED&resulttype=core&format=json

22 March 2020

title

E-Cadherin/ROS1 Inhibitor Synthetic Lethality in Breast Cancer (English)

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22 March 2020

10

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Stephen J Pettitt

15

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Elinor J. Sawyer

21

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22 March 2020

Spiros Linardopoulos

24

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Rachael Natrajan

25

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Colm J. Ryan

26

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Christopher J Lord

31

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12

James Campbell

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22 March 2020

author name string

Ilirjana Bajrami

1

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Rebecca Marlow

2

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22 March 2020

Marieke van de Ven

3

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Rachel Brough

4

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22 March 2020

Helen N Pemberton

5

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Jessica Frankum

6

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Feifei Song

7

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Rumana Rafiq

8

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Asha Konde

9

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Malini Menon

11

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Aditi Gulati

13

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22 March 2020

Rahul Kumar

14

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22 March 2020

Mark D Gurden

16

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Marta Llorca Cardenosa

17

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Irene Chong

18

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Patrycja Gazinska

19

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Fredrik Wallberg

20

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22 March 2020

Lesley-Ann Martin

22

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22 March 2020

Patrick W B Derksen

27

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22 March 2020

Jos Jonkers

28

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Andrew N J Tutt

29

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Mitch Dowsett

23

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Alan Ashworth

30

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publication date

1 April 2018

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22 March 2020

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volume

8

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22 March 2020

issue

4

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22 March 2020

page(s)

498-515

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Regulation of E-cadherin/Catenin association by tyrosine phosphorylation.

22 March 2020

cites work

1 reference

12 December 2020

Tyrosine phosphorylation of p120(ctn) in v-Src transfected L cells depends on its association with E-cadherin and reduces adhesion activity

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12 December 2020

Molecular changes associated with the acquisition of oestrogen hypersensitivity in MCF-7 breast cancer cells on long-term oestrogen deprivation

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12 December 2020

Invasive lobular carcinoma classic type: response to primary chemotherapy and survival outcomes

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12 December 2020

Somatic inactivation of E-cadherin and p53 in mice leads to metastatic lobular mammary carcinoma through induction of anoikis resistance and angiogenesis.

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12 December 2020

Selective induction of chemotherapy resistance of mammary tumors in a conditional mouse model for hereditary breast cancer

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12 December 2020

The regulatory or phosphorylation domain of p120 catenin controls E-cadherin dynamics at the plasma membrane

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12 December 2020

Enhancing endocrine response with novel targeted therapies: why have the clinical trials to date failed to deliver on the preclinical promise?

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12 December 2020

Loss of p120 catenin and links to mitotic alterations, inflammation, and skin cancer

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12 December 2020

Cadherins and cancer: how does cadherin dysfunction promote tumor progression?

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12 December 2020

Distinct gene mutation profiles among luminal-type and basal-type breast cancer cell lines

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12 December 2020

Significance of E-cadherin expression in triple-negative breast cancer

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12 December 2020

Mammary-specific inactivation of E-cadherin and p53 impairs functional gland development and leads to pleomorphic invasive lobular carcinoma in mice

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12 December 2020

Chelerythrine perturbs lamellar actomyosin filaments by selective inhibition of myotonic dystrophy kinase-related Cdc42-binding kinase

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12 December 2020

Genetic Interactions in Cancer Progression and Treatment

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12 December 2020

ChimeraScan: a tool for identifying chimeric transcription in sequencing data

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12 December 2020

Functional viability profiles of breast cancer

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12 December 2020

Mechanism of action of the multikinase inhibitor Foretinib.

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12 December 2020

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity

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12 December 2020

Synthetic lethality of PARP and NAMPT inhibition in triple-negative breast cancer cells

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12 December 2020

Invasive lobular carcinoma of the breast: patient response to systemic endocrine therapy and hormone response in model systems

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12 December 2020

Loss of E-cadherin is not a necessity for epithelial to mesenchymal transition in human breast cancer.

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12 December 2020

Adhesion disengagement uncouples intrinsic and extrinsic forces to drive cytokinesis in epithelial tissues

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Acquired Resistance to Crizotinib from a Mutation in CD74 – ROS1

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A renewable tissue resource of phenotypically stable, biologically and ethnically diverse, patient-derived human breast cancer xenograft models

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Foretinib is a potent inhibitor of oncogenic ROS1 fusion proteins.

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12 December 2020

Invasive lobular carcinoma cell lines are characterized by unique estrogen-mediated gene expression patterns and altered tamoxifen response

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12 December 2020

HER2, MET and FGFR2 oncogenic driver alterations define distinct molecular segments for targeted therapies in gastric carcinoma

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12 December 2020

E-cadherin loss alters cytoskeletal organization and adhesion in non-malignant breast cells but is insufficient to induce an epithelial-mesenchymal transition

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12 December 2020

A novel small-molecule MRCK inhibitor blocks cancer cell invasion

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12 December 2020

A comprehensive transcriptional portrait of human cancer cell lines

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12 December 2020

PF-06463922 is a potent and selective next-generation ROS1/ALK inhibitor capable of blocking crizotinib-resistant ROS1 mutations

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12 December 2020

Lobular breast cancer: molecular basis, mouse and cellular models

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12 December 2020

The proteomic landscape of triple-negative breast cancer

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12 December 2020

E-cadherin junctions as active mechanical integrators in tissue dynamics

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12 December 2020

Myotonic dystrophy kinase-related Cdc42-binding kinases (MRCK), the ROCK-like effectors of Cdc42 and Rac1.

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12 December 2020

Relative Effectiveness of Letrozole Compared With Tamoxifen for Patients With Lobular Carcinoma in the BIG 1-98 Trial

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12 December 2020

Crizotinib-induced antitumour activity in human alveolar rhabdomyosarcoma cells is not solely dependent on ALK and MET inhibition

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12 December 2020

Comprehensive Molecular Portraits of Invasive Lobular Breast Cancer

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12 December 2020

Integration of genomic, transcriptomic and proteomic data identifies two biologically distinct subtypes of invasive lobular breast cancer

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12 December 2020

Genomic Characterization of Primary Invasive Lobular Breast Cancer

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12 December 2020

Large-Scale Profiling of Kinase Dependencies in Cancer Cell Lines

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Characterizing genomic alterations in cancer by complementary functional associations

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Enrichr: a comprehensive gene set enrichment analysis web server 2016 update

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12 December 2020

Lobular breast cancer: Clinical, molecular and morphological characteristics

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12 December 2020

Synthetic Lethal Targeting of ARID1A-Mutant Ovarian Clear Cell Tumors with Dasatinib

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12 December 2020

A Biobank of Breast Cancer Explants with Preserved Intra-tumor Heterogeneity to Screen Anticancer Compounds

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12 December 2020

Prognostic Value of E-Cadherin and β-Catenin in Triple-Negative Breast Cancer.

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12 December 2020

p120-catenin prevents multinucleation through control of MKLP1-dependent RhoA activity during cytokinesis

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12 December 2020

A Compendium of Co-regulated Protein Complexes in Breast Cancer Reveals Collateral Loss Events.

1 reference

12 December 2020

10.1158/2159-8290.CD-17-0603

Identifiers

DOI

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22 March 2020

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22 March 2020

PubMed publication ID

29610289

1 reference