Increased neutrophil extracellular trap formation promotes thrombosis in myeloproliferative neoplasms. (Q52719979)

http://europepmc.org/abstract/MED/29643232

6 May 2018

title

Increased neutrophil extracellular trap formation promotes thrombosis in myeloproliferative neoplasms (English)

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Ofir Wolach

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Rob S Sellar

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Kimberly Martinod

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Marie McConkey

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Alexander J Silver

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Robert F Padera

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Ilene Galinsky

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Giulio Genovese

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Denisa D Wagner

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Benjamin L. Ebert

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author name string

Deya Cherpokova

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Ryan J Chappell

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Dylan Adams

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Cecilia A Castellano

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Rebekka K Schneider

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Daniel J DeAngelo

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Martha Wadleigh

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Richard M Stone

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Steven A McCarroll

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Bozenna Iliadou

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Ann Mullally

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13 May 2020

language of work or name

English

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publication date

1 April 2018

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http://europepmc.org/abstract/MED/29643232

6 May 2018

published in

Science Translational Medicine

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volume

10

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issue

436

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describes a project that uses

13 May 2020

ImageJ

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC6442466/fullTextXML

inferred from PubMed Central ID database lookup

cites work

Life-threatening thrombotic and haemorrhagic problems associated with silent myeloproliferative disorders

1 reference

12 December 2020

Neutrophil extracellular traps kill bacteria

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12 December 2020

Expression of Jak2V617F causes a polycythemia vera-like disease with associated myelofibrosis in a murine bone marrow transplant model

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12 December 2020

Leukocytosis as a major thrombotic risk factor in patients with polycythemia vera

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12 December 2020

Leukocytosis and Risk Stratification Assessment in Essential Thrombocythemia

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12 December 2020

Histone hypercitrullination mediates chromatin decondensation and neutrophil extracellular trap formation.

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12 December 2020

Thrombosis in primary myelofibrosis: incidence and risk factors

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12 December 2020

Preclinical characterization of the selective JAK1/2 inhibitor INCB018424: therapeutic implications for the treatment of myeloproliferative neoplasms

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12 December 2020

Physiological Jak2V617F expression causes a lethal myeloproliferative neoplasm with differential effects on hematopoietic stem and progenitor cells

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12 December 2020

PAD4 is essential for antibacterial innate immunity mediated by neutrophil extracellular traps

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12 December 2020

Extracellular DNA traps promote thrombosis.

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12 December 2020

Neutrophil extracellular traps promote deep vein thrombosis in mice

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12 December 2020

A double-blind, placebo-controlled trial of ruxolitinib for myelofibrosis

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12 December 2020

Leukocytosis as an important risk factor for arterial thrombosis in WHO-defined early/prefibrotic myelofibrosis: an international study of 264 patients.

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12 December 2020

Correlation of blood counts with vascular complications in essential thrombocythemia: analysis of the prospective PT1 cohort

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12 December 2020

Cancers predispose neutrophils to release extracellular DNA traps that contribute to cancer-associated thrombosis

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12 December 2020

PAD4 mediated histone hypercitrullination induces heterochromatin decondensation and chromatin unfolding to form neutrophil extracellular trap-like structures

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12 December 2020

Extracellular DNA traps in allergic, infectious, and autoimmune diseases

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JAK2 mutation-related disease and thrombosis

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Neutrophil histone modification by peptidylarginine deiminase 4 is critical for deep vein thrombosis in mice.

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Myeloproliferative neoplasms and thrombosis.

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12 December 2020

Increased reactive oxygen species production and p47phox phosphorylation in neutrophils from myeloproliferative disorders patients with JAK2 (V617F) mutation

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12 December 2020

Somatic mutations of calreticulin in myeloproliferative neoplasms

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12 December 2020

Thrombosis: tangled up in NETs

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Induction and quantification of neutrophil extracellular traps

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Thrombosis in myeloproliferative neoplasms

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12 December 2020

Integrated genomic analysis illustrates the central role of JAK-STAT pathway activation in myeloproliferative neoplasm pathogenesis

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Hemostatic disorders in a JAK2V617F-driven mouse model of myeloproliferative neoplasm

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Clonal hematopoiesis and blood-cancer risk inferred from blood DNA sequence

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Inhibition of PAD4 activity is sufficient to disrupt mouse and human NET formation.

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Ruxolitinib versus standard therapy for the treatment of polycythemia vera.

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Diabetes primes neutrophils to undergo NETosis, which impairs wound healing

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White blood cell counts and thrombosis in polycythemia vera: a subanalysis of the CYTO-PV study.

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Intact Toll-like receptor 9 signaling in neutrophils modulates normal thrombogenesis in mice

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12 December 2020

At the Bedside: Neutrophil extracellular traps (NETs) as targets for biomarkers and therapies in autoimmune diseases.

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12 December 2020

Neutrophil elastase-deficient mice form neutrophil extracellular traps in an experimental model of deep vein thrombosis

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Persistent neutrophilia is a marker for an increased risk of venous thrombosis.

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In Vivo Role of Neutrophil Extracellular Traps in Antiphospholipid Antibody-Mediated Venous Thrombosis

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12 December 2020

Neutrophil extracellular trap formation and circulating nucleosomes in patients with chronic myeloproliferative neoplasms

1 reference

12 December 2020

10.1126/SCITRANSLMED.AAN8292

Identifiers

DOI

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6442466&resulttype=core&format=json

13 May 2020

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13 May 2020

1 reference