Functional Anti-TIGIT Antibodies Regulate Development of Autoimmunity and Antitumor Immunity. (Q52676482)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29500245%20AND%20SRC:MED&resulttype=core&format=json

19 March 2020

title

Functional Anti-TIGIT Antibodies Regulate Development of Autoimmunity and Antitumor Immunity (English)

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19 March 2020

1

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19 March 2020

Michelle Schorer

2

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19 March 2020

James Nevin

3

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19 March 2020

Raymond A Sobel

9

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19 March 2020

Rakesh Jain

11

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Nicole Joller

14

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13

Vijay K Kuchroo

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19 March 2020

10

Dai Fukumura

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19 March 2020

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Zohreh Amoozgar

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19 March 2020

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Yassaman Etminan

4

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19 March 2020

Takaaki Kondo

6

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19 March 2020

Sema Kurtulus

7

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19 March 2020

Nasim Kassam

8

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19 March 2020

Ana C Anderson

12

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language of work or name

English

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publication date

2 March 2018

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19 March 2020

published in

Journal of Immunology

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19 March 2020

volume

200

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19 March 2020

page(s)

3000-3007

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19 March 2020

issue

8

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Targeting T Cell Co-receptors for Cancer Therapy

19 March 2020

cites work

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5893394

Lag-3, Tim-3, and TIGIT: Co-inhibitory Receptors with Specialized Functions in Immune Regulation.

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5893394

Ang-2/VEGF bispecific antibody reprograms macrophages and resident microglia to anti-tumor phenotype and prolongs glioblastoma survival

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5893394

TIGIT predominantly regulates the immune response via regulatory T cells.

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5893394

T-cell exhaustion, co-stimulation and clinical outcome in autoimmunity and infection.

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5893394

TIGIT and PD-1 impair tumor antigen-specific CD8⁺ T cells in melanoma patients

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5893394

The immunoreceptor TIGIT regulates antitumor and antiviral CD8(+) T cell effector function

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5893394

Treg cells expressing the coinhibitory molecule TIGIT selectively inhibit proinflammatory Th1 and Th17 cell responses

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5893394

The TIGIT/CD226 axis regulates human T cell function

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5893394

Vstm3 is a member of the CD28 family and an important modulator of T-cell function

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5893394

Cutting edge: TIGIT has T cell-intrinsic inhibitory functions

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5893394

Non-synonymous variant (Gly307Ser) in CD226 is associated with susceptibility to multiple autoimmune diseases

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5893394

The interaction of TIGIT with PVR and PVRL2 inhibits human NK cell cytotoxicity

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5893394

The surface protein TIGIT suppresses T cell activation by promoting the generation of mature immunoregulatory dendritic cells

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5893394

CD226 Gly307Ser association with multiple autoimmune diseases

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5893394

Myelin-specific regulatory T cells accumulate in the CNS but fail to control autoimmune inflammation.

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5893394

Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5893394

2 November 2018

Identifiers

DOI

10.4049/JIMMUNOL.1700407

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29500245%20AND%20SRC:MED&resulttype=core&format=json

19 March 2020

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29500245%20AND%20SRC:MED&resulttype=core&format=json

19 March 2020

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